HPLC Columns

HPLC Columns

50+ years of quality column manufacturing delivers reproducibility and transferability you can trust.

50+ years of quality column manufacturing delivers reproducibility and transferability you can trust.

Choose from the widest range of analytical and preparative columns, meeting the needs of virtually every application.

Meet all your lab’s method development needs with Waters fit-for-purpose particles and chemistries. Resolve your toughest HPLC separation challenges with 2,500+ column formats, 100+ column configurations, and 25+ unique column phases from Waters, a leader in batch-to-batch reproducibility.

Try our newly expanded line of XBridge Premier Columns and XSelect Premier Columns, now available in 3.5 µm particle size. 

Explore your new favorite solid-core HPLC column. 5 µm CORTECS Premier Columns are here.

Not sure where to start? Get help with the Column Coach.

Shop XBridge Premier
Shop XBridge
  • BEH (Ethylene Bridged Hybrid) columns — best in class stability at low and high pH
  • Compatible with a variety of mobile phase additives or buffers for faster method development
  • Universal columns ideal for a wide range of compounds
  • Multiple pore diameters available, optimized for a comprehensive selection of molecule sizes
Shop XSelect Premier
Shop XSelect
  • Offers the widest selectivity range of base particles and ligands
  • Ideal for method scouting and development
  • Suited for all types of samples for HPLC & LC-MS analysis
  • CSH (Charged Surface Hybrid) columns — best peak shape for basic compounds at low pH
  • HSS (High Strength Silica) columns — increased retention for polar and non-polar compounds
Shop Atlantis Premier
Shop Atlantis
  • Exceptional retention for polar compounds
  • Family including multiple separation modes, such as reversed-phase, mixed-mode, and HILIC
  • T3 provides balanced retention for broad analyte mixtures
  • Reversed-phase columns compatible with 100% aqueous mobile phases
  • Long column lifetimes with low mobile phase pH
Shop Cortecs Premier
Shop Cortecs
  • Highest resolution with increased column efficiency
  • Lower column backpressures enabling increased flowrates and throughput
  • Batch-to-batch reproducibility for expected results
  • Excellent low pH stability for longer column lifetimes
  • Solid-core technology
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  • High purity silica columns manufactured to meet the highest reproducibility standards
  • Provide excellent peak shape for basic analytes
  • Symmetry Shield bonded phases feature an embedded polar group to provide alternative selectivity
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  • Proprietary bonding process provides higher stability under acidic conditions
  • Superior mass loading at low pH
  • Excellent performance and lifetime with TFA

Product Reviews

“For LC researchers, XBridge is a must column to be in rack.”

— Teva

“For LC researchers, XBridge is a must column to be in rack.”

— Teva

“When we have a polar compound, we just select the Atlantis method, and it gives us nice retention and peak shapes.”

— Mercachem

“When we have a polar compound, we just select the Atlantis method, and it gives us nice retention and peak shapes.”

— Mercachem

“The XSelect column really is my go-to column for standard analysis.”

— PPG Coatings

“The XSelect column really is my go-to column for standard analysis.”

— PPG Coatings

“This column (SunFire) provides robust lot to lot behavior with high number of injections per column.”

— Intas Pharmaceuticals

“This column (SunFire) provides robust lot to lot behavior with high number of injections per column.”

— Intas Pharmaceuticals

Scientist reaching for glass bottle in a brightly lit lab with an Arc Premier system near her

Innovation never stops at Waters Corporation

That includes HPLC Columns. Our new MaxPeak Premier Columns featuring MaxPeak High Performance Surfaces help you get the right answer the first time, and every time. By eliminating unwanted, uncontrolled interactions between metal column surfaces and your analytes of interest, HPLC column users experience improvements in reproducibility, peak shape, area counts and turn around time. All without sacrificing the flexibility and efficiency you expect from an HPLC column.

Discover MaxPeak Premier
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Want to discover more HPLC columns?

Want to discover more HPLC columns?
View Waters full portfolio of HPLC column offerings

Need lab-scale HPLC purification?

Need lab-scale HPLC purification?
View Waters full portfolio of preparative HPLC column offerings

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