Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs! Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs!
SKU: 186000492 XTerra Shield RP18 Column, 125Å, 5 µm, 4.6 mm X 150 mm, 1/pk
XTerra RP18 columns are general purpose, hybrid-based, reversed-phase C18 columns that incorporate Waters patented embedded polar group technology to improve peak shape performance for highly basic compounds. These first generation columns provide superior pH stability compared to a silica-based column.
XTerra Shield RP18 Column, 125Å, 5 µm, 4.6 mm X 150 mm, 1/pk
The fastest-selling and most successful column product in the world of chromatography, the XTerra Shield RP 18 columns has enabled scientists to make use of Hybrid Particle Technology across industries. For drug discovery scientists, the DMSO injection resistance of the rugged XTerra particle offers benefits. Method development scientists are able to operate at any pH necessary for optimal selectivity because of the wide pH range offered by XTerra, and isolation and purification scientists will be able to load up to 60 times more material per injection because of the high mass loading capacity.
The XTerra Shield RP18 Column allows chromatographers to overcome common restrictions on HPLC separations on resolution, speed, pH, temperature, and loading capacity. The Hybrid Particle Technology of XTerra not only overcomes these challenges, but also helps chromatographers realize the full potential of analytical and preparative separations. With this technology, one of every 3 silanols is replaced with a methyl group during synthesis, distributing the hydrophobicity throughout the entire structure of the particle. This allows for a rugged hybrid particle to be operated at high speeds, high temperatures, and high pHs. With 33% fewer residual silanols, XTerra Shield RP18 Columns offer sharp and high-efficiency peaks for basic compounds.
XTerra Shield RP18 columns combine the Hybrid Particle Technology with Waters’ Shield Technology, incorporating an embedded polar group in order to deliver the best possible peak shape. As a general-purpose, universal column, they facilitate fast method development with unique selectivity. Like all XTerra columns, the XTerra Shield RP18 Column has superior water wettability, even in 100% aqueous mobile phases. This combination of a greatly widened pH range for selectivity choices and the added selectivity options of two ligands can be the only tools needed for successful method development.
Different features of the XTerra columns can be beneficial for chromatographers in a variety of fields.
For those working in drug discovery, the rugged and efficient nature of Hybrid Particle Technology is resistant to the DMSO injections that are performed often. These small particles can be packed into short columns, allowing faster gradients and shortened analysis time. This offers drug discovery scientists high throughput, minimized sample backups, and faster library screening.
Methods development scientists operate under conditions that improve optimal selectivity- the wide pH operating range of XTerra enables these scientists to harness the pH for faster and easier development of robust, reproducible separations.
What is HPLC?
High-performance liquid chromatography (HPLC) signifies a cutting-edge analytical technique that plays a pivotal role in separating, identifying, and quantifying constituents within a mixture. Serving as the predominant method adopted in laboratories globally, this test encompasses a multitude of applications, cementing its status as an indispensable tool in the scientific realm.
