Preparative Columns

Preparative Columns

Achieve fast, efficient, lab-scale separations for greater throughput with Waters Preparative HPLC Columns, providing predictable performance, and ease of scaling from analytical to prep.

Achieve fast, efficient, lab-scale separations for greater throughput with Waters Preparative HPLC Columns, providing predictable performance, and ease of scaling from analytical to prep.
Acquity columns
Ready to Order?

Address laboratory-scale high-performance liquid chromatography (HPLC) purification challenges with Waters proprietary Optimum Bed Density (OBD) technology in Waters Preparative HPLC Columns. Waters innovative manufacturing procedure combines hardware, particle characteristics, and packed bed densities for columns with excellent stability, reproducibility, loadability, and high efficiencies.

Featured Categories

Featured Categories
MaxPeak Premier Columns
Bioseparation Columns
HPLC Columns
Back To Top Back To Top

Preparative Columns FAQs

1. What materials are used in Waters preparative columns?
Waters preparative columns are typically constructed using high-quality stainless steel for durability and resistance to high pressures. The stationary phases within the columns are made of premium silica-based or polymeric materials, designed for optimal separation performance. These stationary phases are often modified with specific chemistries, such as C18 or C8, to suit various applications. The materials are carefully chosen to ensure chemical compatibility, reproducibility, and long-term stability, even under demanding preparative chromatography conditions.

2. What applications are preparative columns best suited for?
Waters preparative columns are ideal for applications requiring the purification and isolation of compounds in larger quantities. They are widely used in pharmaceutical development for purifying active pharmaceutical ingredients (APIs), in biotechnology for protein and peptide isolation, and in the food and beverage industry for extracting natural products. These columns are also valuable in research settings for scaling up methods developed on analytical columns to preparative levels while maintaining resolution and purity.

3. What stationary phases are available for Waters preparative columns?
Waters preparative columns offer a variety of stationary phases to meet diverse application needs. Common options include silica-based phases, such as C18, C8, and C4, for reversed-phase chromatography, as well as polar phases for normal-phase chromatography. Specialized phases, like those designed for chiral separations or ion-exchange processes, are also available. The broad selection of stationary phases ensures compatibility with a wide range of analytes and separation techniques, providing flexibility and precision in purification workflows.

4. Are these columns compatible with all solvents and pH ranges?
Waters preparative columns are designed for broad solvent compatibility, making them suitable for a variety of mobile phases used in reversed-phase, normal-phase, and other chromatography techniques. The pH compatibility typically ranges from 1 to 12, depending on the specific stationary phase and column type, allowing users to work with acidic, neutral, and basic conditions.