Amino Acid Analysis

Amino Acid Analysis

Separate, identify, and quantitate amino acids accurately and efficiently with Waters amino acid analysis solutions. Waters combines instrumentation, sample preparation, columns, standards, and performance-qualified methods to help laboratory analysts achieve turnkey application success in protein characterization, cell culture monitoring, and nutritional analysis of foods and feeds.

Separate, identify, and quantitate amino acids accurately and efficiently with Waters amino acid analysis solutions. Waters combines instrumentation, sample preparation, columns, standards, and performance-qualified methods to help laboratory analysts achieve turnkey application success in protein characterization, cell culture monitoring, and nutritional analysis of foods and feeds.
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Scientist writing notes in lab

Overview

Amino acids are basic building blocks of proteins. Analyzing amino acids is required in various areas of research and development (R&D) and is fundamental in product analysis for food, beverages, and biotherapeutics. However, analyzing amino acids poses unique challenges due to their chemical and physical properties.

Overcome the challenges of maximizing protein yield and maintaining manufacturing consistency with Waters, with amino acid solutions to ensure precision and high throughput, addressing the needs of protein characterization, cell culture monitoring, and nutritional analysis of foods and feeds. Designed with exceptional reliability, Waters end-to-end solutions enable you to achieve precise qualitative and quantitative measurement of amino acids with exceptional sensitivity. Your lab benefits from shorter analysis time, method robustness to minimize variability, and accurate, confident results.

Applications

Scientists must ensure the correct composition and concentration of critical components in culture media as understanding consumption and metabolism is vital for optimizing cell growth, quality, and yield. Learn about Waters methods and workflows for the analysis of cell culture media with these application notes.

Scientists must ensure the correct composition and concentration of critical components in culture media as understanding consumption and metabolism is vital for optimizing cell growth, quality, and yield. Learn about Waters methods and workflows for the analysis of cell culture media with these application notes.

Application Notes

Application Notes

Application Notebook: Amino Acid Analysis

Learn about the Waters comprehensive system-based approach to amino acid analysis that leverages UPLC separations as well as application-specific columns, standards, and kits. This application notebook describes how Waters technologies can be applied across a variety of methods to perform amino acid analysis of hydrolysates, cell culture, foods and fees, and more.

Learn about the Waters comprehensive system-based approach to amino acid analysis that leverages UPLC separations as well as application-specific columns, standards, and kits. This application notebook describes how Waters technologies can be applied across a variety of methods to perform amino acid analysis of hydrolysates, cell culture, foods and fees, and more.
View Application Notebook
Amino Acid illustration

Solutions

Enhance efficiency and accelerate sample throughput with system solutions tailored to labs conducting amino acid analysis.

Enhance efficiency and accelerate sample throughput with system solutions tailored to labs conducting amino acid analysis.

Performance that advances your lab

Performance that advances your lab
ACQUITY UPLC H-Class PLUS System

Get the flexibility of quaternary or binary solvent blending with the advanced performance of UPLC technology with ACQUITY UPLC H-Class PLUS System, delivering increased resolution, sensitivity, and speed that comes with modern small particle chemistries.

  • Cell Culture Monitoring

The next evolution in separation science is here

The next evolution in separation science is here
ACQUITY Premier System

Maximize the sensitivity, repeatability, and robustness of your LC and LC-MS applications with the ACQUITY Premier System that features MaxPeak High Performance Surfaces (HPS) Technology for improvements in the separation and detection of metal-sensitive analytes.

  • Cell Culture Monitoring

See clearly and consistently, with confidence

See clearly and consistently, with confidence
Arc Premier System

Produce the most accurate, reliable, and reproducible data with the Arc Premier System for right first time robust results that features MaxPeak High Performance Surfaces (HPS) Technology to reduce non-specific adsorption due to metal interaction.

  • Cell Culture Monitoring

Efficient amino acid quantification to support process development

Efficient amino acid quantification to support process development
BioAccord LC-MS System

Enable LC-MS biopharmaceutical analyses in every lab with Waters BioAccord LC-MS System, including high-resolution MS and waters_connect software for compliance-ready data analysis and reporting.

  • Cell Culture Monitoring

Ensure your laboratory runs efficiently with Waters advanced software that provides quality and reliable results for increased productivity.

Ensure your laboratory runs efficiently with Waters advanced software that provides quality and reliable results for increased productivity.

Simplify data acquisition, processing, and reporting

Simplify data acquisition, processing, and reporting
Empower Chromatography Data System (CDS)

Equip your lab with Empower Chromatography Data System (CDS) and gain advanced laboratory data management for your amino acid analyses, including acquisition, processing, and reporting for liquid and gas chromatography instruments.

