SKU: 186009053
BioResolve SCX mAb Column with VanGuard FIT, 3 µm, 2.1 mm X 50 mm, 1/pk

BioResolve SCX mAb Column with VanGuard FIT | 2.1 x 50 mm | 186009053


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Product Description

BioResolve SCX mAb Column with VanGuard FIT, 3 µm, 2.1 mm x 50 mm corrosion-resistant columns which contain non-porous, polymer-based particles grafted with a rigorously-optimized, multi-component network of negatively charged sulfonic acid ligands. This innovative column technology, delivers reproducible, high-resolution, charged-based separations of mAbs and other proteins in both LC and LC-MS applications using robust salt or pH gradient methods. Each batch is specifically QC tested using Waters mAb Charge Variant Standard (p/n: 186009065) to help ensure consistent performance. In addition, this offering includes VanGuard Fully Integrated Technology (FIT) that maximizes column life without degrading biomolecule component resolution.

Note: p/n: 176004341 contains above plus one vial of the mAb Charge Variant Standard (p/n: 186009065)

Suggested Use: Charge Variant Analysis

Specifications

  • pH Range Min

    3 pH

  • Temperature Limits

    60 C

  • Maximum Pressure

    10000 psi (689 Bar)

  • Bonding Technology

    SCX

  • Particle Shape

    Spherical

  • Particle Size

    3 µm

  • QC Tested

    Protein

  • Format

    Column

  • System

    HPLC, UHPLC, UPLC

  • USP Classification

    L34

  • Inner Diameter

    2.1 mm

  • Length

    50 mm

  • eCord

    Yes

  • UNSPSC

    41115709

  • Application

    Protein

  • Brand

    BioResolve

  • Product Type

    Columns

  • Units per Package

    1 pk

Product Support

Documents

Documents



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BioResolve SCX mAb Column with VanGuard FIT, 3 µm, 2.1 mm X 50 mm, 1/pk

Scientists across the globe use charge variant quantitation to accurately assess the development of biotherapeutic drugs and other mAb-based drugs, but such a process requires using robust salts and pH gradient methods, which means whichever analytical column you use should be capable of handling those conditions. And when you buy the BioResolve SCX mAb Column, you get exactly that and so much more. This breakthrough mAb separation tool utilizes a rigorously optimized network of negatively charged sulfonic acid ligands to provide charge variant analysis of monoclonal antibodies and other proteins. These analyses are critical quality attributes to understand for drug development, which is why this column is outfitted with many features to provide clear and reproducible results time and again. Tell your lab manager all about the BioResolve SCX mAb Column now or add one to your cart and have it delivered right to your lab today.

The BioResolve SCX mAb Column is based on non-porous particle technology that’s uniquely designed for optimal protein diffusion kinetics and pressure tolerances across all UHPLC, HPLC and UPLC systems. This resistance to overwhelming chromatographic conditions makes this column a terrific choice for when you need to perform simple-to-implement charge variant profiling. That way you can achieve high resolution and robust separations quickly, easily and efficiently. This is especially important to method development scientists, as this column can rapidly reproduce mAb separations and even offers method transfer features to make that process easier.

The VanGuard FIT cartridge included with this column actively removes contaminants from the mobile phase stream before they reach your analytical column and foul it. Column fouling over time should always be at the forefront of your mind and it’s important to note that this cartridge is not a replacement for proper sample purification protocols. The cartridge should always be used in conjunction with proper column care and use directions. What’s more, this cartridge even upholds mechanical and chemical stability, as it offers the same pH range and sorbent as the BioResolve SCX mAb Column.

Want to upgrade your SCX analyses?
Simply purchase the BioResolve CX pH Concentrate A and BioResolve CX pH Concentrate B. When used together, these concentrates can help you create a pH 5.0 to pH 10.2 gradient for mAb charge variant separations.

At Waters, we have the products and resources for you to take your lab to the next level. From quality control reference materials and other classic chromatography consumables to lab informatics and full LC-MS systems, we truly have it all. Shop lab equipment to discover everything we have to offer.

How Can I Make Charge Variant Profiling Easier with the BioResolve SCX mAb Column?

To make charge variant profiling easier with the BioResolve SCX mAb Column, we recommend adding the BioResolve CX pH Concentrate A (PN# 186009063) and BioResolve CX pH Concentrate B (PN# 186009064) to your workflow, as these robust salts work together with this column to provide simple-to-implement charge variant profiling.