A bowl of nuts, with polished or carved nutcrackers, is part of many traditional winter holiday feasts. Growing up in England in the 1970s, I enjoyed hazelnuts, almonds, walnuts and Brazil nuts as special treats for the Christmas holiday. Once I’d wrestled with a nutcracker, seemingly designed to send nuts and shards of shell across…
The use of light during holidays or festivals – in any form, including candles, lanterns, or fireworks – is significant, as we celebrate and look ahead to the future. Many friends and colleagues recently celebrated Diwali (where light represents the triumph of good over evil and light over darkness), and others begin Hanukkah, the Festival…
A Breakthrough in Dioxin Analysis for Environmental Laboratories In September, the United States Environmental Protection Agency (USEPA) recognized the use of atmospheric pressure gas chromatography (APGC) with tandem quadrupole mass spectrometry (MS) as an acceptable alternative to traditional high-resolution magnetic sector mass spectrometry for USEPA Method 1613. The recognition frees laboratories to adopt the Waters…
From fundamental research to routine analysis, Waters’ latest innovations in mass spectrometry enable our customers to gain – and apply – insights across the scientific spectrum. Beginning with fundamental research where the focus is on unraveling molecular complexity, new enhancements to the SELECT SERIES™ Cyclic IMS now support a combination of fragmentation and imaging strategies…
Digging deep into the human biome, Professor Yoshiya Oda of the Graduate School of Medicine at the University of Tokyo looks to ion mobility technology to uncover deposits of insight It’s an established fact that the more people age, the more they tend to engage with health care providers than they did when they were…
The characterization of peptides and proteins can be challenging due to issues such as adsorption, varying hydrophobicities, and specificity to name just a few. When analyzing peptides by Liquid Chromatography (LC) and Mass Spectrometry (MS), it’s beneficial to introduce mobile phase additives in order to facilitate ionization and enhance the analyte signal. Additionally, these additives…
What does “intelligence” mean in the context of biopharma analysis? Given the complex setting, much of the answer comes down to the task a user needs to complete, along with the question of who exactly that user is. In developing our BioAccord System, we wanted to expand the possibilities of high-resolution LC-MS analysis from characterization…
There are two primary multi-attribute monitoring (MAM) assay choices for biologic development and QC: subunit protein mass analysis and peptide mapping by LC-MS. Here we explore how peptide mapping LC-MS MAM workflows are being used.
Two MAM approaches for biotherapeutic analysis are being implemented today; one focused on the analysis of monoclonal antibody (mAb) subunits, and the other focused on the analysis of peptides from a protein digest (peptide mapping workflow). Both have their advantages and disadvantages. Here, we explore MAM for mAb subunit analysis.
Q&A time: What is acrylamide? How dangerous is it? How do food testing laboratories detect it?
The improvements in LC-MS technology under GxP compliant-ready informatics for biopharmaceutical analysis has prepared the industry to expand the role of MS technologies beyond product characterization toward monitoring product and process quality attributes.
Where does your service engineer turn if they need help? Meet Dipesh. He works in Waters’ Global Service Support (GSS) department in Wilmslow, UK. The team supports field service engineers, writes supporting documentation, and advises on service requirements for new products.