  • Cell Culture Monitoring

 Streamline data analysis and processing

 Streamline data analysis and processing
waters_connect for biopharmaceuticals

Accelerate the journey from sample analysis to decision-making with waters_connect for biopharmaceuticals that offers dedicated apps and workflows for MAM, intact mass analysis, sequence confirmation, and more.

  • Cell Culture Monitoring

Effortlessly transition from laborious manual pipetting procedures to automated processes with Lab Automation solutions from Waters.

Effortlessly transition from laborious manual pipetting procedures to automated processes with Lab Automation solutions from Waters.

Automate the tedious to focus on the critical

Automate the tedious to focus on the critical
Andrew+ Pipetting Robot

Obtain automated liquid handling with Waters Andrew+ Pipetting Robot that offers electronic pipettes and innovative labware holders. By adding connected tools for processes such as heating or labware transportation with Device+, you gain a full walk-away automation solution.

  • Cell Culture Monitoring

Our reliable and robust columns and consumables easily integrate into your amino acid analysis workflows.

Our reliable and robust columns and consumables easily integrate into your amino acid analysis workflows.

Accurate amino acid composition analysis for HPLC, UHPLC, and UPLC

Accurate amino acid composition analysis for HPLC, UHPLC, and UPLC
AccQ∙Tag Ultra Derivatization Kits and Reference Standards

Separate, identify, and quantitate amino acids with Waters Amino Acid Analysis Standards & Kits, a complete automation-enabled, application-specific workflow solution that includes eluents, standards, derivatization reagents, columns, and methods for fast results.

  • Cell Culture Monitoring

Accurate amino acid composition analysis starts here

Accurate amino acid composition analysis starts here
AccQ•Tag Columns for Amino Acid Analysis

Ensure repeatable performance for your most demanding amino acid analysis with AccQ•Tag Columns for Amino Acid Analysis that are designed for use on Waters HPLC, UHPLC and UPLC platforms and deliver rapid separation with superior resolution.

  • Cell Culture Monitoring

Achieve testing efficiencies and accurate results using streamlined Waters services and support.

Achieve testing efficiencies and accurate results using streamlined Waters services and support.

Your success is just a click away

Your success is just a click away
Waters Global Services

Optimize your laboratory's productivity and success with Waters Global Services. Maintain peak system performance, minimize downtime, address application challenges, and support stringent compliance requirements.

  • Cell Culture Monitoring
  • Product Quality Attributes Monitoring

Make science more accessible

Make science more accessible
Payment Solutions

Maximize resources and minimize risk with payment options from Waters Capital, including upgrading aging equipment, getting customized support, and bundling services into one monthly payment.

  • Cell Culture Monitoring
  • Product Quality Attributes Monitoring

The data speaks for itself

The data speaks for itself
Analysis of Protein Hydrolysate standard on the AccQ•Tag Ultra C18, 2.5 µm 4.6 x 150 mm Column batch-to-batch reproducibility.
Analysis of a hydrolysate standard at 10 pmol/mL. The UPLC Amino Acid Analysis Solution provides high resolution to ensure method robustness with good quantitation. The short cycle time is obtained without compromising accurate results.
Representative chromatogram of the amino acid cell culture standard acquired on the ACQUITY UPLC H-Class PLUS Binary System. The sample concentration was 500 µM for all amino acids, except cysteine which was 250 µM.
Protein Hydrolysate AA Standard (500 µM) using an AccQ•Tag Ultra C18 2.5 µm Column on an ACQUITY Arc System.
Protein Hydrolysate AA Standard (500 µM) chromatogram using an AccQ•Tag Ultra C18 2.5 µm Column on an Arc HPLC System.
Schematic overview of sample preparation, LC-MS analysis, and report for cell culture media nutrient and metabolite analysis based on Andrew+ Pipette Robot and BioAccord LC-MS platform.

Webinars and Resources

  • Case Study

Ajinomoto, a Waters Success Story

Ajinomoto, a Waters Success Story
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  • Infographic

Biopharma Solutions

Biopharma Solutions
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  • Brochure

UPLC Amino Acid Analysis Solution

UPLC Amino Acid Analysis Solution
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  • Infographic

Andrew+ for Biopharmaceuticals

Andrew+ for Biopharmaceuticals
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  • Primer

Comprehensive Guide to Hydrolysis and Analysis of Amino Acids

Comprehensive Guide to Hydrolysis and Analysis of Amino Acids
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Related

Amino Acids Testing
Ensure product nutrition labeling compliance and adhere to food manufacturing specifications with Waters amino acid analysis solutions for accurate, simplified testing of food, beverage and feed samples.

Amino acids Testing in Food
Confirm products meet specifications and nutritional label claims with Waters manual and automated solutions for amino acid testing, enabling laboratories.

Learn more about Amino Acid Analysis Solutions.

Learn more about Amino Acid Analysis Solutions.
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