UPLC Columns

UPLC Columns

Speed, resolution, and sensitivity. You can have it all.

Speed, resolution, and sensitivity. You can have it all.
An ACQUITY PREMIER Peptide column on top of greenery

Get the flexibility your lab needs to meet your method requirements with more than 200 combinations of column configurations and chemistries. Achieve faster separations with higher resolutions and sensitivities with UPLC (sub-2 µm) Columns, which harness the full potential of small particles with reduced solvent usage — ideal for helping your lab create more environmentally-friendly methods.

All Waters UPLC Columns are designed, tested, and guaranteed for routine use in applications up to 18,000 psi (1241 bar).

  • Up to 92% Faster Speed*
  • Up to 50% More Sensitivity*
  • Up to 38% More Resolution*

*As compared to HPLC columns packed with 5 μm particles.

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Go Green with UPLC Columns

Green chemistry is the concept of using less harmful resources that can negatively impact the environment and human health.

Waters UPLC Columns help your lab create methods that are more environmentally friendly. Sub-2µm particle sizes allow faster methods without sacrificing resolution to reduce solvent usage, ultimately leading to reduced waste disposal costs.

Ready to go green?

Ready to go green?
  • Switch to more eco-friendly solvents, e.g., isopropyl alcohol (IPA) instead of acetonitrile (ACN).
  • Modernize your method to smaller particle sizes and shorter columns, reducing use of toxic solvent and reducing method run time.
  • Use a guard column, ensuring your column lasts longer and reducing steel waste.
Download the Green Chemistry Pocket Guide
Reduce Overall Cost, Time, and Environmental Impact with Waters Green Chemistry Infographic
Monitor for the presence of toxic plant toxins that can enter the food chain as constituents of plant products used in food processing or from seeds and leaves of weeds mixed accidentally with the main food crop at harvest.

Waters: Committed to Green By Design

Waters Precision Manufacturing Facility in Taunton is the first and only Leadership in Energy and Environmental Design (LEED)-Certified chemical manufacturing facility in Massachusetts – reducing energy consumption, hazardous waste, and water usage, for plant-wide emissions reduction by a factor of three.

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Explore Waters UPLC Columns

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  • Increase resolution
  • Enhance sensitivity
  • Higher throughput
  • Improve peak shapes
  • Batch-to-batch reproducibility for expected results
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  • Reduce non-specific adsorption losses due to metal interactions
  • Increase reproducibility
  • Enhance sensitivity
  • Improve peak shapes
  • Reduce risks associated with unpredictable chromatography
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  • Reduce non-specific adsorption losses due to metal interactions
  • Increase retention of polar acid analytes
  • Mixed-mode, reversed-phase/anion-exchange (AX) chemistry
  • Increase stability over a wider pH range
  • Mass spectrometry (MS) compatible
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  • Highest resolution with increased column efficiency
  • Lower column backpressures enabling increased flowrates and throughput
  • Batch-to-batch reproducibility for expected results
  • Excellent low pH stability for longer column lifetimes
  • Solid-Core Technology
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  • Reduce non-specific adsorption losses due to metal interactions
  • Highest resolution
  • Increased column efficiency at low backpressures
  • Reliable data for all analytes at higher throughput
  • Improved peak shapes
  • Solid-Core Technology

Product Reviews

“These (ACQUITY UPLC) columns just don't quit. They last forever, can be used for a variety of sample types and solvents, easy to use, easy to develop methods with.”

— Bayer CropScience

“These (ACQUITY UPLC) columns just don't quit. They last forever, can be used for a variety of sample types and solvents, easy to use, easy to develop methods with.”

— Bayer CropScience

“The CORTECS range are now the go to columns for UPLC application in our lab. Improved resolution and sensitivity over anything we have seen so far.”

— The Scotch Whisky Research Institute

“The CORTECS range are now the go to columns for UPLC application in our lab. Improved resolution and sensitivity over anything we have seen so far.”

— The Scotch Whisky Research Institute

“Good and robust column for the analysis of a selection of polar drugs of abuse…The stability for a broad pH range and possibility of starting conditions with 100% water make this column (Atlantis Premier Column) great for this application.”

— Netherlands Forensic Institute

“Good and robust column for the analysis of a selection of polar drugs of abuse…The stability for a broad pH range and possibility of starting conditions with 100% water make this column (Atlantis Premier Column) great for this application.”

— Netherlands Forensic Institute

“This column (ACQUITY Premier Column) outperforms all other columns in our laboratory when it comes to peak shape.”

— UiT The Arctic University of Norway

“This column (ACQUITY Premier Column) outperforms all other columns in our laboratory when it comes to peak shape.”

— UiT The Arctic University of Norway

Two scientists in Waters laboratory with an ACQUITY Premier, XEVO TQ Absolute, and waters_connect/MS Quan
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