Xevo TQ Absolute Triple Quadrupole Mass Spectrometer

Xevo TQ Absolute Triple Quadrupole Mass Spectrometer

Absolute power to easily quantitate your most challenging compounds

Absolute power to easily quantitate your most challenging compounds

Achieve absolute confidence to reach lower limits of quantitation even for challenging negative ionizing compounds with an instrument that delivers absolute performance – the Xevo TQ Absolute.

An incredibly compact, more sustainable tandem quadrupole mass spectrometer, the Waters Xevo TQ Absolute enables your lab to achieve and maintain high performance and productivity. With Xevo’s consistent robustness, the Xevo TQ Absolute now enables you to quantify those challenging small mass, negative ionizing compounds with absolute sensitivity and confidence.  All with the reassurance your ESG commitments are being considered.

Xevo TQ Absolute Triple Quadrupole Mass Spectrometer

Specifications


Compare Xevo TQ Systems

Compare Xevo TQ Systems

Xevo TQ-S cronos

Xevo TQ-S cronos

Xevo TQ-S micro

Xevo TQ-S micro

Xevo TQ-XS

Xevo TQ-XS

Xevo TQ Absolute

Xevo TQ Absolute

Dimensions (w x h x d)

Dimensions (w x h x d)

Dimensions (w x h x d)

Dimensions (w x h x d)

Dimensions (w x h x d)

Dimensions (w x h x d)

35.6 x 60 x 93 cm

35.6 x 60 x 93 cm

61 x 70.7 x 99.5 cm

43 x 79 x 96 cm

Sensitivity key

Sensitivity key

Sensitivity key

Sensitivity key

Sensitivity key

Sensitivity key

★★

★★★

★★★★

★★★★★

Mass range

Mass range

Mass range

Mass range

Mass range

Mass range

2 to 2048 m/z

2 to 2048 m/z

2 to 2048 m/z

2 to 2048 m/z

Chromatographic configuration compatibility

Chromatographic configuration compatibility

Chromatographic configuration compatibility

Chromatographic configuration compatibility

Chromatographic configuration compatibility

Chromatographic configuration compatibility

ACQUITY Arc*

ACQUITY Premier

ACQUITY UPC2*

ACQUITY UPLC

ACQUITY UPLC M-Class*

ACQUITY Premier

ACQUITY UPC2*

ACQUITY UPLC

ACQUITY UPLC M-Class*

APGC*

ACQUITY Premier

ACQUITY UPC2*

ACQUITY UPLC

ACQUITY UPLC M-Class*

APGC*

ACQUITY Premier

ACQUITY UPLC

ACQUITY UPLC M-Class*

APGC*

Ion sources compatibility

Ion sources compatibility

Ion sources compatibility

Ion sources compatibility

Ion sources compatibility

Ion sources compatibility

APCI

ASAP*

ESCi*

ESI

UniSpray

APCI

APGC*

ASAP*

ESCi*

ESI

ionKey*

Nanoflow*

UniSpray

APCI

APGC*

ASAP*

ESCi*

ESI

ionKey*

Nanoflow*

UniSpray

APCI

APGC*

ASAP*

DESI XS*

ESCi*

ESI

Nanoflow*

UniSpray

Acquisition modes

Acquisition modes

Acquisition modes

Acquisition modes

Acquisition modes

Acquisition modes

Full scan

Product scan

Precursor ion scan

Constant neutral loss scan

Multiple reaction monitoring (MRM)

Simultaneous Full Scan and MRM (RADAR

Full scan

Product scan

Precursor ion scan

Constant neutral loss scan

Multiple reaction monitoring (MRM)

Simultaneous Full Scan and MRM (RADAR)

Full scan

Product scan

Precursor ion scan

Constant neutral loss scan

Multiple reaction monitoring (MRM)

Simultaneous Full Scan and MRM (RADAR)

Full scan

Product scan

Precursor ion scan

Constant neutral loss scan

Multiple reaction monitoring (MRM)

Simultaneous Full Scan and MRM (RADAR)

