BioResolve SCX mAb, 3 μm, corrosion–resistant columns which contain non-porous, polymer-based particles grafted with a rigorously-optimized, multi-component network of negatively charged sulfonic acid ligands. This innovative column technology, delivers reproducible, high-resolution, charged-based separations of mAbs and other proteins in both LC and LC-MS applications using robust salt or pH gradient methods. This P/N also contains one vial of the mAb Charge Variant Standard (P/N 186009065)
pH Range Min |
3 pH |
Bonding Technology |
SCX |
Particle Shape |
Spherical |
Particle Size |
3 µm |
QC Tested |
Protein |
Format |
Column |
System |
HPLC, UHPLC, UPLC |
Inner Diameter |
2.1 mm |
Length |
50 mm |
eCord |
Yes |
UNSPSC |
41115709 |
Application |
Protein |
Brand |
BioResolve |
Product Type |
Columns |
Units per Package |
1 pk |
BioResolve SCX mAb Column, 3 µm, 2.1 mm x 50 mm, 1/pk with mAb Charge Variant Standard
A wide variety of monoclonal antibodies are frequently separated properly and consistently with charge variant quantification using strong cation-exchange analysis. However, a chromatography column that can easily tolerate chromatographic conditions is required for SCX analysis to be successful. In order to assist you to get through those difficulties, the BioResolve SCX mAb Column provides the flexibility and rigidity you need. And because this column offers charge variation analysis of mAbs and other proteins, we provide LC-MS users with a platform that uses strong salt and pH gradient techniques to boost your analyses. Buy a BioResolve Column right away to experience how crucial it can be to your mAb analysis workflow, or inform your lab management that you need access to one.
This lab equipment includes the mAb Charge Variant Standard. In charge variant chromatography employing BioResolve SCX columns, this standard is intended to aid in benchmarking the process. It includes tryptophan, conalbumin, and the NIST RM 8671, three distinct intact proteins that are important to Biopharma's clients (NIST mAb). Additionally, every batch of BioResolve SCX mAb material is quality-controlled using this standard.
The non-porous polymeric particles inside the BioResolve SCX mAb Column actively strive to reduce analyte band spread to increase mAb separations, which also gives you superior component recovery, peak shape, and component resolution. And because we care so much about how you use this column for method development, we have set it up to have a low injection-to-injection carryover rate during method transfer. In addition to this, this column is LC system independent, allowing for unrestricted use on all UHPLC, HPLC, and UPLC systems. You can repeatedly obtain strong and high-resolution mAb separations in this method.
Waters provides much more than only BioResolve SCX mAb Columns to help you comprehend the creation of biotherapeutic drugs. Also available are solution packages to improve your workflow, lab informatics, and data management software, quality control reference materials, and everything else you need to run a successful lab. Shop for lab equipment to equip your lab with all you need.
You may also want to learn more about the BioResolve CX pH Concentrate pH 5 and pH 10.2 Kit.
How Can I Clean the BioResolve SCX mAb Column?
Several different cleaning solutions can be used to properly clean the BioResolve SCX mAb Column. Please refer to the BioResolve SCX mAb Column Care and Use Manual for specific instructions.