Forensic Toxicology

Forensic Toxicology

Get the sensitivity, reproducibility, and ease-of-use necessary to perform targeted and non-targeted screening and confirmatory techniques on complex biological samples with Waters forensic toxicology solutions. With Waters, you can confidently identify both expected and unexpected compounds in your routine forensic testing, confirmation, and quantitation workflows.

Get the sensitivity, reproducibility, and ease-of-use necessary to perform targeted and non-targeted screening and confirmatory techniques on complex biological samples with Waters forensic toxicology solutions. With Waters, you can confidently identify both expected and unexpected compounds in your routine forensic testing, confirmation, and quantitation workflows.
Blood sample tubes from blood donation for analysis
Blood sample tubes from blood donation for analysis

Overview

Whether you’re challenged to present reliable and secure forensic sample analysis data, detect prohibited substances, or identify illicit or prescription drugs, Waters can provide you with powerful solutions for both targeted and non-targeted screening and confirmation workflows for your routine forensic toxicology laboratory.

With ACQUITY UPLC I-Class PLUS System, Xevo TQ-S micro, and Xevo TQ Absolute, Waters can provide high-throughput confirmation, sensitivity, and accuracy across a wide range of biological matrices. With the combination of the ACQUITY UPLC I-Class PLUS System, Xevo G3 QTof, waters_connect Software Solutions, Targeted MRM screening with Xevo TQ-S micro, non-targeted screening with Xevo TQD and Xevo TQ-S micro, Waters forensic toxicology solutions bring the power and versatility of high-resolution mass spectrometry and accurate mass to your routine forensic toxicology laboratory.

With Waters, you can easily streamline your workflow and improve confidence in data accuracy for even the most challenging cases.

For forensic toxicology use only.

Applications

Easily identifying and quantifying compounds is critical, and retention time, precursor, and fragment ion accurate mass are all used to identify compounds. Learn how you can seamlessly add new compounds to meet evolving needs with these application notes.

Easily identifying and quantifying compounds is critical, and retention time, precursor, and fragment ion accurate mass are all used to identify compounds. Learn how you can seamlessly add new compounds to meet evolving needs with these application notes.

Application Notes

Automatically search for characteristic fragments and utilize "in-silico fragmentation" information to detect and identify new emerging psychoactive substances with UNIFI. Learn how Waters robust tools can streamline identification, efficiently address unidentified compounds, save valuable time and employ comprehensive analysis methods with fragment ion data with these application notes.

Automatically search for characteristic fragments and utilize "in-silico fragmentation" information to detect and identify new emerging psychoactive substances with UNIFI. Learn how Waters robust tools can streamline identification, efficiently address unidentified compounds, save valuable time and employ comprehensive analysis methods with fragment ion data with these application notes.

Application Notes

Application Notebook: Forensic Toxicology

Clinical laboratories around the world are focused on reporting quality and truth. Accurate test results are necessary for clinical research and discovery, as well as routine diagnostic testing. Whether your lab is in search of a novel biomarker, identifying the latest designer drug or looking to take a routine lab test to a new level of performance, see how Waters can help you make a difference.

Clinical laboratories around the world are focused on reporting quality and truth. Accurate test results are necessary for clinical research and discovery, as well as routine diagnostic testing. Whether your lab is in search of a novel biomarker, identifying the latest designer drug or looking to take a routine lab test to a new level of performance, see how Waters can help you make a difference.
Download the Application Notebook
Female chemist looking at white pill, new medication testing in laboratory

Solutions

Address the constantly evolving challenges faced by forensic toxicology labs with our powerful solutions for targeted and non-targeted screening workflows.

Complex chromatography challenges, solved

Complex chromatography challenges, solved
ACQUITY UPLC I-Class PLUS System

Get narrow, ultra-efficient peaks, enhancing the sensitivity of any mass spectrometer and simplifying the characterization of your most complex samples across targeted and non-targeted screening workflows using ACQUITY UPLC I-Class PLUS System.

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

Complete coverage for confident characterization

Complete coverage for confident characterization
Xevo G3 QTof

Maximize sample information for your analytes from detailed characterization to accurate quantitation with the Xevo G3 QTof, which enables complete confidence in your results.

