Extractables & Leachables Screening Standard

Extractables & Leachables Screening Standard contains samples of common industry extractable and leachable compounds used to reliably evaluate system preparedness for non-targeted screening and unknown compound analysis. It is intended to be used as a benchmark or system suitability test standard as it contains an 18-component mixture.

The components were selected based on a few key factors such as compounds that are representative of common industry polymer additives and preservatives, contain components that ionize in both positive and negative MS modes and compounds that enable you to cover a wide screening mass range.

The Extractables & Leachables Screening Standard covers a mass range of up to 1176 Da, supporting both positive and negative ionization modes. These compounds were specifically chosen due to their stable retention times and easy evaluation of mass accuracy. By selecting the Extractables & Leachables Screening Standard, you can simplify your screening workflow and eliminate time-consuming standard preparation steps when analyzing samples for unknown contaminants.

The standard mix is provided in a Waters Crimp Top vial for direct injection and contains the following compounds in 2 mL MeOH:

• Irganox 1010 (1 µg/ml+/- 1%)
• Irganox 245 (0.1 µg/ml+/- 1%)
• Irganox 1076 (1 µg/ml+/- 1%)
• Irganox 1098 (0.1 µg/ml+/- 1%)
• Cyasorb 2908 (0.1 µg/ml+/- 1%)
• Uvinul 3030 (0.1 µg/ml+/- 1%)
• Propylparaben (0.1 µg/ml+/- 1%)
• Ethanox 330 (Irganox 1330) (1 µg/ml+/- 1%)
• Tinuvin 327 (1 µg/ml+/- 1%)
• Diethyl phthalate (0.1 µg/ml+/- 1%)
• Diphenyl phthalate (0.1 µg/ml+/- 1%)
• Tris(p-cresyl) phosphate (TCP) (0.1 µg/ml+/- 1%)
• 2-hydroxy-4-octyloxy benzophenone (0.1 µg/ml+/- 1%)
• Tinuvin P (1 µg/ml+/- 1%)
• Uvitex OB (0.1 µg/ml+/- 1%)
• Tinuvin 360 (1 µg/ml+/- 1%)
• Dibutyl sebacate (0.1 µg/ml+/- 1%)
• Methylparaben (0.1 µg/ml+/- 1%)

It is recommended to store the Extractables & Leachables Screening Standard at 4°C ± 2°C and to keep it refrigerated.

You can browse our website to shop for lab equipment to fulfill your laboratory needs. We also recommend checking out the Reversed-Phase QC Reference Material; the Reversed-Phase QC Reference Material contains 7 compounds, including uracil, butyl paraben, naphthalene, propranolol, dipropyl-phthalate, acenaphthene, and amitriptyline at pH 7. This standard mix should be used to confirm the benchmark performance of your analytical HPLC or UPLC system. This particular QC Reference Material is a specially formulated mix that includes a void marker, neutral, acidic, and basic compounds.