Small Molecule LC/MS Standards

Small Molecule Standards

Easily test, evaluate, validate, and troubleshoot applications

Easily test, evaluate, validate, and troubleshoot applications

Ultra-Performance Liquid Chromatography (UPLC) combined with mass spectrometric (MS) detection is used successfully in the analysis of small molecules. The Waters Small Molecule Standards consumable line provides relevant application-specific standards for evaluating and running many small molecule applications, including MetID, omics, bioanalysis, and extractables and leachables.

Waters Small Molecule Standards can be used to test, validate and troubleshoot applications, including MetID, Omics, bioanalysis, and extractables and leachables. Small Molecule Standards
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Specifications

Overview

  • Reduce variability, rework, and paperwork
  • Save time with predetermined, stable mixes specific to applications
  • Test, validate, and troubleshoot applications 

Recommended Use: For evaluating, validating, and troubleshooting many MetID, Omics, bioanalysis, extractables and leachables applications.

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Analgesic Mix

Waters Analgesic Mix is specifically for small molecule work and experiments with scaling of a system from HPLC to UPLC in this application area. This 7-compound mix is comprised of acetominophen, acetomidophenol, acetanilde, acetylsalicylic acid, caffeine, phenacetin, and salicylic acid.

System Evaluation Matrix #1

The System Evaluation Matrix #1 is intended for use as a reproducible background signal in the evaluation of LC and MS system performance. It is especially suitable for standard small molecule applications where a complicated matrix is required but naturally occurring alternatives, such as urine and plasma, are impractical.

MetID Small Molecule Standard Mix

The MetID standard is a 3-component mix of omeprazole and 2 metabolites used for validation of the Waters Metabolite Identification system and software.

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Quality Control Reference Materials
Ensure peak LC and LC-MS column and system performance by benchmarking with Waters Quality Control Reference Materials, a portfolio of ready-to-use standards and mixes.

Sample Vials
Reduce failed assays with Waters glass and plastic autosampler vials and high sample recovery vials - certified/tested by HPLC, GC, and MS.

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Small molecule LC/MS standards are high-purity, well-characterized compounds designed for liquid chromatography-mass spectrometry (LC/MS) workflows. These standards serve as reliable reference materials, ensuring accurate identification, quantification, and validation of small molecules in various fields. They are essential for achieving precise, consistent, and repeatable results, making them indispensable for scientists and researchers.

The high purity of these standards, typically exceeding 98%, minimizes background interference and ensures clean, reliable data. Each standard undergoes rigorous testing to confirm its chemical structure and consistency. Accompanied by detailed documentation like Certificates of Analysis (CoAs), these standards guarantee traceability and compliance with regulatory requirements.

Small molecule LC/MS standards are used across many industries. In pharmaceuticals, they ensure the consistency of active ingredients in drugs and detect impurities. In food and beverage testing, they help monitor contaminants, verify additives, and measure nutritional components. Environmental scientists use them to detect pollutants and pesticide residues, while researchers in metabolomics rely on them to analyze biological processes and discover potential biomarkers for diseases.

The advantages of using LC/MS standards include improved accuracy, streamlined method validation, and compliance with global regulatory guidelines like those from the FDA, USP, and EP. These standards provide consistent and dependable reference points, boosting confidence in results and simplifying complex analytical workflows.

To conclude, small molecule LC/MS standards are critical tools in modern science. Their exceptional quality, adaptability, and regulatory alignment make them vital for advancing accuracy and innovation in small molecule analysis.