  • Non-Targeted Screening Workflow

Delivering performance and speed without compromise

Delivering performance and speed without compromise
Xevo MRT Mass Spectrometer

Achieve exceptional results for toxicology screening 100% of the time with the Xevo MRT Mass Spectrometer. This state-of-the-art QTof delivers 100K FWHM resolution at 100 Hz with sub-ppm mass accuracy for confident identification and greater productivity in your forensic lab.

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

High performance from a compact design with rapid, reliable and reproducible quantitative data

High performance from a compact design with rapid, reliable and reproducible quantitative data
Xevo TQ-S micro Triple Quadrupole Mass Spectrometry

Achieve fast-scanning, high-sensitivity, ease of use and robustness for your routine forensic analysis with the Xevo TQ-S micro.

  • Non-Targeted Screening Workflow

Press on to bring the power of mass detection to your lab

Press on to bring the power of mass detection to your lab
ACQUITY QDa II Mass Detector

Minimize the risk of unexpected coelutions, or components and confirm trace components with certainty using ACQUITY QDa Mass Detector. Enhance the analytical value and productivity of each analysis.

  • Non-Targeted Screening Workflow

Extend your quantitative capabilities within forensic toxicology to definitively identify illicit drugs and other toxicants of interest with our powerful solutions for confirmation and quantitation workflows.

Complex chromatography challenges, solved

Complex chromatography challenges, solved
ACQUITY UPLC I-Class PLUS System

Get narrow, ultra-efficient peaks, enhancing the sensitivity of any mass spectrometer and simplifying the characterization of your most complex samples across confirmation and quantitation workflows using ACQUITY UPLC I-Class PLUS System.

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

Absolute power to easily quantitate your most challenging toxicology compounds

Absolute power to easily quantitate your most challenging toxicology compounds
Xevo TQ Absolute

Achieve and maintain high performance and productivity with significantly increased sensitivity for negative ionizing compounds with our compact, sustainable tandem quadrupole mass spectrometer, ideal for confirmation and, quantitation analyses.

  • Targeted Screening Workflow

High performance from a compact design with rapid, reliable and reproducible quantitative data

High performance from a compact design with rapid, reliable and reproducible quantitative data
Xevo TQ-S micro Triple Quadrupole Mass Spectrometry

Achieve fast-scanning, high-sensitivity, ease of use and robustness for your quantitative forensic analysis with the Xevo TQ-S micro.

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

Ensure your forensic laboratory runs efficiently with Waters advanced software that provides quality and reliable results for increased productivity.

Delivering connected science for your lab evolution

Delivering connected science for your lab evolution
waters_connect Software Solutions

waters_connect lab informatics software is a single platform for LC and LC-MS applications to streamline your workflows, improve usability and compliance, and accelerate scientific and business outcomes.

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

Transform data into usable results

Transform data into usable results
MassLynx Mass Spectrometry Software

Acquire, analyze, manage, and share your nominal and exact mass, MS and MS/MS data with MassLynx Software for Waters mass spectrometry (MS) systems. 

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

Streamline quantitative data, processing and reporting

Streamline quantitative data, processing and reporting
TargetLynx Application Manager

Automate your data acquisition, processing and reporting, incorporating a wide range of confirmatory checks for providing confidence in quantitative results with Waters TargetLynx Software.

  • Targeted Screening Workflow

Easily automate the LC-MS data

Easily automate the LC-MS data
Waters ChromaLynx XS Software

Streamline the identification of compounds in complex mixtures by utilizing automated chromatographic peak detection, mass spectral deconvolution, library searching, accurate mass measurements, and rigorous sample comparison algorithms with Waters ChromaLynx XS Software.

  • Non-Targeted Screening Workflow

Our reliable and robust columns and consumables can be easily integrated into your forensic toxicology screening, confirmation, and quantitation workflows.

Faster, cleaner, and simpler sample preparation starts here

Faster, cleaner, and simpler sample preparation starts here
Oasis Sample Extraction Products 

Meet your sample preparation needs, from simple matrix clean-up to more complex sample preparation challenges with Waters Oasis Solid-Phase Sample Extraction Products. Get unmatched purity, consistency, and quality for all your sample analysis.

