UniSpray Ion Source

UniSpray Ion Source

Ionize a broader range of compounds

Ionize a broader range of compounds

UniSpray is a new form of ionization invented and developed exclusively by Waters. This innovative new source provides more comprehensive ionization than with any other single technique, allowing users to see more of their sample from a single analysis.

Compared to electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI) or atmospheric pressure photoionization (APPI), Waters UniSpray can ionize a broader range of compounds and unlock the potential for increased sensitivity.

With features like the single-piece probe design and target pin, users can significantly reduce the need to change ionization source between different analyses and achieve easy tool-free routine maintenance.

Waters UniSpray ion source enables your lab to see more of your sample in a single analysis. UniSpray Ion Source
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Overview

  • Achieve greater ionization efficiency with a broader range of compounds ionized in a single run and potential for increased sensitivity
  • Save time and increase productivity and efficiency by reducing the need to change ionization source between different analyses
  • Minimize and simplify routine maintenance with tool-free routine maintenance for capillary and target pin replacement

Recommended Use: For ionizing a broader range of analytes in a single run.

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Expand the breadth of your ionization

The unique geometry of the UniSpray ion source generates several different mechanisms to produce smaller droplets and enhance desolvation. These effects combine to generate a greater number of free ions from the same amount of sample when compared to traditional ionization modes like electrospray and typically results in an increase in response across a wide range of compounds.

The combination of a broader range of analytes and a potential boost in response give users the possibility to consolidate several analysis methods into one, or even just remove the need to change over sources between analyses, saving them time and increasing their lab efficiency.

Robust, reproducible, and easy to use

The single-piece probe design and bespoke probe adjuster on the UniSpray ion source enable simple optimization and tool free routine maintenance of the UniSpray source, ensuring you get the same results, no matter who operates and maintains your instrumentation. In a study of 1000 injections of protein precipitated plasma, analyzing for caffeine, <3% relative standard deviation (RSD) was observed across the entire series of injections, showing excellent reproducibility.

High efficiency, broad applicability

Available on the full range of Waters Universal Ion Source compatible mass spectrometers, UniSpray expands the scope of your analysis by enabling a wider range of analytes to be ionized in a single run and delivering results for more compounds than ever before without having to change sources.

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The UniSpray Ion Source is an advanced ionization technology designed to enhance the performance and efficiency of Mass Spectrometry (MS). Unlike traditional methods such as Electrospray Ionization (ESI), Atmospheric Pressure Chemical Ionization (APCI), and Atmospheric Pressure Photoionization (APPI), UniSpray can ionize a broader range of compounds in a single analysis, making it an ideal choice for diverse and complex samples.

UniSpray stands out for its ability to generate more ions from a given sample. Its unique design produces smaller droplets that evaporate more efficiently, leading to a higher number of free ions. This improves the sensitivity of MS, enabling the detection of a wider variety of compounds, even in challenging sample matrices. The system uses a high-speed spray directed at a charged cylindrical target, creating multiple ionization pathways simultaneously. This innovative setup allows for the analysis of diverse compounds without needing to switch between ionization modes, saving time and simplifying workflows.

Ease of use is another strength of the UniSpray Ion Source. Its straightforward design includes a single-piece probe and an adjustable setup that does not require specialized tools for maintenance. This makes it user-friendly, ensures consistent results, and minimizes downtime caused by equipment adjustments or repairs.

UniSpray is particularly beneficial for laboratories analyzing samples with a wide range of compounds. By accommodating various analytes in a single run, it eliminates the need for multiple analyses, increasing productivity and streamlining processes. However, like any advanced system, regular maintenance is necessary to ensure optimal performance. Over time, inorganic salts may build up on the impactor, especially when using water-heavy samples. To address this, labs can use flow diversion techniques during certain phases of the analysis to prevent sensitivity loss.

To conclude, the UniSpray Ion Source is a significant advancement in mass spectrometry, offering higher sensitivity, broader analyte coverage, and improved efficiency. Its innovative design and ease of maintenance make it a valuable tool for laboratories looking to enhance their analytical capabilities and streamline workflows.