樣品前處理

樣品前處理

更快、更純淨也更簡單的樣品前處理作業,從這裡開始。

更快、更純淨也更簡單的樣品前處理作業,從這裡開始。

簡化樣品前處理流程, 開發穩固的方法。

Waters創新的樣品前處理解決方案能滿足實驗室的特定需求,達到理想的靈敏度和通量。Waters擁有多年的實際分析經驗,提供全方位、多樣化的解決方案產品組合,加速並簡化樣品基質淨化作業、提高樣品濃度且靈敏度更高,還能解決任何其他樣品前處理難題。


瀏覽詳盡的知識清單

瀏覽詳盡的知識清單

最新的固相萃取技術

最新的固相萃取技術


開發LC-MS/MS化驗方法,用於定量分析大鼠血漿中的完整INSL3 (Development of an LC–MS/MS assay for quantification of intact INSL3 in rat plasma)
— Nicole A Schneck; Lela Mortezavi; Alan R Olzinski, Diane Posavec; Larry J Jolivette, Timothy W Sikorski; Shan-Shan Zhang; Christine G Schnackenberg; Hermes Licea-Perez.Bioanlaysis.
DOI: 10.4155/bio-2023-0120.

患者血漿樣品中六種乳癌藥物的固相萃取和LC-MS/MS分析優化(Optimisation of Solid-Phase Extraction and LC-MS/MS Analysis of Six Breast Cancer Drugs in Patient Plasma Samples)
— Lu Turković; Dragana Mutavdžić Pavlović; Zvonimir Mlinarić; Anamarija Skenderović; Tajana Silovski Miranda Sertić. Journal of Chromatographic Science.
DOI: 10.1093/chromsci/bmac064.

由LC-MS/MS定量CysC中替代胜肽的富集和淨化,比較逆相和混合模式SPE有何不同(Comparison of Reversed-Phase and Mixed-Mode SPE for Enrichment and Clean-Up of Surrogate Peptides in CysC Quantified by LC–MS/MS)
— Zijie Tang; Huoyan Ji. Journal of Chromatographic Science. 
DOI: 10.1093/chromsci/bmac064.

開發並驗證一種用於測定兔子血漿所含諾西那生的HILIC/MS/MS方法(Development and Validation of an HILIC/MS/MS Method for Determination of Nusinersen in Rabbit Plasma) 
— Zhang, X.; Sha, C.; Zhang, W.; Zhao, F.; Zhu, M.; Leng, G.; Liu, W. Heliyon 2024, 10(10), e31213.
DOI: 10.1016/j.heliyon.2024.e31213.

運用新式固相萃取策略改進高難度生物樣品之進階層析分離測定(Innovative Solid-Phase Extraction Strategies for Improving the Advanced Chromatographic Determination of Drugs in Challenging Biological Samples)
— Mahdavijalal, M.; Petio, C.; Staffilano, G.; Mandrioli, R.; Protti, M. Biological Samples.Molecules 2024, 29(10), 2278.
DOI: 10.3390/molecules29102278.

固相萃取與HPLC-MS/MS參數最佳化,用於可靠定量墨西哥城廢水中的COVID-19藥物:實驗方法設計(Optimizing Solid Phase Extraction and HPLC-MS/MS Parameters for Reliable Quantification of COVID-19 Pharmaceuticals in Mexico City’s Wastewater: A Design of Experiments Approach)
— Cortés-Lagunes, R. S.; Garduño-Jiménez, A.-L.; Romero-Solano, A.; Zanella, R.; Prado, B.; Zamora, O.; Durán-Álvarez, J. C. Microchem.J. 2024, 190, e108936.
DOI: 10.1016/j.microc.2024.108936.

最新的磷脂去除技術

最新的磷脂去除技術


開發並驗證一種簡單、選擇性高且靈敏度高的LC-MS/MS化驗方法,用於定量人血漿中的瑞德西韋(Development and validation of a simple, selective, and sensitive LC-MS/MS assay for the quantification of remdesivir in human plasma)
— Ryan Nguyen; Jennifer C. Goodell; Priya S.Shankarappa; Sara Zimmerman; Tyler Yin; Cody J. Peer; William D. Figg.Journal of Chromatography B.
DOI: 10.1016/j.jchromb.2021.122641.

使用一步式樣品前處理程序,以LC-MS/MS方式同時測定人類血漿中的氟西汀(fluoxetine)、文拉法辛(venlafaxine)、沃替西汀(vortioxetine)及其活性代謝物(Simultaneous determination of fluoxetine, venlafaxine, vortioxetine and their active metabolites in human plasma by LC–MS/MS using one-step sample preparation procedure)
— Martin Kertys; Michaela Krivosova; Igor Ondrejka; Igor Hrtanek; Ingrid Tonhajzerova. Journal of Pharmaceutical and Biomedical Analysis.
DOI: 10.1016/j.jpba.2020.113098.

慢性腎髒病大鼠透過磷脂酶A2評估磷脂醯膽鹼的綜合代謝(Integrative phosphatidylcholine metabolism through phospholipase A2 in rats with chronic kidney disease)
— Yan-ni Wang; Zhi-hao Zhang; Hong-jiao Liu; Zhi-yuan Guo; Liang Zou; Ya-mei Zhang; Ying-yong Zhao. Acta Pharmacologica Sinica, 44, 393–405 (2023).

