LiveID Software

LiveID Software

Real-time sample recognition

Real-time sample recognition

LiveID Software enables real-time sample classification using direct analysis mass spectrometry (MS). Get the information you need immediately at the time of analysis for informed, real-time decision-making that removes doubt from sample identity.

LiveID Software can be used with direct mass data generated from a Waters RADIAN ASAP Direct Mass Detector, or quadrupole time-of-flight data generated from Waters Xevo G3 QTof or SYNAPT XS HRMS instruments fitted with a REIMS source.

LiveID Software

Overview

  • Access the power of MS technology without laborious sample preparation
  • Carry out high throughput applications with ease and accuracy
  • Attain accurate molecular profiling in seconds
  • Screen samples against a library of compounds in real time
  • Achieve accuracy and confidence in sample identity
  • Interpret results quickly and easily

Recommended Use: For real-time sample classification at time of analysis.

Features Header

Features Header

Fast analysis for a variety of applications

The process is fast, simple, and robust with no requirements for up-front sample preparation. Direct analysis MS measures a range of compounds in an unbiased fashion providing a holistic molecular profile of the chemical components within a sample. LiveID Software has a visually modern, attractive, web-based interface that offers a workflow-driven process which is easy to learn and use. Initially, authentic verified samples are used to create and validate a statistical model. Validated models can then be used with test samples to generate live classifications. The output is a simple to interpret yes/no answer.

Application areas are extensive and include:

  • Confirmation of sample authenticity for foods and bulk chemicals
  • Food fraud
  • Plant phenotyping in herbicide research
  • Microbe classification
  • Bioengineering research

LiveID is intended for research and commercial use only and not for diagnostic use.

Real time library matching

LiveID is also capable of real time library matching workflows, where the software matches all compounds in the library against each sample analyzed, giving a score out of 1000, where values close to 1000 indicate it is likely the compound of interest is in the sample; lower scores indicate it is unlikely to be present in the sample.

Direct analysis MS data

Direct analysis MS data is imported into LiveID. Shown is a total ion chromatogram from ten collections and an example MS spectrum combined from the area highlighted in orange.

Principal component analysis (PCA) and linear discriminant analysis (LDA)

After MS data is imported, PCA and LDA are used to build a statistical model of the samples under examination. Shown is a PCA-LDA plot of data from five classes of white fish (cod in yellow, coley in red, haddock in green, pollock in purple, whiting in brown; n= 50–194 different samples of fish per class, with 8–12 ROIs collected per sample).

Classified data for live recognition

Once a statistical model is built with authentic samples and validated, it can be used for live recognition. The image shows data from nine measurements that have been classified as chop or liver. For more information about the identity of chemical components observed from samples, MS data can be further analyzed offline in Progenesis QI. 

Resources

Documents

Documents

Support

Support

What do you want to do?

What do you want to do?
Need Help?

Related

REIMS Research System with iKnife Sampling Device
For accurate molecular profiling in seconds, equip your lab with the Rapid Evaporative Ionization Mass Spectrometry (REIMS) Research System with iKnife Sampling Device and time-of-flight (ToF) MS.

RADIAN ASAP Direct Mass Detector
For rapid, easy, low-cost sample analysis of liquids and solids in single quadrupole mass spectrometry applications, equip your lab with the RADIAN ASAP Direct Mass Detector.

Xevo G3 QTof
Characterize your analytes using QToF mass spectrometry and expand your lab’s capabilities with a true analytical workhorse, the Xevo G3 QTof MS system.

Progenesis QI Software
Accurately and confidently perform omics analysis with Progenesis QI Software, an LC-MS data analysis solution that generates reliable, reproducible results.
Back To Top Back To Top

LiveID Software is an innovative platform designed for real-time data analysis and classification in conjunction with direct analysis mass spectrometry (MS) techniques. This software enhances the efficiency of sample identification, allowing users to make informed decisions quickly during the analysis process. Its ability to provide immediate feedback is particularly valuable in critical fields such as clinical diagnostics, environmental monitoring, food safety, and pharmaceutical quality control, where timely decision-making is essential.

A key feature of LiveID is its integration with direct analysis techniques, such as Desorption Electrospray Ionization (DESI) and Direct Analysis in Real Time (DART) mass spectrometry. These methods facilitate rapid sample analysis without the need for extensive preparation, significantly reducing the time between sample collection and result generation. This capability accelerates workflows and enhances productivity, making it ideal for laboratories that require swift operational turnaround.

The software employs advanced informatics, utilizing sophisticated algorithms and machine learning models to automate the classification and identification of compounds from complex mass spectral data. This automation minimizes manual data interpretation, reduces the likelihood of human error, and ensures high accuracy in results. Users can also create and train customized classification models, which can be refined over time as more data becomes available, making LiveID adaptable to various specialized laboratory needs.

With a user-friendly interface, LiveID caters to both experienced scientists and those new to mass spectrometry. The intuitive design allows users to easily input data and view results, supported by visual representations that enhance understanding. Additionally, the software automates essential data processing tasks, such as background subtraction and peak picking, which further streamlines the workflow and allows users to focus on higher-level analysis.

LiveID"s versatility extends across multiple industries. In pharmaceuticals, it aids in rapid screening for active ingredients and contaminants, while in food safety, it detects adulterants. Environmental labs can use it for classifying pollutants in various samples. The software also generates comprehensive reports for regulatory compliance, providing detailed documentation of analyses and ensuring adherence to necessary protocols.