• Application Note

Terfenadine and Related Compound

Terfenadine and Related Compound
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief highlights the analysis of Terfenadine and related compounds using Symmetry C8 Columns. 

Introduction

The compounds analyzed in this study are:

  1. Terfenadine
  2. Terfenadine Related Compound ARS 

Experimental

HPLC Method

Column:

Symmetry C8, 4.6 x 250 mm, 5 μm

Part number:

WAT054270

Mobile phase:

100 mM triethylammonium phosphate, pH 7.0/methanol 20:80

Flow rate:

1.0 mL/min

Injection volume:

A. 15 μL of mixture with 0.6 mg/mL terfenadine and 0.15 mg/mL of terfenadine related compound ARS

B. 15 μL of 8mg/mL crushed tablet (equivalent to 0.6mg/mL terfenadine)

Detection:

UV @ 235 nm

USP Tailing Factor

  1. 1.0 

Results and Discussion

Featured Products

WA31763.165, June 2003

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