SFC Prep 150 Mgm System
A greener approach to high-throughput purification
Many of today’s laboratories are looking to adopt a greener approach to high throughput purification. Designed for high-throughput, semi-prep to preparative scale purifications, the SFC Prep 150 Mgm System is made for repeat injection (bulk purification) of chiral and achiral compounds.
The SFC Prep 150 Mgm System operates at flow rates higher than traditional high-performance liquid chromatography (HPLC) systems without significant increases in back pressure – allowing for high-speed supercritical fluid chromatography (SFC) purification, improved resolution of compounds, and higher purity isolations.
SFC Prep 150 Mgm System
Specifications
Overview
- Achieve high-speed SFC purification and improved resolution of compounds, leading to higher purity isolations
- Reduce normal-phase solvent usage and disposal
- Benefit from increased usability with the new intuitive graphical interface of Chromscope 2.1 SFC Software supported by Windows 10
- Achieve faster equilibration, lower pressure drops across the column, solvent reduction, and lower cost per sample with Waters SFC Prep 150 Mgm
Recommended Use: For laboratories seeking to adopt a greener approach to high-throughput purification.
Features Header
A greener approach to high-throughput purification
The Waters SFC Prep 150 Mgm System is perfectly suited for laboratories seeking to adopt a greener approach to high throughput purification. The SFC Prep 150 Mgm System is the ideal choice when reduction of normal-phase solvent usage and disposal is a critically important step for purification laboratories wanting to become more environmentally friendly.
SFC systems utilize liquid carbon dioxide (CO2) as its main mobile phase in combination with one or more organic solvents, resulting in faster equilibration, lower pressure drops across the column, solvent reduction, and lower cost per sample. The process is reproducible and applicable to a wide range of compounds relevant in the pharmaceutical, life sciences, chemical materials food, and environmental markets.
Achieve higher purity isolations
The SFC Prep 150 Mgm System has a maximum flow rate, CO2 and co-solvent combined, of up to 150 mL/minute allowing use of 19 mm and 30 mm columns. It also has capacity for six fraction collection positions (two liters each).
The user can take advantage of a new intuitive graphical interface controlled by the Waters ChromScope 2.1 SFC Software supported by Windows 10. The SFC Prep 150 Mgm System operates at flow rates higher than traditional HPLC systems without significant increases in back pressure, allowing for high-speed SFC purification and improved resolution of compounds, leading to higher purity isolations. ChromScope v2.1 is an updated version of ChromScope Software that enables support of the Waters SFC Prep 150 Mgm System with the ACQUITY QDa Mass Detector. Additionally, this update adds support for ELSD and the Isocratic Solvent Manager.
System features that support increased throughput
The SFC Prep 150 Mgm System is designed to improve productivity with a greener approach to high-throughput purification, with features like:
- QGM Quaternary Gradient Pump: This pump delivers flowrates up to a maximum of 150 mL/min serves as the co-solvent delivery device for this system.
- P200X CO2 Pump: This high-pressure delivery pump has dual stainless-steel heads with a cam driven sapphire piston assembly; self-priming check valves; pressure sensor; pressure gauge; brushless motor, and a rupture disc assembly. The pump is designed to improve performance with feedback from the pressure sensor and mass flowmeter.
- Modifier Stream Injector: Designed to support customer requests for modified-stream injection, this device injects one sample at a time using a standard 2 mL loop and a 5 mL syringe. This allows for settable air gaps on either side of the sample, which function as a buffer between the solvent and the sample, decreasing dilution.
- Prep Collection Cabinet: This collection cabinet comes with a retractable front door allowing for easy insertion and removal of 2 liter fraction bottles. The collection cabinet has an exhaust port in the upper backside of the cabinet to easily fit laboratories around the world, and comes standard with a removable spill tray.
- Effortless integration with the ACQUITY QDa Mass Detector: The intuitive design of the ACQUITY QDa Mass Detector provides the additional data you need without the cost and complexity of traditional mass spectrometry systems and software, giving you the analytical confidence that the selectivity of mass detection brings to your analysis.
