mAb Size Variant Standard

Testing your LC system for its ability to separate monoclonal antibody aggregates can sometimes be difficult, but it doesn’t have to be when you have the mAb Size Variant Standard to help. This helpful LC- MS standard has been specially formulated to help verify your LC system’s ability to detect monoclonal antibody aggregates. To do such an important task, the standard includes the NIST humanized monoclonal antibody (Reference Material 8671) and non-reduced IdeS digested NIST mAb fragments. Since this standard succeeds in aliquoting small amounts of IdeS fragments, this standard can be used to effectively test both LC systems and instruments, including columns. What’s more, if you need any other quality control reference materials or chromatography standards, we have exactly what you need at Waters. Add the mAb Size Variant Standard to your lab’s next order from Waters, or simply purchase your own vial and have it shipped directly to the lab.

The mAb Size Variant Standard answers the difficult-to-discover query of if your LC systems and instruments are capable of detect monoclonal antibodies, but also separate mAb aggregates, monomers and fragments/clips via size-exclusion chromatography. As many scientists across the world know, monoclonal antibody analysis can be performed with a great deal of clarity when using size-exclusionary chromatographic techniques. But to achieve that clarity, you still need your LC system to be operating at peak performance. The mAb Size Variant Standard is here to ensure exactly that.

If you’re looking for the right separation tool for monoclonal antibody aggregates, then consider the BioResolve SEC mAb Column with BioResolve SEC mAb Guard. This breakthrough column is specially designed to ensure accurate and reliable quantitation of monoclonal antibody monomers from frequently associated high and low molecular weight fragments.

Read to add the mAb Size Variant Standard to your lab’s toolkit?
Before doing so, make sure to check around your lab to see if any essentials need to be ordered. That’s because at Waters, we have a complete line of lab essentials and all the breakthrough equipment you’ll want to upgrade your lab with. Shop lab equipment to explore our offerings.