ACQUITY Premier CSH C18 Column 1.7 µm, 2.1 x 100 mm, 1/pk

Waters designed the ACQUITY UPLC CSH C18 Column in response to feedback from various customer forums. When compared to other reversed-phase UPLC columns, the ACQUITY UPLC CSH C18 Column was developed to provide alternate selectivity. These ultra-efficient columns overcome peak shape asymmetry, poor basic compound loading capacity, column bleed, and rapid mobile-phase re-equilibration. The Charged Surface Hybrid (CSH) Technology, which is the next evolution of particle technology, is the driving force behind the ACQUITY UPLC CSH columns. Waters invented the Charged Surface Hybrid (CSH) Technology, which is the driving force behind the ACQUITY UPLC CSH columns.

Method development is faster and easier with the ACQUITY UPLC CSH C18 Column because CSH Technology provides Trifluoroacetic acid (TFA) peak shape performance without the use of TFA. Though the use of Trifluoroacetic Acid results in sharp peak shapes for basic compounds, it is an ion-pairing agent that is difficult to remove from the ACQUITY phase after it has been exposed to a Liquid Chromatography column. The ACQUITY UPLC CSH C18 Column, on the other hand, can deliver improved peak shape performance with MS-friendly mobile phase additives like formic acid. Because formic acid does not act as an ion-pairing agent, method development is sped up and simplified.

The ACQUITY UPLC CSH C18 Column differs from Waters' other ACUITY brands, ACQUITY UPLC BEH and XBridge, in terms of selectivity and range. The ACQUITY UPLC CSH C18 Column provides a wide range of selectivities without sacrificing critical performance characteristics such as peak shape for basic compounds, low column bleed, and seamless transferability between different particle sizes and column formats.

Under acidic, low ionic strength mobile phase conditions, the ACQUITY Premier CSH C18 Column provides increased analytical loadability, delivering sharper, narrower peaks for basic compounds. The increased loadability also allows for the use of a narrower preparative column, reducing solvent consumption and fraction volumes. To shop for lab equipment, check out our catalog or browse our website.

You may also be interested in ACQUITY Premier CSH C18 Column with VanGuard FIT, 1.7 µm, 2.1 x 100 mm, 1/pk. ACQUITY Premier CSH C18 Columns overcome peak shape asymmetry and poor loading capacity for basic compounds when using low ionic strength mobile phase. The surface charge enables fast column equilibration when switching from low to high pH mobile phases.