ACQUITY Premier System

ACQUITY Premier System

The next evolution in separation science is here

The next evolution in separation science is here

Maximizing the sensitivity, repeatability, and robustness of your LC and LC-MS applications is critical. The ACQUITY Premier System is the next evolution of the Performance LC System which include the ACQUITY UPLC H-Class PLUS and ACQUITY UPLC I-Class PLUS Systems. Along with the reliability, ruggedness, high quality, and configuration flexibility you expect from the ACQUITY UPLC PLUS Series, the ACQUITY Premier System delivers a step change in chromatographic performance, lab efficiency, and risk control.

The ACQUITY Premier System features MaxPeak High Performance Surfaces (HPS) Technology, which offers improvements in separation and detection of metal-sensitive analytes, enabling you to minimize the risk of undetected analytes – for increased efficiency and confidence in your results.

The ACQUITY Premier System reduces adsorption losses due to metal interactions. ACQUITY Premier System

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Specifications

Maximum Operating Pressure  

15,000 psi

pH Range  

1 to 12.5 

Operating Flow Rate Range  

0.001 to 2.000 mL/min 

Injection type

Flow-Through Needle, Fixed Loop

Sample Flow Path   

Inert (MaxPeak HPS Technology)  

Sample Carryover  

≤0.002% 

Sample Compartment  

4 to 40 C 

Pump Options  

Binary, Quaternary  

Solvent Conditioning  

Active pre-heating as standard;

Column Tracking   

eCord Technology column information management tracks and archives column usage  

Column Capacity  

Six columns up to 150 mm length, up to 4.6 mm internal diameter (I.D.) 

Maximum Sample Capacity  

8,064 (with Sample Organizer)

Detector Options   

TUV Detector

PDA eλ Detector

FLR Detector

RI Detector 

ELS Detector 

Mass Spectrometers 

External Control   

Empower Software

MassLynx Software

waters_connect

Physical Specifications

QSM or BSM, SM-FTN, CH-A    

Width: 34.3 cm (13.5 in.)  

Height: 71.1 cm (28.0 in.) 

Depth: 71.2 cm (28.0 in.)  

Overview

  • Minimize risk of undetected analytes with MaxPeak High Performance Surfaces (HPS) Technology
  • Decrease time-to-result and increase overall efficiency by eliminating time-consuming system and column passivation
  • Improve peak shape and reproducibility for the most challenging metal-sensitive compounds
  • Achieve high-precision injections with direct inject sampling
  • Reduce time on method development
  • Multi-software platform support options with Empower, MassLynx, and UNIFI
  • Achieve sample injection versatility, depending upon your application, with the flow-through needle and fixed loop injector options

Recommended Use: For improving the peak shape and reproducibility for the most challenging metal-sensitive compounds.

Features Header

Features Header

Tough metal-sensitive compounds? Not anymore.

Non-specific adsorption of metal-sensitive compounds is an unpredictable challenge, leading to long system passivation times, chromatography with large RSDs, and broad peaks that can be a challenge to detect. The ACQUITY Premier System is built with proven ACQUITY technology, which offers true UPLC performance, ultra-low dispersion, and high resolution.

Designed with MaxPeak HPS Technology, the ACQUITY Premier System improves peak shape and reproducibility for the most challenging metal-sensitive compounds.

Boost method efficiency with UPLC technology

Take your methods to the next performance level by leveraging the benefits of Ultra Performance Liquid Chromatography (UPLC) technology to improve your existing HPLC methods. By scaling your methods to UPLC, your laboratory will benefit from the combination of increased resolution, sensitivity, and speed that comes with modern small-particle chemistries.

Along with fast UPLC analysis times, the ACQUITY Premier System reduces the need for system passivation to optimize assays for metal-sensitive compounds. Take your assays to the next level of efficiency, not only with faster analysis times, but also reduced system downtime, decreased reagent costs, and, ultimately, improved lab productivity.

Power up recovery and sensitivity

The ACQUITY Premier System minimizes metal-sensitive analyte loss, improving recovery and limits of detection. Couple the ACQUITY Premier System with a Waters mass spectrometer to confidently identify and quantify unknown compounds in complex samples and confirm trace components at the lowest possible levels.

Reproducible results with a reliable partner

The ACQUITY Premier System and ACQUITY Premier Columns are holistically designed to reduce analyte losses and improve repeatability for a diversity of metal-sensitive analytes that interact with metal surfaces in conventional LC technology. Waters also delivers world-renowned services and support, tailored to optimize your laboratory productivity while addressing budget realities. Our offerings help you maintain peak system performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements. 

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Related

Mass Spectrometry
Confidently identify known and unknown compounds with Waters Mass Spectrometry Systems. We have MS instruments to suit various workflows and applications.

