Controlling Analytical Method Variability with Key Approaches to Sample Handling and Preparation

Sample handling and preparation can have a substantial effect on an analytical method’s variability and data quality.  It is important to consider and address the risks associated with sample preparation as part of the method development process.  This requires carefully designed and executed experiments and clear documentation in the method to give the analyst an…

Visions of the Technological Future

As technology evolves at an ever-increasing rate, the future draws nearer. An 11-year-old today is expected to see a 64-fold increase in computing power by the time they finish high school.[1] From global internet connectivity to smart phones, the incredible innovations from the last few decades have become building blocks to transform life as we…

Sustainable Solutions for Plastics: The Future Role of Lignins

Plastics – Friend and Foe If you’re like me, you’ve probably seen images of all the floating plastic in the Great Pacific garbage patch or perhaps you’ve seen the images of wildlife rescuers trying to remove a plastic straw from a sea turtle’s nose. These images can be quite disturbing and destructive to the reputation…

The University of Neuchâtel Selects the SYNAPT™ XS to Enable Future Discoveries in Plant Metabolomics

After a comprehensive evaluation process, The University of Neuchâtel in Switzerland recently made the decision to add the newly released SYNAPT XS to their mass spectrometry instrument portfolio. Dr. Gaétan Glauser, a senior scientist at the Neuchâtel Platform of Analytical Chemistry (NPAC) facility, has core specialisms in plant analytical chemistry and metabolomics. Dr. Glauser and…

Sample Profiling of Pesticide Formulations Using UV and MS Detection for Component Identification

For the agricultural chemicals industry, the analytical quality control of pesticide products ensures that a consistent and effective product reaches the farm. More specifically, the detection, characterization, and quantitation of the active ingredient(s) as well as all other components in the formulation, including impurities and degradation products, are necessary to support product development, quality control,…

Nitrosamine Impurities: The Need to Verify

The recent nitrosamine impurity crisis has brought into question the quality of many APIs (Active Pharmaceutical Ingredients) produced and sourced for a number of popular drugs, resulting in product recalls, lost profits, and regulatory actions. Within a drug manufacturing process that is increasingly outsourced and globalized, companies manufacturing the API or in-sourcing the API or…

Waters Opens New Swedish Head Office and Open Access Laboratory

On October 2, 2019, Waters proudly opened our new Swedish head office and laboratory in the House of Innovations, located in the center of Campus Solna next to Karolinska Institutet. The new facility features an open access laboratory designed to provide students, scientists and startup companies with an experienced technical staff and easy-to-use automation infrastructure…

IonHance

Mobile Phase Additives for Peptide Characterization

The characterization of peptides and proteins can be challenging due to issues such as adsorption, varying hydrophobicities, and specificity to name just a few. When analyzing peptides by Liquid Chromatography (LC) and Mass Spectrometry (MS), it’s beneficial to introduce mobile phase additives in order to facilitate ionization and enhance the analyte signal. Additionally, these additives…

Supporting the Next Generation of STEM Professionals

As a science-based organization, STEM education is of the utmost importance to Waters. This blog highlights the excitement of its partnership with Junior Achievement, one of the world’s largest youth-serving NGOs that prepares young people for employment and entrepreneurship.

Why does biomedical research matter?

Summer break is coming to a close and the thought of fall quickly approaching hangs heavy in the air. The mornings are cool and pleasant, perfect for sleeping. And, here I am, sipping coffee at 5:30AM. Why is it that on mornings like this, when most of the world is asleep, so many biomedical researchers are…

Amgen, UCLA, and University of Arizona Use BioResolve RP mAb Polyphenyl Columns for Rapid LC-MS Screening of Membrane Proteins

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As a chromatography scientist at Waters, I often get the opportunity to travel to different laboratories around the world and to meet with various types of researchers. This allows me to stay up to date on the newest scientific trends and topics, particularly in the fast growing world of biopharmaceutical analysis. In June of this…

ACQUITY UPLC – 15 Years On and Still Going Strong

The 30th James L. Waters Annual Symposium  will take place on Monday, March 18 in Philadelphia as part of Pittcon 2019. The theme of this year’s Symposium focuses on early research efforts required to develop Ultra High Pressure Liquid Chromatography (UHPLC) and the impact that the adoption of this technology had on the analytical chemistry…