Detector **

Detector **

Detector **

Detector **

Detector **

Detector **

Low noise, off axis, long life photomultiplier**

Low noise, off axis, long life photomultiplier**

Low noise, off axis, long life photomultiplier**

Low noise, off axis, long life photomultiplier**

Ion source transfer optics

Ion source transfer optics

Ion source transfer optics

Ion source transfer optics

Ion source transfer optics

Ion source transfer optics

StepWave

StepWave

StepWave XS

StepWave XS

MRM speed

MRM speed

MRM speed

MRM speed

MRM speed

MRM speed

555 MRM/ sec

555 MRM/ sec

500 MRM/ sec

500 MRM/ sec

Regulatory approval ***

Regulatory approval ***

Regulatory approval ***

Regulatory approval ***

Regulatory approval ***

Regulatory approval ***

Third party software interfaces

Third party software interfaces

Third party software interfaces

Third party software interfaces

Third party software interfaces

Third party software interfaces

LIMS interface

MassLynx SkyLine interface

LIMS interface

MassLynx SkyLine interface

LIMS interface

MassLynx SkyLine interface

LIMS interface

MassLynx SkyLine interface

MassLynx security

MassLynx security

MassLynx security

MassLynx security

MassLynx security

MassLynx security

Yes

Yes

Yes

Yes

Software options

Software options

Software options

Software options

Software options

Software options

  • MassLynx v4.2
  • waters_connect for Quantitation
  • MassLynx v4.2
  • waters_connect for Quantitation
  • MassLynx v4.2
  • waters_connect for Quantitation
  • MassLynx v4.2
  • waters_connect for Quantitation

* Not available with waters_connect

** Less than 1% of Waters’ tandem quadrupole mass spectrometers require a detector replacement on an annual basis. [Source: Waters’ internal data on the service history of its tandem quadrupole mass spectrometers launched between 2006 and 2022]

*** Regulated approval marks include CE, CB, NRTL (Canada/USA), RCM


Overview

  • Absolute performance: Achieve lower limits of quantitation to meet regulatory requirements with up to 15x more sensitivity for challenging negative ionizing compounds than the previous product.
  • Absolute efficiency: Achieve improved environmental sustainability and lower your laboratory operational costs with an instrument that uses approximately 50% less electricity and gas and produces 50% less heat than most other high performance TQ mass spectrometry instruments on the market.
  • Absolute confidence: Ensure consistent robustness and reproducibility so you can maintain performance and productivity over a longer time period.
  • Absolute productivity: Boost your productivity with flexible software solutions, including waters_connect, the modern, intuitive  informatics platform that can save up to 50% of your data review time, while facilitating data integrity.

Recommended Use: Reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds.


Features Header

Features Header


Achieve absolute performance with improved sensitivity

To reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds, you need an instrument that delivers absolute performance. Xevo TQ Absolute delivers up to 15x better sensitivity for challenging negative ionizing compounds than the previous product, so you can make confident decisions, fast.


Improve sustainability and lower operational costs

Many businesses are trying to actively address environmental sustainability while also reducing operational costs. The Xevo TQ Absolute makes it possible to do just that. The Xevo TQ Absolute was developed to achieve lower electricity consumption, gas consumption, and BTU/hr output - lessening the need for air conditioning and lowering costs. The Xevo TQ Absolute also provides more analytical capability per square foot of lab space by minimizing the LC-MS/MS footprint, so laboratory managers can fully optimize their facilities and increase efficiency.



Waters Xevo TQ Absolute**

Waters Xevo TQ Absolute**

Relative Bench Width

100%

Power Consumption

1460W

Air Conditioning Demand (Heat Displacement)

4,980 Btu/h

Nitrogen/Zero-Grade Air Consumption

23 L/min

Audible Noise

59.2 dB


SCIEX™ 7500*

SCIEX™ 7500*

Relative Bench Width

184%

Power Consumption

3077W

Air Conditioning Demand (Heat Displacement)

10,500 Btu/h

Nitrogen/Zero-Grade Air Consumption

52 L/min

Audible Noise

68 dB

*Source: Accessed January 2022 related to document RUO-IDV-01-9809-G SCIEX Triple Quad 7500 LC-MS/MS System - QTRAP Ready Site Planning Guide

**Source: Xevo TQ Absolute Site Preparation Guide, power consumption range mid-point of 960 W + Ebara rough pump 500 W



Ensure absolute productivity with flexible software options

Achieve the ultimate flexibility to choose the right solution for your lab with our flexible software options for quantitation - the waters_connect and MassLynx software platforms. Our modern, app-based software platform waters_connect delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time and ensures your lab is as productive as possible. Meanwhile, our tried, well-established MassLynx Software package delivers superior versatility and flexibility across all application areas.


Maintain peak performance longer with robustness and reproducibility

Analytical laboratories face a number of evolving challenges, so absolute confidence that your analytical instrumentation can keep pace is critical. The Xevo TQ Absolute has been specifically developed to deliver consistent robustness and reproducibility to maintain performance and productivity over a longer time period. Achieve the best performance while minimizing contamination and reducing the need for inconvenient downtime to clean the instrument with the Xevo TQ Absolute’s optimal probe positioning guidance. Your lab can also maximize uptime by minimizing contamination of the source from sample matrix or mobile phase salts with the Xevo TQ Absolute’s new source shield.

Accelerating your success with award winning service

Ensure your laboratory runs efficiently and is ready to address the opportunities of tomorrow with Waters comprehensive analytical solutions with expert training (APS) and flexible and cost-effective solutions to advance your business with system service (FlexCHOICE), trade-ins and technological upgrades (FlexUP).

