Sample Preparation

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Meet your lab’s specific needs and desired level of sensitivity and throughput with Waters innovative sample preparation solutions. Speed up and simplify sample matrix cleanup, increase sample concentration with better sensitivity, and meet any other sample preparation challenges with Waters comprehensive, varied solution portfolio, built on years of practical analytical experience.

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Explore a cultivated list of knowledge

Solid-Phase Extraction
Phospholipid Removal
Protein Precipitation

The Latest in Solid-Phase Extraction

Development of an LC–MS/MS assay for quantification of intact INSL3 in rat plasma
— Nicole A Schneck; Lela Mortezavi; Alan R Olzinski, Diane Posavec; Larry J Jolivette, Timothy W Sikorski; Shan-Shan Zhang; Christine G Schnackenberg; Hermes Licea-Perez. Bioanlaysis.
DOI: 10.4155/bio-2023-0120.

Optimisation of Solid-Phase Extraction and LC-MS/MS Analysis of Six Breast Cancer Drugs in Patient Plasma Samples
— Lu Turković; Dragana Mutavdžić Pavlović; Zvonimir Mlinarić; Anamarija Skenderović; Tajana Silovski Miranda Sertić. Journal of Chromatographic Science.
DOI: 10.1093/chromsci/bmac064.

Comparison of Reversed-Phase and Mixed-Mode SPE for Enrichment and Clean-Up of Surrogate Peptides in CysC Quantified by LC–MS/MS
— Zijie Tang; Huoyan Ji. Journal of Chromatographic Science.
DOI: 10.1093/chromsci/bmac064.

Development and Validation of an HILIC/MS/MS Method for Determination of Nusinersen in Rabbit Plasma
— Zhang, X.; Sha, C.; Zhang, W.; Zhao, F.; Zhu, M.; Leng, G.; Liu, W. Heliyon 2024, 10(10), e31213.
DOI: 10.1016/j.heliyon.2024.e31213.

Innovative Solid-Phase Extraction Strategies for Improving the Advanced Chromatographic Determination of Drugs in Challenging Biological Samples
— Mahdavijalal, M.; Petio, C.; Staffilano, G.; Mandrioli, R.; Protti, M. Biological Samples. Molecules 2024, 29(10), 2278.
DOI: 10.3390/molecules29102278.

Optimizing Solid Phase Extraction and HPLC-MS/MS Parameters for Reliable Quantification of COVID-19 Pharmaceuticals in Mexico City’s Wastewater: A Design of Experiments Approach
— Cortés-Lagunes, R. S.; Garduño-Jiménez, A.-L.; Romero-Solano, A.; Zanella, R.; Prado, B.; Zamora, O.; Durán-Álvarez, J. C. Microchem. J. 2024, 190, e108936.
DOI: 10.1016/j.microc.2024.108936.

Oasis PRiME MCX SPE Plates & Cartridges | Oasis Sample Extraction Products

The Latest in Phospholipid Removal

Development and validation of a simple, selective, and sensitive LC-MS/MS assay for the quantification of remdesivir in human plasma
— Ryan Nguyen; Jennifer C. Goodell; Priya S.Shankarappa; Sara Zimmerman; Tyler Yin; Cody J. Peer; William D. Figg. Journal of Chromatography B.
DOI: 10.1016/j.jchromb.2021.122641.

Simultaneous determination of fluoxetine, venlafaxine, vortioxetine and their active metabolites in human plasma by LC–MS/MS using one-step sample preparation procedure
— Martin Kertys; Michaela Krivosova; Igor Ondrejka; Igor Hrtanek; Ingrid Tonhajzerova. Journal of Pharmaceutical and Biomedical Analysis.
DOI: 10.1016/j.jpba.2020.113098.

Integrative phosphatidylcholine metabolism through phospholipase A2 in rats with chronic kidney disease
— Yan-ni Wang; Zhi-hao Zhang; Hong-jiao Liu; Zhi-yuan Guo; Liang Zou; Ya-mei Zhang; Ying-yong Zhao. Acta Pharmacologica Sinica, 44, 393–405 (2023).

