Demand for anti-doping testing is rising to comply with World Anti-Doping Agency (WADA) guidelines, resulting in the need for quick, accurate, reliable, and robust methods for screening and confirming a large number of samples. With Waters suite of LC-MS/MS instrumentation, we can provide your lab with total solutions for your analysis of illegal and banned substances.
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Waters LC-MS/MS solutions provide exceptional performance, ease of use and robust data for drug panels.
The combination of ACQUITY UPLC I-Class PLUS System with Waters line of mass spectrometry provides the highest chromatography resolution for accurate quantitation in routine drug analysis.
Achieve exceptional performance, delivering ease of use and robust high-quality data in a small footprint for a tandem quadrupole mass spectrometer.
Achieve and maintain high performance and productivity with significantly increased sensitivity for negative ionizing compounds with our compact, sustainable tandem quadrupole mass spectrometer.
Xevo G3 QTof brings the power of accurate mass and versatility of high-resolution mass spectrometry to the forensic toxicology laboratory for targeted and non-targeted screening analysis.
Chromatography of beta-blockers and diuretics. All compounds eluted within four minutes.
Results of the binary comparison analysis for furosemide (the plot is scaled to the relative percentages of the identified fragments). The data have been generated using the binary compare tool in UNIFI and highlight the mass error between the standard (upper-trace) and the sample data (lower-trace).
Matrix effects for beta-blockers and diuretics. Mean matrix effects from 12 lots of urine were compared to matrix effects from 1:5 and 1:10 dilution of pooled blank urine in 97:2:1 H2O:ACN:formic acid. Even at 1:10 dilution, ion suppression was significantly increased in the diluted samples compared to those prepared by SPE with the MAX µElution plate (N=12 for mean SPE matrix effects and N=4 for the diluted samples). Asterisks indicate compounds in which matrix effects were NOT different between SPE prepared and diluted samples.
Data for benzthiazide in a blank urine sample that has been spiked at the WADA MRPL (200 ng/mL); additional confirmation is achieved by the presence of three fragment ions in the high energy function.
