Humanized mAb Mass Check Standard

Invest in the Waters Humanized mAb Mass Check Standard to your lab equipment collection. The analysis of intact proteins by LC-MS is a preferred approach for the characterization of biopharmaceuticals, in particular, monoclonal antibodies (mAbs). In such an analysis, it is possible to acquire intact mass information, quickly confirm sequence and post-translational modifications, as well as interrogate product-related impurities. To support this application area, Waters has commercialized the Humanized mAb Mass Check Standard, which can be used in the benchmarking of LC-MS techniques, proficiency testing among different instruments and laboratories, and system suitability when doing intact protein analysis. This lab equipment is a stabilized and lyophilized format of NIST Reference Material 8671 (NIST mAb), a humanized IgG1κ expressed from a murine cell line.* Each vial of the standard is provided in an approximately 80 µg quantity.

The reagents and standards you select will have a direct impact on the quality of your chromatographic results as well as the final products. With this in mind, Waters invests much in research in order to develop the best quality standards and reagents that can be used in labs all around the world. All of our standards and reagents are manufactured to exact specifications and are completely traceable. This is because we recognize that the capacity to prepare reference materials identically over long periods of time is critical for data comparability in analysis. Furthermore, the measurements must be linked to a source reference material through a clear, unbroken, and well-documented chain of comparisons.

You may also be interested in the mAb Subunit Standard. The Waters mAb Subunit Standard can be used for LC and LC-MS technique benchmarking, proficiency testing between different equipment and facilities, and system appropriateness. NIST Reference Material 8671 (NIST mAb), a humanized IgG1 produced from a murine cell line, is a filtered and stabilized formulation of reduced, IdeS-digested NIST Reference Material 8671 (NIST mAb). Each vial of the standard contains approximately 25 µg of material.