Forensic Toxicology

Forensic Toxicology

Get the sensitivity, reproducibility, and ease-of-use necessary to perform targeted and non-targeted screening and confirmatory techniques on complex biological samples with Waters forensic toxicology solutions. With Waters, you can confidently identify both expected and unexpected compounds in your routine forensic testing, confirmation, and quantitation workflows.

Get the sensitivity, reproducibility, and ease-of-use necessary to perform targeted and non-targeted screening and confirmatory techniques on complex biological samples with Waters forensic toxicology solutions. With Waters, you can confidently identify both expected and unexpected compounds in your routine forensic testing, confirmation, and quantitation workflows.

Blood sample tubes from blood donation for analysis
Blood sample tubes from blood donation for analysis

Overview

Whether you’re challenged to present reliable and secure forensic sample analysis data, detect prohibited substances, or identify illicit or prescription drugs, Waters can provide you with powerful solutions for both targeted and non-targeted screening and confirmation workflows for your routine forensic toxicology laboratory.

With ACQUITY UPLC I-Class PLUS System, Xevo TQ-S micro, and Xevo TQ Absolute, Waters can provide high-throughput confirmation, sensitivity, and accuracy across a wide range of biological matrices. With the combination of the ACQUITY UPLC I-Class PLUS System, Xevo G3 QTof, waters_connect Software Solutions, Targeted MRM screening with Xevo TQ-S micro, non-targeted screening with Xevo TQD and Xevo TQ-S micro, Waters forensic toxicology solutions bring the power and versatility of high-resolution mass spectrometry and accurate mass to your routine forensic toxicology laboratory.

With Waters, you can easily streamline your workflow and improve confidence in data accuracy for even the most challenging cases.


For forensic toxicology use only.

Applications

Easily identifying and quantifying compounds is critical, and retention time, precursor, and fragment ion accurate mass are all used to identify compounds. Learn how you can seamlessly add new compounds to meet evolving needs with these application notes.

Easily identifying and quantifying compounds is critical, and retention time, precursor, and fragment ion accurate mass are all used to identify compounds. Learn how you can seamlessly add new compounds to meet evolving needs with these application notes.


Genetic engineer working in laboratory


Application Notebook: Forensic Toxicology

Clinical laboratories around the world are focused on reporting quality and truth. Accurate test results are necessary for clinical research and discovery, as well as routine diagnostic testing. Whether your lab is in search of a novel biomarker, identifying the latest designer drug or looking to take a routine lab test to a new level of performance, see how Waters can help you make a difference.

Clinical laboratories around the world are focused on reporting quality and truth. Accurate test results are necessary for clinical research and discovery, as well as routine diagnostic testing. Whether your lab is in search of a novel biomarker, identifying the latest designer drug or looking to take a routine lab test to a new level of performance, see how Waters can help you make a difference.


Female chemist looking at white pill, new medication testing in laboratory

Solutions



Address the constantly evolving challenges faced by forensic toxicology labs with our powerful solutions for targeted and non-targeted screening workflows.

Complex chromatography challenges, solved

Complex chromatography challenges, solved

Get narrow, ultra-efficient peaks, enhancing the sensitivity of any mass spectrometer and simplifying the characterization of your most complex samples across targeted and non-targeted screening workflows using ACQUITY UPLC I-Class PLUS System.

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

Complete coverage for confident characterization

Complete coverage for confident characterization

Maximize sample information for your analytes from detailed characterization to accurate quantitation with the Xevo G3 QTof, which enables complete confidence in your results.

  • Non-Targeted Screening Workflow

Delivering performance and speed without compromise

Delivering performance and speed without compromise

Achieve exceptional results for toxicology screening 100% of the time with the Xevo MRT Mass Spectrometer. This state-of-the-art QTof delivers 100K FWHM resolution at 100 Hz with sub-ppm mass accuracy for confident identification and greater productivity in your forensic lab.

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

High performance from a compact design with rapid, reliable and reproducible quantitative data

High performance from a compact design with rapid, reliable and reproducible quantitative data

Achieve fast-scanning, high-sensitivity, ease of use and robustness for your routine forensic analysis with the Xevo TQ-S micro.

  • Non-Targeted Screening Workflow

Press on to bring the power of mass detection to your lab

Press on to bring the power of mass detection to your lab

Minimize the risk of unexpected coelutions, or components and confirm trace components with certainty using ACQUITY QDa Mass Detector. Enhance the analytical value and productivity of each analysis.

  • Non-Targeted Screening Workflow


The data speaks for itself

The data speaks for itself
This chromatogram shows compounds (inverted peaks in blue) that have been identified using the UNIFI Toxicology This chromatogram shows compounds (inverted peaks in blue) that have been identified using the UNIFI Toxicology Scientific Library of over 1,000 compounds. A peak eluting at 5.11 minutes did not match any compounds in the library, however, this peak can be automatically further investigated using the powerful discovery tool workflows in UNIFI.
Chromatography of THC-OH, THC-COOH and THC from an extracted urine sample on the ACQUITY UPLC BEH C18 column Chromatography of THC-OH, THC-COOH and THC from an extracted urine sample on the ACQUITY UPLC BEH C18 column, 1.8 μm; 2.1 x 50 mm. The concentrations are 4 ng/mL for all compounds
Chromatogram showing benzimidazoles spiked into pooled blank urine detected by the Xevo TQ-S micro Chromatogram showing benzimidazoles spiked into pooled blank urine detected by the Xevo TQ-S micro using the supplied targeted MRM method. The quantifier ion transition is displayed. 
Recovery of opioid compounds from oral fluid extracted using Oasis MCX Recovery of opioid compounds from oral fluid extracted using Oasis MCX µElution Plates. Error bars indicate standard deviations (N=4).

Webinars and Resources



  • Infographic

General Unknown Screening for Toxicants in Biological Samples

General Unknown Screening for Toxicants in Biological Samples
  • eBook

Comprehensive Drug Screening for Forensic Toxicology

Comprehensive Drug Screening for Forensic Toxicology
  • Case Study

Delivering an Open-Access Drug Early Warning System for Novel Psychoactive Substances Case Study

Delivering an Open-Access Drug Early Warning System for Novel Psychoactive Substances Case Study
  • Case Study

LC-MS Innovations Facilitate Pioneering Testing Capabilities in Forensic and Clinical Toxicology

LC-MS Innovations Facilitate Pioneering Testing Capabilities in Forensic and Clinical Toxicology
  • White Paper

Quality Over Quantity – It’s Not Always a Numbers Game

Quality Over Quantity – It’s Not Always a Numbers Game
  • On Demand Webinar

Quality Over Quantity – It’s Not Always a Numbers Game

Quality Over Quantity – It’s Not Always a Numbers Game
  • Brochure

Update to HRMS QTof Toxicology Library

Update to HRMS QTof Toxicology Library

Related

Waters unlocks the potential of science providing our customers with innovative clinical diagnostic solutions and scientific knowledge in areas that will enhance the lives of patients around the world.

Learn more about Forensic Toxicology Solutions.

Learn more about Forensic Toxicology Solutions.

Blood sample tubes from blood donation for analysis