Speed, resolution, and sensitivity. You can have it all.

Speed, resolution, and sensitivity. You can have it all.

20 years ago, Waters enabled scientists to break the traditional barriers in speed, sensitivity and resolution in chromatographic separations with the launch of ACQUITY UPLC Columns and Performance LC Systems. The combination of sub-2-µm columns and low dispersion systems created a new separation category, and the world has never looked back.

ACQUITY UPLC H-Class System with ACQUITY Premier Peptide Column on greenery background

Maximizing the sensitivity, repeatability, and robustness of your LC and LC-MS applications is critical. With Waters Performance UPLC Systems, you can improve separation resolution and reproducibility, enhance selectivity across molecule types and matrix complexities, and get peak chromatographic performance for complex applications with sub-2-µm particle columns. Our portfolio of Performance systems are typically paired with MS technologies and include the ACQUITY UPLC H-Class PLUS, ACQUITY UPLC I-Class PLUS, and ACQUITY Premier Systems.

Get the flexibility your lab needs to meet your method requirements with more than 200 combinations of column configurations and chemistries. Achieve faster separations with higher resolutions and sensitivities with UPLC (sub-2-µm) Columns, which harness the full potential of small particles with reduced solvent usage — ideal for helping your lab create more environmentally-friendly methods. All Waters UPLC Columns are designed, tested, and guaranteed for routine use in applications up to 18,000 psi (1241 bar).

  • Up to 92% faster speed*
  • Up to 50% more sensitivity*
  • Up to 38% more resolution*

*Data is from ACQUITY UPLC Columns, as compared to HPLC columns packed with 5 μm particles.

20 Years of UPLC Technology

2004

2004

ACQUITY UPLC System

BEH Columns

2010

2010

ACQUITY UPLC H-Class System

CSH Columns

2011

2011

ACQUITY UPLC I-Class System

HSS Columns

2013/2014

2013/2014

ACQUITY UPLC M-Class System

CORTECS Columns

2018

2018

ACQUITY UPLC H-Class PLUS System

ACQUITY UPLC I-Class PLUS System

2020

2020

ACQUITY Premier System

MaxPeak Premier Columns

Learn more about Waters history in chromatography

Explore Waters UPLC Columns

Shop Acquity Premier
Shop ACQUITY
  • Reduce non-specific adsorption losses due to metal interactions
  • Increase speed, sensitivity and resolution
  • Mass spectrometry (MS) compatible
  • Wide range of selectivities and pH range compatibility
  • Excellent batch to batch reproducibility
  • ACT Labeled
Shop Atlantis Premier
  • Reduce non-specific adsorption losses due to metal interactions
  • Increase retention of polar acid analytes
  • Mixed-mode, reversed-phase/anion-exchange (AX) chemistry
  • Increase stability over a wider pH range
  • Mass spectrometry (MS) compatible
  • ACT Labeled
Shop CORTECS Premier
Shop CORTECS
  • Reduce non-specific adsorption losses due to metal interactions
  • Highest resolution
  • Increased column efficiency at low backpressures
  • Reliable data for all analytes at higher throughput
  • Improved peak shapes
  • Solid-Core Technology
  • ACT Labeled

Go Green with UPLC Columns

Green chemistry is the concept of using less harmful resources that can negatively impact the environment and human health.

Waters UPLC Columns help your lab create methods that are more environmentally friendly. Sub-2-µm particle sizes allow faster methods without sacrificing resolution to reduce solvent usage, ultimately leading to reduced waste disposal costs.

Download the Green Chemistry Pocket Guide
Reduce Overall Cost, Time, and Environmental Impact with Waters Green Chemistry Infographic

Ready to go green?

Ready to go green?
  • Choose columns that help reach your sustainability goals by selecting ACT. Environmental Impact Factor Label columns. Includes ACQUITY Premier and CORTECS Premier sub-2-µm Columns. Learn more >
  • Switch to less toxic solvents, e.g., isopropyl alcohol (IPA) instead of acetonitrile (ACN).
  • Modernize your method to smaller particle sizes and shorter columns, reducing use of toxic solvent and reducing method run time.
  • Use a guard column, ensuring your column lasts longer and reducing steel waste.
Monitor for the presence of toxic plant toxins that can enter the food chain as constituents of plant products used in food processing or from seeds and leaves of weeds mixed accidentally with the main food crop at harvest.

Over 1,000,000 columns sold​

Over 1,000,000 columns sold​

~300 million hours of runtime saved1​

~300 million hours of runtime saved1​

~27 million liters of mobile phase saved2

~27 million liters of mobile phase saved2

25,000+ publications and growing3

25,000+ publications and growing3

23 selectivities available

23 selectivities available

All stats based on 1000 injections/column​

1 Based on a 30-minute HPLC run vs. 10-minute UPLC run  |  2 HPLC 1.0 mL/min vs. UPLC 0.3 mL/min​  |  3 Scopus search for ACQUITY or UPLC, Dec 2023​

Explore Waters UPLC Systems

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  • Flexibility of quaternary or binary solvent blending
  • High-precision injections with direct inject sampling
  • Accurate temperature control across the entire column
  • Managed dwell volume
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  • Achieve precise and accurate binary solvent blending
  • Get sample injection versatility
  • Manage ultra-low carryover through programmable method settings
  • Get accurate temperature control across the entire column
  • Improve the performance of any mass spectrometer with the highest chromatographic resolution
Learn More
  • Higher sensitivity for any mass spectrometer (MS)
  • Maximum amount of data from any sample
  • Less sample preparation volume and cost
  • Reduced solvent consumption
  • Increased dynamic range
Learn More
  • Minimize risk of undetected analytes
  • Decrease time-to-result and increase overall efficiency
  • Improve peak shape and reproducibility for the most challenging metal-sensitive compounds
  • Achieve high-precision injections with direct inject sampling
  • Reduce time on method development
  • Achieve sample injection versatility

Waters: Committed to Green By Design

Waters Precision Manufacturing Facility in Taunton is the first and only Leadership in Energy and Environmental Design (LEED)-Certified chemical manufacturing facility in Massachusetts – reducing energy consumption, hazardous waste, and water usage, for plant-wide emissions reduction by a factor of three.

Watch the Tour

Don’t take our word for it.

Learn more about Waters UPLC Solutions.

Learn more about Waters UPLC Solutions.
Ensure confidence in your separations with ACQUITY QDa II Detector.
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