• Application Note

Methylphenidate HCL

Methylphenidate HCL
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates the analysis of Methylphenidate HCL using Symmetry Columns.

Introduction

The compound analyzed in this study is Methylphenidate HCL. 

Experimental

HPLC Method

Column:

Symmetry C8, 3.9 x 150 mm, 5 µm

Guard Column:

Symmetry Guard Column 3.9 x 20 mm, 5 µm

Part numbers:

Column - WAT046970, Guard - WAT054250

Mobile phase:

20 mM potassium phosphate, pH 2.18/methanol 80:20

Flow rate:

1.0 mL/min

Injection volume:

15 µL of 200 µg/mL

Detection:

UV @ 254 nm

USP Tailing Factors

  1. 1.5 

Results and Discussion

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WA31763.100, June 2003

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