Discovery lipidomics aims to measure a biological system’s complete set of lipids in an unbiased manner. The diversity of chemical composition and natural abundance levels challenge chromatographic and mass spectrometric performance. Waters discovery lipidomics solutions are developed to deliver comprehensive lipidome coverage that includes:
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Maximize sensitivity, repeatability, and robustness of your LC and LC-MS applications with ACQUITY Premier System. It offers improvements in separation and detection of metal-sensitive analytes, enabling you to minimize the risk of undetected analytes – for increased efficiency and confidence in your results.
Developed through focused collaboration, the SELECT SERIES Cyclic IMS combines novel cyclic ion mobility separation with state-of-the-art high performance, time-of-flight mass spectrometry, enabling leading researchers to unlock the potential in scientific discovery.
Identify the spatial localization of sample components quickly and easily with increased sensitivity using DESI XS, the high-performance sprayer that makes it possible to visualize compounds at previously unobtainable levels.
Accelerate your research and comprehensively identify analytes in your complex samples with the SELECT SERIES MRT, built with state-of-the-art Multi Reflecting Time-of-Flight (MRT) technology.
Obtain ultimate flexibility and freedom of analytical choice to support scientific creativity and technical success with SYNAPT XS that incorporates SONAR and HDMS to efficiently interrogate your complex mixtures.
Maximize sample information for your analytes from detailed characterization to accurate quantitation with the Xevo G3 QTof, which enables complete confidence in your results.
An example of a high-confidence identification. In this example feature, 760.5879@4.14 is identified as PC (34:1). The MS/MS spectrum is available and all the components (i.e., acyl chains) of the proposed lipid are readily identified (dark-green label).
Chromatograms representing a plasma extract (ESI-) with the various lipid groups highlighted based on RT. Inset is the RT distribution gained for a number of the lipid standards measured.
Retention time reproducibility for selected injection numbers 1, 50, and 100 based on LPC(16:0) m/z 496.34, PC(16:0_18:1) m/z 758.57, SM(d18:1_24:1) m/z 813.69, and TAG(52:3) m/z 874.79 with average retention time RSD value <0.19% (n=100).
Chromatographic analysis of the Avanti lipid differential ion mobility lipid mix using the RAMMP lipid methodology.
