Ostro protein precipitation and phospholipid removal 96-well plate for pass-through sample preparation

SKU: 186005518
Ostro Protein Precipitation & Phospholipid Removal Plate, 25 mg, 1/pk

Ostro Protein Precipitation and Phospholipid Removal Plates | 186005518


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Product Description

Ostro sample preparation products provide a novel solution for the cleanup of phospholipids in plasma and serum. Requiring minimal to no method development and using a simple protocol, the technology can be quickly implemented in order to optimize your laboratory's work flow. Providing cleaner, more reproducible extracts than competitive phospholipid devices or techniques, Ostro allows for more sensitive analyses, increased sample throughput, and reduced instrument downtime.

Specifications

  • UNSPSC

    41115712

  • Brand

    Ostro

  • Product Type

    Solid Phase Extraction

  • Units per Package

    1 pk

  • Endcapped

    No

  • Format

    96-well Plate

  • Mass Spec Compatibility

    Yes

  • Sorbent Weight

    25 mg

  • Water Wettable

    Yes

  • pH Range Min

    0 pH

  • pH Range Max

    10 pH

  • Material

    Polypropylene

  • Number of Wells

    96

Product Support

Documents

Documents



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Ostro Protein Precipitation & Phospholipid Removal Plate, 25 mg, 1/pk

As part of the Ostro Pass-Through Sample Preparation family of products, the Ostro Protein Precipitation & Phospholipid Removal Plate contributes to a simple solution for scientists looking to perform sample cleanup. Waters" Ostro Protein Precipitation & Phospholipid Removal Plate enable rapid sample processing that requires little to no method development, reproducible sample cleanup that allows more predictable analyses, and less system downtime as a result of contamination of columns and instruments from dirty samples. The 96-well plate format used in this product enables higher throughput and is compatible with automation and a variety of complex sample matrices.

The Ostro Protein Precipitation & Phospholipid Removal Plate offers a novel approach to the removal of phospholipids from biological samples, with an in-well protein precipitation that is used in combination with a single, rapid, pass-through method. This pairing provides consistent, high extraction recoveries for acids, bases, and neutrals alike. With the goals of a bioanalytical scientist in mind, Ostro Protein Precipitation & Phospholipid Removal Plates can enhance performance by providing excellent reproducibility, improved recovery, and increased phospholipid removal when compared with other, competitive techniques.

The Ostro Protein Precipitation & Phospholipid Removal Plate can be quickly implemented into routine protocols, producing clean extracts and superior reproducibility and resulting in consistent, robust methods with higher throughput. This makes the plate suitable for forensics, toxicology, bioanalysis, and food or beverage analysis, offering these scientists easy implementation and speed, avoiding long methods development periods.

Waters strives to provide predictable performance through reproducibility, and the Ostro Pass-Through Sample Preparation products, including plates, are manufactured to deliver excellent recovery across batches of products, giving scientists confidence in their analysis. The in-well protein precipitation is designed using a straight forward, 6 step procedure intended to help produce filtrates free of proteins and other endogenous components. These filtrates are highly suited to high-throughput LC/MC/MS analysis.

Explore Waters" collection of superior lab equipment products, and search for related products to improve your work, such as our Oasis Method Development Sorbent Selection Plate, 10 mg Sorbent per Well, 30 µm, 1/pk.

FAQs About Ostro Protein Precipitation & Phospholipid Removal Plate, 25 mg, 1/pk

1. What types of samples can be processed using the Ostro Plate?
The Ostro Protein Precipitation & Phospholipid Removal Plate is designed to process biological samples such as plasma, serum, and whole blood. It is particularly effective for samples that require both protein precipitation and the removal of phospholipids to prepare analytes for downstream analysis.
This plate is suitable for complex matrices commonly encountered in pharmaceutical, clinical, and toxicology workflows. By efficiently removing unwanted matrix components, the Ostro Plate ensures clean extracts that improve analytical performance in techniques such as LC-MS and HPLC.

2. Is the Ostro Plate compatible with high-throughput workflows?
Yes, the Ostro Plate is fully compatible with high-throughput workflows. Its 96-well format is specifically designed for automated and semi-automated systems, allowing for the simultaneous processing of multiple samples. This high-throughput capability makes it an excellent choice for laboratories handling large sample volumes, such as those in pharmaceutical development or clinical research.
The plate's design minimizes manual intervention, streamlines sample preparation, and reduces processing time, enabling efficient and reproducible results for high-throughput analytical workflows.

3. Can the plate be used for both plasma and serum samples?
Yes, the Ostro Plate is suitable for use with both plasma and serum samples. Its dual-functionality design efficiently removes proteins and phospholipids from these biological matrices, resulting in clean extracts ready for analysis. Plasma and serum samples, often laden with proteins and lipids that can interfere with LC-MS or HPLC, benefit from the plate's ability to improve analyte recovery and enhance sensitivity. This versatility makes it an ideal solution for applications in clinical research, pharmaceutical analysis, and toxicology studies.

What is methods development?

Methods development is a continuous process that occurs in parallel with the creation and evolution of drug products. This time is used to prove that an analytical method is an acceptable way to measure the concentration of an active pharmaceutical ingredient in a specific compounded dosage form, allowing simplified procedures to be used for verification. This verification seeks to show that an analysis procedure accurately and consistently shows a reliable measurement. A successfully developed and validated method is able to reduce overall turnaround times to commercial release of a drug or substance, making it important to many scientists to achieve.

What is a phospholipid?

A phospholipid is a type of lipid molecule that is the main component of the cell membrane. Lipids are molecules that include fats, waxes, and some vitamins, among others. Each phospholipid is made up of two fatty acids, a phosphate group, and a glycerol molecule.