Oasis MCX 3 cc Vac Cartridge, 60 mg Sorbent per Cartridge, 30 µm, 100/pk

Conduct fast, straightforward method development using the 3 cc OASIS MCX Vac Cartridge, while leveraging the power of dual modes of retention (ion-exchange and reversed-phase) on a single, clean, stable, high-surface-area with organic co-polymer that is stable from pH 0 to 14.

Made using a Waters-patented process, the OASIS MCX is a strong mixed-mode cation exchange, water wettable, polymeric sorbent. It offers higher retention and outstanding recoveries even if the sorbent runs dry, eliminating the need for any efforts required to keep the sorbent beds from drying out during the critical steps prior to sample loading.

Perform tough and robust procedures without analyte breakthrough or loss of recovery due to dissolving silica particles at high pH or cleaning bonded phase at low pH, all due to the ability to manipulate pH during the development, optimization, and use of SPE methods on mixed-mode sorbents with the Oasis MCX 3 cc Vac Cartridge.

Waters OASIS products are the most widely used product range of Sample Extractions Products (SPEs) used in bioanalytical laboratories. The Oasis products are designed to offer the highest SPE recovery, cleanest extracts, lowest matrix effects, and lowest method variability, making them indispensable lab equipment.

Developed to overcome the limitations of the traditional silica-based mixed-mode SPE lab equipment, the OASIS MCX is a novel, mixed-mode polymeric sorbent that has been optimized to achieve higher selectivity and sensitivity for extracting basic compounds with cation-exchange groups. See our full product portfolio, including the 3 cc OASIS MCX Vac Cartridge, and shop for lab equipment for all your method development needs.

The Waters OASIS MCX 3cc Vac Cartridge is compatible with the Oasis MCX 96-well Plate, 60 mg Sorbent per Well, 60 µm, 1/pk.

FAQs About Oasis MCX 3 cc Vac Cartridge, 60 mg Sorbent per Cartridge, 30 µm, 100/pk

1. What types of analytes can be extracted using the Oasis MCX Vac Cartridge?
The Oasis MCX Vac Cartridge is designed for the extraction of basic analytes, making it ideal for compounds with a positive charge at acidic pH levels. It is commonly used for isolating drugs, metabolites, and other basic compounds from complex biological matrices such as plasma, serum, and urine.
The mixed-mode cation-exchange sorbent ensures high selectivity for basic analytes, even in the presence of challenging matrix components. This makes the cartridge suitable for applications in pharmaceutical development, clinical research, toxicology, and environmental analysis where selective and efficient extraction of basic compounds is required.

2. How does the mixed-mode cation-exchange (MCX) sorbent work?
The mixed-mode cation-exchange (MCX) sorbent in the Oasis MCX Vac Cartridge combines two powerful retention mechanisms: reversed-phase and strong cation exchange. The reversed-phase functionality retains hydrophobic compounds, while the cation-exchange functionality selectively binds basic analytes through ionic interactions. This dual functionality allows for efficient extraction and cleanup of basic compounds, even from complex sample matrices.
The strong cation-exchange mechanism is pH-dependent, requiring acidic conditions during sample loading to protonate the basic analytes, enabling strong binding to the sorbent. This design ensures high recoveries and excellent selectivity for basic analytes.

3. What are the best practices for avoiding clogging or channeling during sample loading?
To avoid clogging or channeling during sample loading with the Oasis MCX Vac Cartridge, ensure that your samples are properly pre-treated and filtered to remove particulates. Using a syringe filter or centrifuging the sample prior to loading can significantly reduce the risk of clogging. Load the sample at a consistent, moderate flow rate to prevent uneven distribution across the sorbent bed.