臍帶血漿中全氟與多氟烷基物質(PFAS)與新生兒及兒童身體組成和肥胖症之關聯性:GUSTO研究(Associations of Cord Plasma Per- and Polyfluoroalkyl Substances (PFAS) with Neonatal and Child Body Composition and Adiposity: The GUSTO Study)
— Chen, L.-W.; Ng, S.; Tint, M.-T.; Michael, N.; Sadananthan, S. A.; Ong, Y. Y.; Yuan, W. L.; Chen, Z.-Y.; Chen, C.-Y.; Godfrey, K. M.; Tan, K. H.; Gluckman, P. D.; Chong, Y.-S.; Eriksson, J. G.; Yap, F.; Lee, Y. S.; Fortier, M. V.; Velan, S. S.; Chan. Environ. Int. 2024.
DOI: 10.1016/j.envint.2024.112936.

使用超高效超臨界流體層析系統─串聯式質譜分析定量測定人類血漿中的R/S-美沙冬:一種例行用途的方法(Quantitative Determination of R/S-Methadone in Human Serum Using Ultra-High Performance Supercritical Fluid Chromatography-Tandem Mass Spectrometry: A Method for Routine Use)
— Hansen, M.; Havnen, H.; Andreassen, T. N.; Spigset, O.; Hegstad, S. Drug Test.Anal. 2024.
DOI: 10.1002/dta.3693

莫昔克汀在藥物動力學研究中是適合發揮體內內標準品用途的候選藥物,其可同時應用於組織囊籠與超濾液收集就足以證明(Moxidectin is a candidate for use as an in vivo internal standard in pharmacokinetic studies, as demonstrated with use in simultaneous tissue cage and ultrafiltration fluid collection)
— Munn, R.; Whittem, T. Front.Vet.Sci. 2024, 11.
DOI: 10.3389/fvets.2024.1332974.

最新的蛋白質沉澱技術

最新的蛋白質沉澱技術


使用能釋放一氧化氮的PDE5抑製劑配方,局部治療小鼠創面,能增強血液灌流並促進癒合(Topical Wound Treatment with a Nitric Oxide-Releasing PDE5 Inhibitor Formulation Enhances Blood Perfusion and Promotes Healing in Mice)
— Maya Ben-Yehuda Greenwald; Yu-Hang Liu; Weiye Li;Paul Hiebert; Maria Zubair; Hermann Tenor; Tobias Braun; Reto Naef; Daniel Razansky; Sabine Werner. Pharmaceutics 2022, 14(11), 2358.
DOI: 10.3390/pharmaceutics14112358.

人類暴露體研究中,質譜分析的樣品前處理策略:現狀與未來展望(Sample preparation strategies for mass spectrometry analysis in human exposome research: Current status and future perspectives)
— Yunyun Gu; Jesse T. Peach; Benedikt Warth. TrAC Trends in Analytical Chemistry.
DOI: 10.1016/j.trac.2023.117151.

替比培南的藥效動力學:口服治療多重抗藥性革蘭氏陰性菌感染的新選擇(Pharmacodynamics of Tebipenem: New Options for Oral Treatment of Multidrug-Resistant Gram-Negative Infections)
— Laura McEntee; Adam Johnson; Nicola Farrington; Jennifer Unsworth; Aaron Dane; Akash Jain; Nicole Cotroneo; Ian Critchley; David Melnick; Thomas Parr; Paul G. Ambrose; Shampa Das; William Hope. ASM Journals.
DOI: 10.1128/aac.00603-19.

野生雌兔(穴兔,Oryctolagus cuniculus)在不同繁殖狀態(懷孕和哺乳)下的標靶與非標靶代謝體學分析(Targeted and untargeted metabolomic profiles in wild rabbit does (Oryctolagus cuniculus) of different breeding states (pregnant and lactating))
— Marín-García, P. J.; Rouco, C.; Llobat, L.; Larsen, T.; Hedemann, M. S. J. Exp.Zool.A 2024.
DOI: 10.1002/jez.2818

ICA-1S慢性暴露之臨床前試驗:可望應用於上皮癌治療之強效蛋白質激酶C-ι抑制劑(Preclinical Testing of Chronic ICA-1S Exposure: A Potent Protein Kinase C-ι Inhibitor as a Potential Carcinoma Therapeutic)
— Apostolatos, C. A.; Ratnayake, W. S.; Breedy, S.; Chuah, J. K. C.; Miller, J. A.; Zink, D.; Bourgeois, M.; Acevedo-Duncan, M. Drugs Drug Candidates 2024, 3(2), 368–379.
DOI: 10.3390/ddc3020022.

角質細胞中血糖代謝重新編程在乾癬與代謝症候群間連結所發揮之作用(Role of Glucose Metabolism Reprogramming in Keratinocytes in the Link between Psoriasis and Metabolic Syndrome)
—Yan, L.; Wang, W.; Qiu, Y.; Yu, C.; Wang, R.; Li, C. Int.Immunopharmacol. 2024, 112, 112704.
DOI: 10.1016/j.intimp.2024.112704.



善用經過實證的解決方案發揮強大成效

善用經過實證的解決方案發揮強大成效

  • 簡單快速的樣品基質淨化
  • 去除超過95%的基質干擾物質
  • 容易整合到實驗室工作流程
  • 無需活化以及平衡步驟
  • 分析物濃縮與富集
  • 提供7種不同的固相萃取(SPE)充填材料

  • 簡化實驗步驟並提高回收率
  • 提供多種規格和吸附劑
  • 非常適合用於各類GC-MS、HPLC和LC-MS分析樣品
  • 舉世公認最常用的SPE產品

  • 讓蛋白質沉澱孔盤實現高通量分析
  • 專為小量生物樣品而設計
  • 獨特的閥針尖技術,能減少滲漏與串擾問題

  • 去除蛋白質、微粒,以及95%以上的磷脂
  • 提高再現性,獲得更多優質數據
  • 簡易直透式實驗步驟
  • 96孔盤格式能提高通量,並與自動化作業相容


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