Dioxins and Furans

Dioxins and Furans

Dioxin analysis is complex, with low level regulatory limits and complex sample matrices. With cutting-edge instrumentation and solutions from Waters, laboratories in food, feed and environmental industries can make increasingly sensitive dioxin and furan measurements.

Dioxin analysis is complex, with low level regulatory limits and complex sample matrices. With cutting-edge instrumentation and solutions from Waters, laboratories in food, feed and environmental industries can make increasingly sensitive dioxin and furan measurements.

Air pollution from factory
Air pollution from factory

Overview

Dioxins are bio-accumulative persistent organic pollutants (POPs) largely formed during combustion processes and are found throughout the environment. Dioxin analysis is particularly demanding due to low level regulatory exposure limits and complex sample matrices.

Cutting-edge instrumentation, such as Waters Xevo TQ-XS with APGC, enables laboratories in food, feed, and environmental industries to make increasingly sensitive measurements from complex samples and allows updated recommendations to be made on regulatory limits. With Waters solutions, you can:

  • Confidently adopt APGC-MS/MS as an alternative to traditional HRMS analysis for best-in-class sensitivity
  • Exceed analytical performance of legacy magnetic sector instruments and electron ionization MS/MS systems offered by other manufacturers
  • Improve robustness for increased productivity
  • Support success with commercial laboratory validation and regulatory acceptance

Applications

Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) are toxic compounds categorized as persistent organic pollutants (POPs), commonly known as dioxins and furans, bringing considerable health risks. Approval of a new method that uses GC-MS/MS to determine these compounds takes advantage of the advances made in tandem quadrupole MS over the decades, offering the potential to lower laboratory costs.

Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) are toxic compounds categorized as persistent organic pollutants (POPs), commonly known as dioxins and furans, bringing considerable health risks. Approval of a new method that uses GC-MS/MS to determine these compounds takes advantage of the advances made in tandem quadrupole MS over the decades, offering the potential to lower laboratory costs.


Fire debris


Case Study: SGS AXYS and Waters Validate APGC as New Methodology for Dioxin and Environmental Contaminants Analysis

Using Waters APGC coupled with the Xevo TQ-XS Triple Quadrupole Mass Spectrometer, scientists at SGS AXYS worked closely with Waters to develop and validate an alternative procedure for polychlorinated dibenzo dioxins and furans by EPA method 1613B using GC-MS/MS, at the request of US EPA. This case study highlights the numerous benefits this method offers for dioxin and environmental contaminant analysis.

Using Waters APGC coupled with the Xevo TQ-XS Triple Quadrupole Mass Spectrometer, scientists at SGS AXYS worked closely with Waters to develop and validate an alternative procedure for polychlorinated dibenzo dioxins and furans by EPA method 1613B using GC-MS/MS, at the request of US EPA. This case study highlights the numerous benefits this method offers for dioxin and environmental contaminant analysis.


Solutions


Waters LC-MS and GC-MS systems offer absolute performance in separation and sensitivity for dioxins and furans analysis.

Waters LC-MS and GC-MS systems offer absolute performance in separation and sensitivity for dioxins and furans analysis.

Absolute power to easily quantitate your most challenging compounds

Absolute power to easily quantitate your most challenging compounds

Achieve and maintain high performance and productivity with significantly increased sensitivity for negative ionizing compounds with the Xevo TQ Absolute, Waters compact, sustainable tandem quadrupole mass spectrometer.

  • Dioxins and Furans

Superior performance in your routine quantitative analyses

Superior performance in your routine quantitative analyses

Improve your laboratory productivity and capabilities with Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer that adds adaptability and flexibility to your analytical capabilities for easy detection.

  • Dioxins and Furans

Complete coverage for confident characterization

Complete coverage for confident characterization

Maximize sample information for your analytes from detailed characterization to accurate quantitation with the Xevo G3 QTof and ensure you can keep pace with the changing demands on your laboratory. 

  • Dioxins and Furans

No compromise atmospheric pressure ionization GC-MS

No compromise atmospheric pressure ionization GC-MS

Discover the benefits that Waters APGC Source offers to your laboratory in terms of operational efficiency, analytical quality, and cost savings to overcome the typical limitations of vacuum-based systems and improve confidence in analyte identification.

  • Dioxins and Furans

Performance that advances your lab

Performance that advances your lab

Improve laboratory productivity by enhancing the characterization of your complex samples using Waters ACQUITY UPLC H-Class PLUS System that offers improved resolution and advanced tools to simplify and streamline your method development workflow.

  • Dioxins and Furans


The data speaks for itself

The data speaks for itself
Evaluation of robustness of electrospray (blue) and UniSpray (orange) over 30 injections of a surface water sample. Evaluation of robustness of electrospray (blue) and UniSpray (orange) over 30 injections of a surface water sample.
Results from fly ash QC sample. Results from fly ash QC sample.
Residuals plot and linear regression of a five point calibration of 2378-TCDD ranging from 0.5 pg to 200 pg run on APGC-QTof. 5b. Standard reference sediment NIST1944 (ng/kg dry-mass) extracted by the modified QuEChERS method and analyzed by GC-HRMS and with APGC-QTof. Comparison run on a 40 m Rtx-Dioxin2 column with a flow rate of 1 mL/min. Residuals plot and linear regression of a five point calibration of 2378-TCDD ranging from 0.5 pg to 200 pg run on APGC-QTof. 5b. Standard reference sediment NIST1944 (ng/kg dry-mass) extracted by the modified QuEChERS method and analyzed by GC-HRMS and with APGC-QTof. Comparison run on a 40 m Rtx-Dioxin2 column with a flow rate of 1 mL/min.
Comparison of the unknown compound spectra from Population 1 to a standard of BTH at 1 ppm.   Comparison of the unknown compound spectra from Population 1 to a standard of BTH at 1 ppm.

Webinars and Resources



  • Brochure

Dioxins and Furans Analysis

Dioxins and Furans Analysis
  • Blog

USEPA Approves APGC Tandem Quadrupole Mass Spectrometry as Alternative Test Procedure for Dioxin Analysis

USEPA Approves APGC Tandem Quadrupole Mass Spectrometry as Alternative Test Procedure for Dioxin Analysis
  • Brochure

APGC: No Compromise Atmospheric Pressure Ionization GC-MS

APGC: No Compromise Atmospheric Pressure Ionization GC-MS
  • Case Study

Growing Demand for Rapid Food Contaminant Detection Spurs New Method Development at NofaLab

Growing Demand for Rapid Food Contaminant Detection Spurs New Method Development at NofaLab
  • Case Study

APGC Advances Ultra-Trace Toxins Analysis in Feed & Food

APGC Advances Ultra-Trace Toxins Analysis in Feed & Food
  • White Paper

APGC-MS/MS: A New Gold Standard for Dioxin and Furan Analysis

APGC-MS/MS: A New Gold Standard for Dioxin and Furan Analysis
  • On Demand Webinar

APGC Technology - What Makes it Suitable for Dioxins/POPs?

APGC Technology - What Makes it Suitable for Dioxins/POPs?

Related

Screen and quantify pollutants in drinking water, surface water, and soil with Waters robust, reliable, and sensitive lab equipment for environmental analysis.

Learn more about Dioxins and Furans Solutions.

Learn more about Dioxins and Furans Solutions.

Air pollution from factory