Resources

Documents

Documents

No Results Found


Support

Support

No Results Found

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Xevo TQ Absolute Triple Quadrupole Mass Spectrometer

The Xevo TQ Absolute Triple Quadrupole Mass Spectrometer is the pinnacle of sensitivity, efficiency, and sustainability, designed to overcome the most demanding analytical challenges with confidence. This state-of-the-art instrument delivers exceptional performance, enabling laboratories to quantify even the most challenging small mass and negative ionizing compounds with unmatched precision. Whether your goals are meeting stringent regulatory requirements or advancing scientific research, the Xevo TQ Absolute provides the tools to achieve success with ease.

Reaching lower limits of quantitation for complex compounds is no longer a challenge. The Xevo TQ Absolute provides up to 15 times greater sensitivity for difficult-to-analyze negative ionizing compounds compared to its predecessor, ensuring faster, more confident decision-making. Whether analyzing polar pesticides, small organic molecules, or other challenging analytes, this mass spectrometer offers the performance needed to meet regulatory requirements and exceed expectations in routine and advanced workflows.

The Xevo TQ Absolute helps laboratories meet their environmental, social, and governance (ESG) commitments without sacrificing performance. It consumes approximately 50% less electricity and gas, produces 50% less heat, and requires less air conditioning compared to other high-performance TQ mass spectrometers, significantly reducing operational costs. Its compact footprint optimizes laboratory space, providing more analytical capability per square foot and supporting sustainable, efficient lab management.

Designed to streamline workflows and maximize productivity, the Xevo TQ Absolute is supported by flexible software options, including waters_connect and MassLynx. The modern, app-based waters_connect platform offers intuitive features like Exception Focused Review (XFR), which can reduce data review time by up to 50%. Meanwhile, the trusted MassLynx software provides unparalleled versatility for diverse application areas, allowing laboratories to choose the solution that best fits their unique needs.

The Xevo TQ Absolute is built for consistent robustness and reproducibility, minimizing downtime and ensuring reliable operation over extended periods. Its advanced source shield and optimal probe positioning guidance reduce contamination from sample matrix or mobile phase salts, maintaining peak performance and decreasing maintenance frequency. This ensures uninterrupted workflows, maximizing uptime and efficiency in even the busiest laboratories.

Waters supports your success with award-winning service and training solutions tailored to your needs. From flexible service plans like FlexCHOICE to trade-in and upgrade programs like FlexUP, Waters offers comprehensive support to keep your laboratory running smoothly and ready for future challenges.

Compact, powerful, and environmentally conscious, the Xevo TQ Absolute Triple Quadrupole Mass Spectrometer sets a new standard for tandem quadrupole mass spectrometry. By combining superior sensitivity, reduced operational costs, and streamlined workflows, this instrument enables laboratories to achieve absolute confidence in their results while advancing sustainability goals.

Experience the Xevo TQ Absolute difference and unlock new possibilities for your most challenging analyses.

FAQs About the Xevo TQ Absolute Triple Quadrupole Mass Spectrometer

1. What types of compounds can the Xevo TQ Absolute analyze?
The Xevo TQ Absolute is designed to analyze a wide range of compounds, including small molecules, polar pesticides, pharmaceuticals, metabolites, and environmental contaminants. Its exceptional sensitivity for negative ionizing compounds makes it ideal for challenging analytes that are difficult to quantify with traditional mass spectrometry systems. The system's versatility allows it to handle complex sample matrices across industries, including food safety, environmental testing, clinical research, and pharmaceutical development.

2. What is the minimum limit of quantitation (LOQ) that can be achieved with this system?
The Xevo TQ Absolute is capable of achieving extremely low limits of quantitation (LOQs), even for challenging compounds. With sensitivity improvements of up to 15 times compared to previous models, it can reliably detect and quantify trace-level analytes in complex matrices. The exact LOQ depends on the specific application, analyte, and experimental conditions, but the system is engineered to meet stringent regulatory requirements for even the most demanding workflows.

3. How does the system minimize carryover and contamination during analysis?
The Xevo TQ Absolute incorporates advanced features to minimize carryover and contamination, ensuring consistent performance and reliable results. It uses programmable method settings to reduce residual analytes, while its optimized source shield protects the instrument from contamination caused by sample matrices and mobile phase salts. Additionally, precise probe positioning minimizes the risk of contamination, extending the instrument's uptime and reducing the need for frequent maintenance or cleaning.

4. How does the Xevo TQ Absolute reduce electricity and gas consumption?
The Xevo TQ Absolute is designed with sustainability in mind, consuming approximately 50% less electricity and gas than traditional high-performance triple quadrupole mass spectrometers. Its energy-efficient design also produces 50% less heat output, reducing the demand for air conditioning in the laboratory. This not only lowers operational costs but also supports environmental sustainability by reducing the lab's overall carbon footprint. These efficiency improvements make the Xevo TQ Absolute an environmentally conscious choice for modern analytical laboratories.