Oasis HLB 96-well Plate, 30 mg Sorbent per Well, 30 µm, 1/pk
Improve the recovery and overall reproducibility of your SPE method with the OASIS HBL 96-well plate that gives you the unique advantage of having higher retention capacity [k] so that more analytes are retained with less breakthrough. The OASIS HLB is a Hydrophilic-Lipophilic-Balanced, water-wettable, reversed-phase universal sorbent for acidic, neutral, and basic compounds for all your SPE needs. Enjoy key features of this unique substrate, including stability at pH extremes and in a wide range of solvents, extraordinary retention of polar compounds, and a relative hydrophobic retention capacity 3 times higher than that of traditional silica-based SPE sorbents.
The Waters OASIS HLB sorbent empowers you to make your product selection based on viscosity, volume, and turbidity of your sample and gives you the choice between five particles sizes [5µm, 15µm, 25µm, 30µm, 60µm].
With the OASIS HLB, your methods will be more robust, eliminating the need for repeat preparation as even if the sorbent bed runs dry during the conditioning or sample loading, the water-wettable quality of OASIS Sorbents ensures outstanding retention capacity across a wide range of polarity spectrum of analytes. The 96-well OASIS HLB plate has a unique balance of water-wettability and hydrophobicity, freeing you of the worry about poor results if the individual wells dry out during steps prior to sample loading.
Shop for lab equipment and see our entire product portfolio, and explore the Oasis HLB 96-well Plate, 60 mg Sorbent per Well, 60 µm, 1/pk in varying particle size options.
Oasis HLB 96-well Plate, 30 mg Sorbent per Well, 30 µm, 1/pk FAQs
What are the advantages of using a 96-well plate format for SPE?
The Oasis HLB 96-well Plate offers significant advantages for high-throughput solid-phase extraction (SPE), making it ideal for laboratories processing large sample volumes efficiently. Unlike traditional SPE cartridges, the 96-well plate format allows for simultaneous processing of multiple samples, reducing sample preparation time and improving workflow efficiency.
The consistent sorbent bed height and packing across all wells ensure uniform extraction and reproducibility, which is critical for regulated analyses such as pharmaceutical, clinical, and environmental testing. Additionally, the automation compatibility of 96-well plates enables integration with liquid handling systems, further improving throughput and minimizing manual errors.
Another key advantage is the small elution volume, which reduces the need for evaporation and reconstitution, making the plate particularly useful for LC-MS/MS applications requiring high sensitivity and minimal sample handling.
What types of analytes can be extracted using this plate?
The Oasis HLB 96-well Plate is designed for broad-spectrum solid-phase extraction (SPE), efficiently retaining both polar and nonpolar compounds. It is commonly used for pharmaceutical, clinical, forensic, food safety, and environmental applications, allowing for the extraction of small molecules, drugs, metabolites, pesticides, and hormones from biological and environmental samples.
The Hydrophilic-Lipophilic Balance (HLB) sorbent enables the retention of a wide range of analytes, making it highly versatile compared to traditional silica-based SPE materials. This sorbent is particularly effective for biological fluids (e.g., plasma, urine, and serum), ensuring high recovery and reproducibility for drug analysis, biomarker discovery, and toxicology studies. Its compatibility with various aqueous and organic solvents allows for flexible method development across different sample types.
Can this plate be used for both acidic and basic compounds?
Yes, the Oasis HLB 96-well Plate is suitable for extracting both acidic and basic compounds, making it a versatile choice for SPE applications. The HLB sorbent's balanced hydrophilic-lipophilic properties allow it to retain a broad range of analytes, regardless of their ionization state.
For acidic compounds, elution is typically performed using low-pH solvents such as formic acid or trifluoroacetic acid in methanol or acetonitrile. For basic compounds, higher-pH eluents such as ammonium hydroxide in organic solvents enhance recovery.
