• Application Note

Pseudoephedrine HCL and Triprolidine HCL

Pseudoephedrine HCL and Triprolidine HCL
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief highlights the analysis of Pseudoephedrine HCL and Triprolidine HCL using Symmetry Columns. 

Introduction

The compounds analyzed in this study are:

  1. Pseudoephedrine HCL 
  2. Triprolidine HCL 

Experimental

HPLC Method

Column:

Symmetry C8, 3.9 x 150 mm, 5 μm

Guard column:

Symmetry Guard Column 3.9 x 20 mm, 5 μm

Part numbers:

Column - WAT046970, Guard - WAT054250

Mobile phase A:

50 mM potassium phosphate, pH 3.0

Mobile phase B:

Acetonitrile

Flow rate:

1.0 mL/min

Injection volume:

5 μL of 2.88 μg/mL pseudoephedrine and 120 μg/mL triprolidine extracted tablet sample

Detection:

UV @ 261 nm

Gradient Table

USP Tailing Factors

  1. 1.53 
  2. 1.16 

Results and Discussion

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WA31763.138, June 2003

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