样品前处理

开发并验证一种简单、高选择性、高灵敏度的LC-MS/MS分析方法，用于定量分析人血浆中的瑞德西韦(Development and validation of a simple, selective, and sensitive LC-MS/MS assay for the quantification of remdesivir in human plasma)
— Ryan Nguyen; Jennifer C. Goodell; Priya S.Shankarappa; Sara Zimmerman; Tyler Yin; Cody J. Peer; William D. Figg.Journal of Chromatography B.
DOI: 10.1016/j.jchromb.2021.122641.

使用一站式样品前处理程序，通过LC–MS/MS同时测定人血浆中的氟西汀(fluoxetine)、文拉法辛(venlafaxine)、沃替西汀(vortioxetine)及其活性代谢物(Simultaneous determination of fluoxetine, venlafaxine, vortioxetine and their active metabolites in human plasma by LC–MS/MS using one-step sample preparation procedure)
— Martin Kertys; Michaela Krivosova; Igor Ondrejka; Igor Hrtanek; Ingrid Tonhajzerova. Journal of Pharmaceutical and Biomedical Analysis.
DOI: 10.1016/j.jpba.2020.113098.

慢性肾病大鼠体内通过磷脂酶A2评估磷脂酰胆碱的整体代谢(Integrative phosphatidylcholine metabolism through phospholipase A2 in rats with chronic kidney disease)
— Yan-ni Wang; Zhi-hao Zhang; Hong-jiao Liu; Zhi-yuan Guo; Liang Zou; Ya-mei Zhang; Ying-yong Zhao. Acta Pharmacologica Sinica, 44, 393–405 (2023).

脐带血浆中血浆全氟烷基和多氟烷基化合物(PFAS)与新生儿及儿童身体组成和脂肪分布的关联研究：GUSTO研究(Associations of Cord Plasma Per- and Polyfluoroalkyl Substances (PFAS) with Neonatal and Child Body Composition and Adiposity: The GUSTO Study)
— Chen, L.-W.; Ng, S.; Tint, M.-T.; Michael, N.; Sadananthan, S. A.; Ong, Y. Y.; Yuan, W. L.; Chen, Z.-Y.; Chen, C.-Y.; Godfrey, K. M.; Tan, K. H.; Gluckman, P. D.; Chong, Y.-S.; Eriksson, J. G.; Yap, F.; Lee, Y. S.; Fortier, M. V.; Velan, S. S.; Chan. Environ. Int. 2024.
DOI: 10.1016/j.envint.2024.112936.

利用超高效超临界流体色谱-串联质谱法定量测定人血清中的R/S-美沙酮：一种常规使用方法(Quantitative Determination of R/S-Methadone in Human Serum Using Ultra-High Performance Supercritical Fluid Chromatography-Tandem Mass Spectrometry: A Method for Routine Use)
— Hansen, M.; Havnen, H.; Andreassen, T. N.; Spigset, O.; Hegstad, S. Drug Test.Anal. 2024.
DOI: 10.1002/dta.3693

通过同时进行组织笼和超滤液收集证明，在药代动力学研究中，莫西菌素是一种用作体内内标的候选物(Moxidectin is a candidate for use as an in vivo internal standard in pharmacokinetic studies, as demonstrated with use in simultaneous tissue cage and ultrafiltration fluid collection)
— Munn, R.; Whittem, T. Front.Vet.Sci. 2024, 11.
DOI: 10.3389/fvets.2024.1332974.

使用能够释放一氧化氮的PDE5抑制剂配方进行小鼠的局部伤口处理，可增强血液灌注并促进愈合(Topical Wound Treatment with a Nitric Oxide-Releasing PDE5 Inhibitor Formulation Enhances Blood Perfusion and Promotes Healing in Mice)
— Maya Ben-Yehuda Greenwald; Yu-Hang Liu; Weiye Li;Paul Hiebert; Maria Zubair; Hermann Tenor; Tobias Braun; Reto Naef; Daniel Razansky; Sabine Werner. Pharmaceutics 2022, 14(11), 2358.
DOI: 10.3390/pharmaceutics14112358.

人类暴露组研究中，质谱分析的样品前处理策略：现状与未来展望(Sample preparation strategies for mass spectrometry analysis in human exposome research: Current status and future perspectives)
— Yunyun Gu; Jesse T. Peach; Benedikt Warth. TrAC Trends in Analytical Chemistry.
DOI: 10.1016/j.trac.2023.117151.

替比培南的药效动力学：口服治疗多重耐药性革兰氏阴性菌感染的新选择(Pharmacodynamics of Tebipenem: New Options for Oral Treatment of Multidrug-Resistant Gram-Negative Infections)
— Laura McEntee; Adam Johnson; Nicola Farrington; Jennifer Unsworth; Aaron Dane; Akash Jain; Nicole Cotroneo; Ian Critchley; David Melnick; Thomas Parr; Paul G. Ambrose; Shampa Das; William Hope. ASM Journals.
DOI: 10.1128/aac.00603-19.

不同繁殖状态（妊娠和哺乳期）野生雌兔(Oryctolagus cuniculus)的靶向和非靶向代谢组学分析(Targeted and untargeted metabolomic profiles in wild rabbit does (Oryctolagus cuniculus) of different breeding states (pregnant and lactating))
— Marín-García, P. J.; Rouco, C.; Llobat, L.; Larsen, T.; Hedemann, M. S. J. Exp.Zool.A 2024.
DOI: 10.1002/jez.2818

ICA-1S长期暴露的临床前试验：一种有效的蛋白激酶C-ι抑制剂，可作为潜在的上皮癌治疗药物(Preclinical Testing of Chronic ICA-1S Exposure: A Potent Protein Kinase C-ι Inhibitor as a Potential Carcinoma Therapeutic)
— Apostolatos, C. A.; Ratnayake, W. S.; Breedy, S.; Chuah, J. K. C.; Miller, J. A.; Zink, D.; Bourgeois, M.; Acevedo-Duncan, M. Drugs Drug Candidates 2024, 3(2), 368–379.
DOI: 10.3390/ddc3020022.

角化细胞中的葡萄糖代谢重编程在银屑病与代谢综合征之间的关联中所发挥的作用(Role of Glucose Metabolism Reprogramming in Keratinocytes in the Link between Psoriasis and Metabolic Syndrome)
—Yan, L.; Wang, W.; Qiu, Y.; Yu, C.; Wang, R.; Li, C. Int.Immunopharmacol. 2024, 112, 112704.
DOI: 10.1016/j.intimp.2024.112704.