CORTECS Chemistry Offering

CORTECS Columns are available in both reversed-phase and HILIC options, giving you the flexibility and power to develop methods for challenging separations even faster. With different particle characteristics and innovative charged surface modifications, CORTECS Columns are suitable for use in a wide variety of applications.

Exceptional Peak Shape with C18+

CORTECS C₁₈+ is a general purpose, reversed-phase column which features a positively charged surface modification for exceptional peak shape of basic compounds when analyzed using acidic, low-ionic strength mobile phases such as formic acid.

Benefits of CORTECS C₁₈+  Columns:

• Unique column selectivity
• Exceptional peak shape and loading capacity
• No need for ion-pair reagents
• Improved signal-to-noise performance
• Chemically stable at low pH
• Fully LC-MS compatible

Increased Polar Analyte Retention with NEW CORTECS T3

CORTECS T3 Columns are the newest members of the CORTECS family. CORTECS T3 Columns provide balanced retention for both polar and non-polar compounds under reversed-phase conditions . The increased 120Å pore diameter enables the use of 100% aqueous mobile phase without the fear of phase dewetting and the low level C₁₈ ligand bonding and proprietary end-capping allows polar molecules to interact with residual hydrophilic silanols providing more retention.

Benefits of CORTECS T3 Columns:

• Compatible with 100% aqueous mobile phase conditions
• Increased retention for polar molecules under reverse-phase conditions when compared to other solid-core columns
• Chemically stable at low pH
• Fully LC-MS compatible

Maximize Efficiency & Throughput with C8

CORTECS C₈ Columns are another new addition to the CORTECS Column family.  CORTECS C₈ Columns have lower hydrophobicity when compared to typically bonded C₁₈ columns and are useful in the separation of strongly hydrophobic compounds. They are also ideal for chemists looking to transfer/ scale compendial C₈ HPLC methods to more robust column technology.

Benefits of CORTECS C₈ Columns:

• The capability to transfer compendial C₈ HPLC methods to more robust column technologies
• Less hydrophobic (retentive) than typical C₁₈ columns
• Chemically stable at low pH
• Fully LC-MS compatible

Maximize Efficiency & Selectivity with Phenyl

CORTECS Phenyl Columns are newly added to the CORTECS Column family. CORTECS Phenyl Columns are an excellent alternative to typically bonded C₁₈ phases, particularly for aromatic compounds, based on their unique selectivity provided by the Pi-Pi bond interactions with the benzyl ring.  The pi-pi bond interactions can be further enhanced using protic solvents such as methanol. 

Benefits of CORTECS Phenyl Columns: 

• Alternate selectivities for highly aromatic compounds when compared to a typical C₁₈ chemistry
• Chemically stable at low pH
• Fully LC-MS compatible

Expanded Selectivity with NEW Shield RP18

CORTECS Shield RP18 Columns are the newest members of the CORTECS family.  CORTECS Shield RP18 Columns incorporate an imbedded polar carbamate group into the bonded phase ligand that provides alternative selectivity for phenolic compounds as well as improved peak shape for basic analytes. The alternative selectivity, when compared to a typical C₁₈  boned phase, makes CORTECS Shield RP18 and excellent choice for methods development.

Benefits of CORTECS Shield RP18 Columns:

• Alternative selectivity when compared to typical C₁₈ bonded chemistries, especially for phenolic compounds
• Improved peak shape for basic analytes
• Compatible with 100% aqueous mobile phases
• Chemically stable at low pH

Faster Separations for Improved Throughput & Productivity

Improve your throughput with CORTECS Columns. CORTECS 2.7 µm Columns offer the unique advantage of operating at lower backpressure without an efficiency or resolution trade off. Achieve faster separations without sacrificing performance. When paired with an ultra- low dispersion system such as the ACQUITY UPLC I-Class System, CORTECS 1.6 µm Columns allow you to achieve previously unattainable levels of efficiency.

Setting the Standard for Reproducibility

Waters' cutting-edge manufacturing facilities are dedicated to producing columns that maximize laboratory performance. As a primary manufacturer of silica and hybrid particles we are able to continually monitor and control the manufacturing process over the lifetime of a product. Controlled manufacturing processes ensure you receive the best, most reliable column possible for consistent performance year after year. CORTECS Columns are created using state-of-the-art column packing techniques and bonding and end-capping processes that result in consistent, reproducible performance, and long column lifetimes.

Future Proof Your Laboratory

In the contemporary world of multi-national and multi-site laboratories whose LC technology may differ, Waters recognizes the need for versatility and ease of method transfer. CORTECS Columns offer particle sizes ideal for HPLC, UHPLC, and UPLC platforms, assuring a simple, seamless method transfer with consistent results across different particle sizes and column configurations.

VanGuard Column Protection

The often complex sample matrices encountered in pharmaceutical, natural product, environmental, and industrial chemical analysis prematurely shorten analytical column lifetime and degrade chromatographic performance. Waters VanGuard Pre-Columns and VanGuard Cartridge Columns help improve analytical column performance by removing particulate and chemical contamination that may be present in the mobile-phase stream—without compromising chromatographic performance. 

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Free OnDemand Webinar

Separation scientists continue to search for new ways to increase efficiency to achieve higher resolution separations and greater throughput in their chromatographic analyses. CORTECS® UPLC® Solid-Core Particle Columns were developed to deliver the ultimate in efficiency when paired with low dispersion UPLC instrumentation. For continued improvements in resolution and speed using HPLC and UHPLC systems, Waters proudly introduced CORTECS 2.7 μm Solid-Core Particle Columns earlier this year. As the newest member of the CORTECS Column family, CORTECS 2.7 μm Columns join CORTECS UPLC Columns, for seamless method transfer across instrument platforms.