Veterinary drugs play an important role in the production and welfare of livestock and poultry. Incorrect use or the shortening of the withdrawal time after treatment can possibly lead to the presence of residues in animal tissues and related foodstuffs. Most countries have regulatory approval systems in place which establish which veterinary drug treatments are permitted and set Maximum Residue Limits (MRLs). The use of non-approved medicines is prohibited.
Waters solutions help support food laboratories in efficiently screening or confirming samples, ensuring consumer safety, and facilitating trade through checking regulatory compliance.
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LC-MS/MS is a powerful alternative for screening animal tissues and associated foodstuffs for veterinary drug residues. The Xevo TQ Absolute provides excellent sensitivity and selectivity, enabling both the screening and confirmation of wide range of veterinary drug residues at concentrations typically well below MRLs.
Achieve superior performance per square inch and exceptional analytical flexibility with the Xevo TQ-S micro, ideal for high-quality data, injection after injection, while maximizing laboratory efficiency with a small footprint.
Maximize the sensitivity, repeatability, and robustness of your LC and LC-MS veterinary drug residue applications with the ACQUITY Premier System, which features MaxPeak High Performance Surfaces (HPS) Technology for improvements in separation and detection of metal-sensitive analytes.
The Waters ACQUITY UPLC I-Class PLUS System coupled to the Xevo TQ-S micro enables a fast, reliable and accurate solution for the determination of veterinary drug residues using either class-specific or multi-residue approaches.
Effects of mobile phase aqueous content on the retention times of selected aminoglycosides (AMGs) on an Atlantis Premier BEH Z-HILIC Column.
A selection of chromatograms from analysis of a matrix-matched standard in bovine muscle extract at 10 µg/kg showing retention of some polar compounds and separation of isobaric compounds.
Chromatogram of a matrix-matched standard at the different MRLs showing all 18 macrolide antibiotics.
Overlaid chromatograms showing the effect of HPS on known metal sensitive compounds. HPS – (red) and stainless steel (green) for (a) Tetracycline (ESI+, 445.45 > 410.00), (b) Chlortetracycline (ESI+, 479.30 > 444.18), and (c) Oxytetracycline (ESI+, 461.26 > 426.13).
