The diversity of chemical composition and natural abundance levels in a biological system’s complete set of metabolites challenge chromatographic and mass spectrometric performance. Waters LC-MS-based workflows for discovery metabolomics deliver the flexibility to analyze metabolites of significance in your sample in a reproducible, unbiased manner with powerful performance. Generate your hypothesis faster with:
Case Study: Metabolic Profiling at the National Phenome Centre
Achieve exceptional science 100% of the time with the Xevo MRT Mass Spectrometer. This state-of-the-art QTof delivers 100K FWHM resolution at 100 Hz with sub-ppm mass accuracy for confident identification and greater productivity in your lab.
Minimize metal-sensitive analyte loss and improve metabolite recovery with the ACQUITY Premier System for a step change in chromatographic performance, lab efficiency, and risk control.
Combine novel cyclic ion mobility separation with state-of-the-art high performance, time-of-flight mass spectrometry with SELECT SERIES Cyclic IMS to extend the benefits of routine ion mobility and achieve variable, high-resolution separations.
Accelerate your research and comprehensively identify analytes in your complex samples with the SELECT SERIES MRT, built with state-of-the-art Multi Reflecting Time-of-Flight (MRT) technology.
Obtain ultimate flexibility to support scientific creativity and technical success for discovery metabolomics applications with SYNAPT XS, for cutting-edge analytical performance with SONAR and HDMSE to interrogate complex mixtures.
Three-dimensional drift time plot highlighting two features separated by a single pass with the SELECT SERIES Cyclic ion mobility with each feature’s corresponding high energy fragmentation spectra. Selected features in the three-dimensional plots are outlined in the dark blue box.
Representative chromatograms from the aqueous and organic phases following the MTBE extraction of human sputum.
A representative triglyceride lipid at m/z 874 is provided at scan rates of 1, 5, 10 and 20 Hz, for which we can see that the mass resolution is maintained across all scan rates in the region of 80,000.