Associations of Cord Plasma Per- and Polyfluoroalkyl Substances (PFAS) with Neonatal and Child Body Composition and Adiposity: The GUSTO Study
— Chen, L.-W.; Ng, S.; Tint, M.-T.; Michael, N.; Sadananthan, S. A.; Ong, Y. Y.; Yuan, W. L.; Chen, Z.-Y.; Chen, C.-Y.; Godfrey, K. M.; Tan, K. H.; Gluckman, P. D.; Chong, Y.-S.; Eriksson, J. G.; Yap, F.; Lee, Y. S.; Fortier, M. V.; Velan, S. S.; Chan. Environ. Int. 2024.
DOI: 10.1016/j.envint.2024.112936.

Quantitative Determination of R/S-Methadone in Human Serum Using Ultra-High Performance Supercritical Fluid Chromatography-Tandem Mass Spectrometry: A Method for Routine Use
— Hansen, M.; Havnen, H.; Andreassen, T. N.; Spigset, O.; Hegstad, S. Drug Test. Anal. 2024.
DOI: 10.1002/dta.3693

Moxidectin is a candidate for use as an in vivo internal standard in pharmacokinetic studies, as demonstrated with use in simultaneous tissue cage and ultrafiltration fluid collection
— Munn, R.; Whittem, T. Front. Vet. Sci. 2024, 11.
DOI: 10.3389/fvets.2024.1332974.

The Latest in Protein Precipitation

Topical Wound Treatment with a Nitric Oxide-Releasing PDE5 Inhibitor Formulation Enhances Blood Perfusion and Promotes Healing in Mice
— Maya Ben-Yehuda Greenwald; Yu-Hang Liu; Weiye Li;Paul Hiebert; Maria Zubair; Hermann Tenor; Tobias Braun; Reto Naef; Daniel Razansky; Sabine Werner. Pharmaceutics 2022, 14(11), 2358.
DOI: 10.3390/pharmaceutics14112358.

Sample preparation strategies for mass spectrometry analysis in human exposome research: Current status and future perspectives
— Yunyun Gu; Jesse T. Peach; Benedikt Warth. TrAC Trends in Analytical Chemistry.
DOI: 10.1016/j.trac.2023.117151.

Pharmacodynamics of Tebipenem: New Options for Oral Treatment of Multidrug-Resistant Gram-Negative Infections
— Laura McEntee; Adam Johnson; Nicola Farrington; Jennifer Unsworth; Aaron Dane; Akash Jain; Nicole Cotroneo; Ian Critchley; David Melnick; Thomas Parr; Paul G. Ambrose; Shampa Das; William Hope. ASM Journals.
DOI: 10.1128/aac.00603-19.

Targeted and untargeted metabolomic profiles in wild rabbit does (Oryctolagus cuniculus) of different breeding states (pregnant and lactating)
— Marín-García, P. J.; Rouco, C.; Llobat, L.; Larsen, T.; Hedemann, M. S. J. Exp. Zool. A 2024.
DOI: 10.1002/jez.2818

Preclinical Testing of Chronic ICA-1S Exposure: A Potent Protein Kinase C-ι Inhibitor as a Potential Carcinoma Therapeutic
— Apostolatos, C. A.; Ratnayake, W. S.; Breedy, S.; Chuah, J. K. C.; Miller, J. A.; Zink, D.; Bourgeois, M.; Acevedo-Duncan, M. Drugs Drug Candidates 2024, 3(2), 368–379.
DOI: 10.3390/ddc3020022.

Role of Glucose Metabolism Reprogramming in Keratinocytes in the Link between Psoriasis and Metabolic Syndrome
—Yan, L.; Wang, W.; Qiu, Y.; Yu, C.; Wang, R.; Li, C. Int. Immunopharmacol. 2024, 112, 112704.
DOI: 10.1016/j.intimp.2024.112704.