• Application Note

Pseudoephedrine HCL and Codeine

Pseudoephedrine HCL and Codeine
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief highlights the analysis of Pseudoephedrine HCL and Codeine using Symmetry Shield Columns. 

Introduction

The compounds analyzed in this study are:

  1. Pseudoephedrine HCL
  2. Codeine 

Experimental

HPLC Method

Column:

SymmetryShield RP8, 3.9 x 150 mm, 5 μm

Part number:

WAT200655

Mobile phase A:

50 mM potassium phosphate, pH 7

Mobile phase B:

Acetonitrile

Flow rate:

1.0 mL/min

Injection volume:

5 μL of 2 mg/mL pseudoephedrine and 0.2 mg/mL codeine

Detection:

UV @ 2541 nm

Gradient

USP Tailing Factors

  1. 1.8
  2. 1.1 

Results and Discussion

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WA31763.139, June 2003

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