Benefits of Partnering with Organizations on System Evaluation
For contract organizations working in the pharmaceutical industry, operating at peak performance and capacity is a vital step towards delivering life-saving therapies.
Bringing it all together – A modern solution for oligonucleotide analysis
Solving analytical challenges is at the core of our DNA and when it comes to oligonucleotide analysis, we’re at a point now where we can bring together the many advancements we’ve made across the analytical value stream into complete end-to-end workflows that truly deliver best-in-class analytical performance and productivity.
Automating Intact Mass Deconvolution: It’s About Time
Waters has been progressing intact mass analyses for an equally long time. Development of the new waters_connect INTACT Mass app was a user-centric process.
![Attribute Monitoring Workflows [Infographic]](https://www.waters.com/blog/wp-content/uploads/feature-image-768x758.png.webp)
Attribute Monitoring Workflows [Infographic]
Learn how the BioAccord LC-MS System is instrumental in the drug development workflow from sample prep to reporting.
BioAccord System with ACQUITY Premier: Some Things Work Better Together
Combining BioAccord, our most capable MS detection platform, with ACQUITY Premier UPLC, our highest performance LC system, to demonstrate superior performance.
Biopharma’s Future: Next-Generation LC-MS Workflows for Peptide MAM
The development of biotherapeutics continues to accelerate with their potential to revolutionize disease treatment in areas not adequately addressed by small molecule therapeutics. However, the complexity of these macromolecules and the range of potential modification variants (attributes) creates an interesting analytical challenge for scientists tasked with their characterization and then with monitoring those attributes important…
5 Peptide Bioanalysis Sample Preparation Challenges (and how to overcome them!)
Scientists that have worked with peptides understand that peptide quantification can be challenging. One of the keys to successful peptide analysis is thorough and selective sample preparation. Sample preparation improves various aspects of chromatography and mass spectrometry analyses by utilizing solid phase extraction (SPE) to chemically separate different analytes and aid in removing the interfering…
Mobile Phase Additives for Peptide Characterization
The characterization of peptides and proteins can be challenging due to issues such as adsorption, varying hydrophobicities, and specificity to name just a few. When analyzing peptides by Liquid Chromatography (LC) and Mass Spectrometry (MS), it’s beneficial to introduce mobile phase additives in order to facilitate ionization and enhance the analyte signal. Additionally, these additives…
Sample Prep before LC-MS Quantification of Peptides and Proteins
Confronting the challenge of sensitivity and sample loss As a relative newcomer to peptide and protein quantification coming from the small molecule world, I have learned that I need to think differently, and more creatively, to meet the challenges of these molecules. As scientists with assay sensitivity goals, we sometimes have to take extra steps…
Lost Samples in the Container: Non-specific Binding and the Impact of Blocking Agents
My sample stayed in the solution…or did it? Samples are precious. Well-prepared samples are the starting point of all successful experiments. That’s why we spend time and effort on sample preparation; so that the resulting samples are ready for downstream LC analyses. When we think of good sample prep and handling, we emphasize the sample…
Amgen, UCLA, and University of Arizona Use BioResolve RP mAb Polyphenyl Columns for Rapid LC-MS Screening of Membrane Proteins
As a chromatography scientist at Waters, I often get the opportunity to travel to different laboratories around the world and to meet with various types of researchers. This allows me to stay up to date on the newest scientific trends and topics, particularly in the fast growing world of biopharmaceutical analysis. In June of this…
Where Did My Sample Go?
Non-specific binding of protein and peptides continues to plague scientists with low recovery. high variability, and poor sensitivity. Are you doing enough to combat non-specific binding?