Tandem Quad Mass Spectrometry: The Foundation of Product Safety, Efficacy, and Decision-making

There is a rightfully high expectation from consumers that the amounts of compounds and ingredients that producers report in their goods are accurate down to trace levels.  Whether personally or professionally, we all rely on this analytical information coming from laboratories that enables critical decisions to be made. Analytical chemists have been performing quantitative studies…

WRIB 2016: Diversity of Platforms and Approaches Needed for Bioanalysts

Held April 18–22 in Lake Buena Vista, Florida, WRIB 2016 was well attended this year, with about 700 attendees. This 10th Workshop on Recent Issues in Bioanalysis, where regulators and professionals representing pharma/biopharma, biotech, CRO organizations gather to discuss challenges in method development and emerging approaches, proved as fruitful as years past. Here are a…

Simon Fraser University Opens Suite of Mass Spectrometers for Natural Products Discovery Research

As a graduate student at the University of British Columbia, Dr. Roger Linington discovered his future life’s work serendipitously. While studying sponges, it became clear to him that one of the challenges in studying macroorganisms is their limited or slowly replenishing supply. To perform mechanism and mode-of-action studies, he needed a larger, more accessible source…

Molecular Visualization: Mass Spec Imaging Delivers Insights for Cancer Research

How does mass spectrometry (MS) imaging provide a molecular image that can be used for the biochemical characterization of histological images? A rapidly developing technique for clinical research, MS imaging enables investigation of the spatial distribution of molecules at complex surfaces. It’s a direct-from-sample analytical technique that provides researchers with the information needed to quickly…

Metabolic Blurred Lines: Is Biotransformation the next Met ID?

  You are the hunter in a landscape of scientific gatherers, the stealthy SEAL of DMPK, the nimble ninja of ADME. You are a Metabolite ID scientist. Traditionally, Met ID labs have been a fixture of any pharmaceutical company worth its salt. Now, imagine that your proud band of comrades has been phased out, split…

Can Sports Cars Increase Testosterone?

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According to published reports by Hiscox UK in 2008,  just listening to the sound of a sports car increased salivary testosterone levels in male and female participants. Another study, by Gad Saad et al, measured a testosterone increase in men who were given the opportunity to drive a $150,000 Porsche 911 Carrera Cabriolet for an…

What do an ancient Chinese Ruler and Waters’ Mass Spectrometry Research Team have in common?

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Tea is very important to them! If Waters Wilmslow ran out of tea it is likely the MS Research Team would struggle to function. The ancient Chinese Ruler, Emperor Jing Di, took tea to the grave with him for a cuppa in the afterlife. Many treasures were found in his tomb including; food, weapons, ceramic animals,…

5 Insights: Protein Quantification Using the Surrogate Peptide Method

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What can you get all the top Pharma and CRO’s scientists to agree on? That the biopharma industry is growing and quantifying biotherapeutics for bioanalysis is difficult – but you have options.

Is Ion Mobility Mass Spectrometry Child’s Play?

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On Wednesday evening after dinner and my usual digestif, I was watching the webcast “Making Ion Mobility Mass Spectrometry Routine” when my son walked by. “Wow dad, that’s kind of cool! What the heck is it?” he asked. “It’s ion mobility!! It’s an orthogonal and complementary resource for chromatography and mass spectrometry…” The digestif was…

Which LC Detector Should I Buy?

You might not like the answer… So the other day, I was with a customer when they asked me, “Viet, there are so many detectors out there! How do I know which one I need?”  To which I answered with the one comment that all of you will love to hate, “It depends!” Detectors for…

Analytical Chemists Are Going Extinct?

Endangered analytical chemists face myriad obstacles today – lower than average job forecasts 1, costly and timely training, demand for more versatile knowledge, tighter regulations, and massive data management requirements. Perhaps most significantly, mass spectrometry market forecasts predict a lack of skilled users as a key market constraint2. Senior analytical chemists are presented with a…

Multiple Attribute Monitoring of Biopharmaceuticals Using Mass Detection

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Multiple attribute monitoring has become a hot topic of discussion within biopharmaceutical organizations as the methodology allows detection and measurement of more critical quality attributes than conventional methods. Waters recently sponsored an outstanding webinar on this topic, hosted by Genetic Engineering News and presented by our own Biopharmaceutical Senior Manager, Sean M. McCarthy, Ph.D. Watch…