• Application Note

Quinidine Sulfate and Related Substance

Quinidine Sulfate and Related Substance
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief highlights the analysis of quinidine sulfate and related substance using Symmetry Shield Columns. 

Introduction

The compounds analyzed in this study are:

  1. Quinidine sulfate
  2. Dihydroquinidine sulfate 

Experimental

HPLC Method

Column:

Symmetry Shield RP18, 4.6 x 250 mm, 5 μm

Part number:

186000112

Mobile phase:

860 mL water, 20 mL methanesulfonic acid sloution, 20 mL diethylamine solution, 100 mL acetonitrile; pH adjusted to 2.6 with diethylamine solution

Diethylamine solution: 10 mL diethylamine in 100 mL water

Methanesulfonic acid solution: 14 mL methanesulfonic acid and 8 mL glacial acetic acid in 200 mL water

Flow rate:

1.0 mL/min

Injection volume:

50 μL

Detection:

UV @ 235 nm

USP Tailing Factor

  1. 1.76 
  2. 1.33 

Results and Discussion

Featured Products

WA31763.141, June 2003

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