REIMS Research System with iKnife Sampling Device
Direct molecular profiling in seconds
Waters Rapid Evaporative Ionization Mass Spectrometry (REIMS) Research System with iKnife Sampling Device combines direct-from-sample ionization with high-performance time-of-flight (Tof) MS and powerful, intuitive informatics, for fast, and easy molecular profiling with zero sample preparation.
The innovative iKnife handheld sampling device produces information-rich vapor directly from the sample surface, which when analyzed by a Tof MS, provides analysts with an accurate molecular profile within seconds.
The combination of these two technologies enables users in applications such as food, microbiology, and pre-clinical tissue research to quickly and easily differentiate samples from one another and confidently identify the differentiating features, allowing greater insight into the chemical, and biological systems under investigation.
For research use only. Not for use in diagnostic procedures.
REIMS Research System with iKnife Sampling Device
Overview
- Achieve fast and direct ionization without any sample preparation or chromatography
- Enhance data quality and manage multiple replicates and large data sets conveniently and efficiently
- Differentiate sample groups and highlight significant sample features with easy-to-use multivariate statistics
- Employ flexible compound search methods, compatible with popular databases for quick, and accurate sample identification
- Review data, employ pathway analysis, and integrate with other informatics with effective visualization tools
Recommended Use: For quick and easy molecular profiling without sample preparation or chromatography.
Features Header
No sample preparation or chromatography required
MS-based analysis of complex sample matrices often requires sample preparation and chromatographic separation prior to the MS detection. This approach can be time consuming and costly, particularly when large numbers of samples or replicates are required. It can also be technically challenging and can introduce unwanted selectivity to the analysis.
The REIMS Research System with iKnife Sampling removes the need for sample preparation and chromatographic separation, allowing your lab to collect an accurate mass MS profile in just a few seconds per sample. This saves time and money and makes it easier than ever before to obtain detailed molecular information from a range of sample types.
Furthermore, the long, flexible connection between the iKnife handheld sampling device, and the MS allows greater freedom of movement than any other ionization technique, bringing the analysis to the sample.
Quickly determine differences within and between samples
With molecular profile data collected from multiple samples of similar type or origin, it is often not possible to determine significant differences by visual inspection, especially since the differences are often represented by changing ratios of multiple components rather than the presence or absence of a few key species.
LiveID Software offers an intuitive, workflow-based approach to process large data sets using powerful multivariate statistical methods. This quickly highlights similarities and differences between samples, allowing them to be grouped in an objective, and unbiased way.
Identify molecular markers responsible for sample differences
Once samples have been grouped according to their similarities and differences, it is important to understand the reasons for those differences in order to provide a more detailed understanding of the chemical or biological system under investigation.
Progenesis QI highlights spectral features that cause the differentiation between sample groups, and then uses the accurate mass MS data to search databases and identify the molecular markers. These identifications can then be confirmed for a greater level of confidence, for example by conducting targeted tandem mass spectrometry (MS/MS) experiments to obtain additional structural information.
Compatible with IMS MS/MS or MS/MS
Waters quadrupole time-of-flight (QTof) systems provide the ideal platform for REIMS with iKnife Sampling, with superior performance, proven robustness, reliability, and the flexibility to adapt to changing priorities and future needs.
SYNAPT XS HRMS – For ultimate flexibility and freedom of analytical choice
- SONAR and HDMSE provide a unique toolkit for interrogating complex mixtures
- Ion mobility multiplies peak capacity and analysis selectivity
- CCS measurements increase security of compound identification
Xevo G3 QTof – For complete coverage for confident characterization
- Maximum coverage of analytes
- Harmonize workflows across the organization
- Improve quantitative capabilities for screening and targeted applications
Holistic profiling approach with UPLC-MS
Both SYNAPT XS HRMS and Xevo G3 QTof are compatible with a wide range of Waters chromatography inlets and ionization sources. This allows aliquots of the same sample to be analyzed on a single mass spectrometry system using multiple different analytical techniques, for example REIMS, UPLC-MS, and GC-MS, towards a holistic profiling approach.
Inlet Options
UPLC, Nanoflow UPLC, UPC2, GC, APC
Ionization Options
ESI, nanoESI, ionKey/MS, APGC, APCI, ESCI, ASAP, DESI, MALDI*, REIMS
*MALDI available on SYNAPT XS HDMS only
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