MaxPeak Premier Columns
Experience the highest level of chromatographic performance, flexibility, and assurance while mitigating unwanted analyte/surface interactions with MaxPeak Premier Columns.

Offers and Discounts

Save 55% when you trade in your system
The FlexUP Technology Renewal Program provides customers with the opportunity to work with the latest, most advanced instruments.
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ACQUITY Premier System

The ACQUITY Premier System from Waters represents the next phase in separation science, offering unparalleled advancements in sensitivity, repeatability, and robustness for liquid chromatography (LC) and LC-MS applications. This system builds on the trusted ACQUITY UPLC H-Class PLUS and ACQUITY UPLC I-Class PLUS platforms, delivering the reliability, ruggedness, and high-quality performance you expect from the ACQUITY UPLC PLUS Series. The ACQUITY Premier System introduces enhancements in chromatographic performance, lab efficiency, and risk control, making it an indispensable tool for modern analytical laboratories.

Central to the ACQUITY Premier System is the MaxPeak High Performance Surfaces (HPS) Technology. This breakthrough technology minimizes the risk of undetected analytes by improving the separation and detection of metal-sensitive compounds. Traditional challenges with metal-sensitive analytes, such as non-specific adsorption, long system passivation times, and broad peaks, are effectively addressed, ensuring that your results are more reliable and reproducible.

With the ACQUITY Premier System, laboratories can achieve high-precision injections and improved peak shapes, even for the most challenging metal-sensitive compounds. The system offers a variety of sample injection options, including flow-through needle and fixed loop injectors, providing versatility to suit different application needs. By eliminating time-consuming system and column passivation, the ACQUITY Premier System decreases time-to-result and boosts overall efficiency.

The ACQUITY Premier System supports multiple software platforms, including Empower, MassLynx, and UNIFI, ensuring seamless integration into existing workflows. This compatibility enhances the flexibility and utility of the system, making it easier for laboratories to adopt and benefit from its advanced capabilities.

One of the standout features of the ACQUITY Premier System is its ability to scale existing HPLC methods to UPLC, leveraging the benefits of Ultra Performance Liquid Chromatography technology. This includes increased resolution, sensitivity, and speed, which significantly enhance method efficiency. Faster UPLC analysis times, coupled with reduced system downtime and decreased reagent costs, translate to improved lab productivity and cost savings.

The ACQUITY Premier System is particularly effective for the analysis of metal-sensitive compounds, as demonstrated by its superior performance in reducing the adsorption of complex peptides, such as insulin receptor-doubly phosphorylated peptide (TRDIpYETDpYYRK). This capability is crucial for accurately identifying and quantifying unknown compounds in complex samples, even at trace levels.

In addition to its technological advancements, the ACQUITY Premier System is supported by Waters' world-renowned services and support. This comprehensive support includes maintenance, troubleshooting, and optimization services that help laboratories maintain peak system performance, minimize downtime, and address scientific application challenges. Waters' commitment to stringent compliance requirements ensures that the ACQUITY Premier System meets the highest standards of regulatory and operational excellence.

The ACQUITY Premier System sets a new standard in separation science, offering unmatched sensitivity, repeatability, and robustness. Its innovative MaxPeak HPS Technology, coupled with the proven performance of ACQUITY UPLC technology, makes it an essential investment for any laboratory looking to improve chromatographic performance and efficiency. With Waters' dedicated support, the ACQUITY Premier System ensures reliable, reproducible results, empowering laboratories to achieve their analytical goals with confidence.

ACQUITY Premier System

1.What is MaxPeak High Performance Surfaces (HPS) Technology?
MaxPeak HPS Technology is an advanced surface treatment technology used in the ACQUITY Premier System to minimize the non-specific adsorption of metal-sensitive analytes. This technology improves peak shape, reproducibility, and detection of challenging compounds, enhancing overall chromatographic performance.

2. Can the ACQUITY Premier System be used with existing HPLC methods?
Yes, the ACQUITY Premier System can scale existing HPLC methods to UPLC, leveraging the benefits of increased resolution, sensitivity, and speed associated with Ultra Performance Liquid Chromatography (UPLC) technology.

3.What are the benefits of using UPLC technology with the ACQUITY Premier System?
UPLC technology offers faster analysis times, higher resolution, and greater sensitivity compared to traditional HPLC methods. This results in more efficient workflows, reduced reagent costs, and improved laboratory productivity.

4. What sample injection options are available with the ACQUITY Premier System?
The ACQUITY Premier System offers versatile sample injection options, including flow-through needle and fixed loop injectors. This allows users to choose the injection method that best suits their specific application requirements.