• Application Note

Acids Scale-Up: Formic Acid

Acids Scale-Up: Formic Acid
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates SunFire analytical to prep scale-up of acidic active pharmaceutical compounds in formic acid.

Introduction

The compounds used in this study are - 

  1. Althiazide (25 mg/mL )
  2. Bendroflumethiazide (25 mg/mL)
  3. Amcinonide (20 mg/mL)

Experimental

Conditions

Column:

SunFire C8 4.6 x 50 mm, 5 μm

SunFire C8 19 x 50 mm, 5 μm

Part number:

186002735

186002751

Mobile phase A:

Water with 0.1% FA

Mobile phase B:

ACN with 0.1% FA

Temperature:

Ambient

Detection:

UV @ 270 nm

Instrument:

AutoPurification Systems

Results and Discussion

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WA41882, May 2005

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