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

Increase speed, sensitivity, and resolution, without compromising data integrity 

Increase speed, sensitivity, and resolution, without compromising data integrity 
ACQUITY UPLC Columns 

Improve sample throughput, achieve unmatched resolution, and enhance analyte sensitivity with Waters ACQUITY UPLC Columns and substantially reduce your analysis time and cost-per-sample.

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

Achieve accurate results for several forensic screening, confirmation, and quantitation workflows using streamlined Waters analytical services.

Your success is just a click away

Your success is just a click away
Waters Global Services

Optimize your laboratory’s productivity while addressing your budget realities with Waters Global Services. Maintain peak system performance, minimize down time, address scientific application challenges, and support stringent compliance requirements.

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

Make science more accessible with Waters Capital 

Make science more accessible with Waters Capital 
Payment Solutions

Maximize your lab resources and minimize risk with payment options from Waters Capital, which includes innovative solutions to upgrade aging instruments, customized support, and flexible options to bundle your complete laboratory solution in one easy monthly payment – everything you need to advance your science. 

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

Modern educational platform for clinical and forensic customers

Modern educational platform for clinical and forensic customers
Waters Academy - Clinical

Increase your analytical capabilities to provide better care with Waters Academy-Clinical, the modern onboarding, training and education platform for clinical and forensic laboratories using Waters LC-MS/MS system solutions.

  • Non-Targeted Screening Workflow
  • Targeted Screening Workflow

The data speaks for itself

The data speaks for itself
This chromatogram shows compounds (inverted peaks in blue) that have been identified using the UNIFI Toxicology Scientific Library of over 1,000 compounds. A peak eluting at 5.11 minutes did not match any compounds in the library, however, this peak can be automatically further investigated using the powerful discovery tool workflows in UNIFI.
Chromatography of THC-OH, THC-COOH and THC from an extracted urine sample on the ACQUITY UPLC BEH C18 column, 1.8 μm; 2.1 x 50 mm. The concentrations are 4 ng/mL for all compounds
Chromatogram showing benzimidazoles spiked into pooled blank urine detected by the Xevo TQ-S micro using the supplied targeted MRM method. The quantifier ion transition is displayed. 
Recovery of opioid compounds from oral fluid extracted using Oasis MCX µElution Plates. Error bars indicate standard deviations (N=4).

Webinars and Resources

  • Infographic

General Unknown Screening for Toxicants in Biological Samples

General Unknown Screening for Toxicants in Biological Samples
Download
  • eBook

Comprehensive Drug Screening for Forensic Toxicology

Comprehensive Drug Screening for Forensic Toxicology
Download
  • Case Study

Delivering an Open-Access Drug Early Warning System for Novel Psychoactive Substances Case Study

Delivering an Open-Access Drug Early Warning System for Novel Psychoactive Substances Case Study
Download
  • Case Study

LC-MS Innovations Facilitate Pioneering Testing Capabilities in Forensic and Clinical Toxicology

LC-MS Innovations Facilitate Pioneering Testing Capabilities in Forensic and Clinical Toxicology
Download
  • White Paper

Quality Over Quantity – It’s Not Always a Numbers Game

Quality Over Quantity – It’s Not Always a Numbers Game
Download
  • On Demand Webinar

Quality Over Quantity – It’s Not Always a Numbers Game

Quality Over Quantity – It’s Not Always a Numbers Game
Download
  • Brochure

Update to HRMS QTof Toxicology Library

Update to HRMS QTof Toxicology Library
Download
  • Brochure

HRMS Forensic Toxicology Screening Brochure

HRMS Forensic Toxicology Screening Brochure
Download

Related

Clinical Research and Diagnostics
Waters unlocks the potential of science providing our customers with innovative clinical diagnostic solutions and scientific knowledge in areas that will enhance the lives of patients around the world.

Learn more about Forensic Toxicology Solutions.

Learn more about Forensic Toxicology Solutions.
Blood sample tubes from blood donation for analysis
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