Designing High-Pressure Capable, Corrosion-Resistant Columns for Cation-Exchange Chromatography

Library Number:
APNT135012584
Part Number:
720006051EN
Author(s):
Waters
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:
 
 

The goal of this study is to mitigate frit and column hardware corrosion, and prevent metal cation poisoning with BioResolve™ SCX mAb Columns.

The frit and column hardware used in the BioResolve SCX mAb Column as well as the VanGuard™ FIT (Fully Integrated Technology) option have been purposely designed to mitigate corrosion, while maintaining packed column performance. Both construction materials and design implementation were considered to accomplish this goal. Most notably, titanium is used along with polymeric seals in strategic locations to afford excellent performance despite regular exposure to corrosive conditions.


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