Mass Spectrometry Direct Analysis

Mass Spectrometry Direct Analysis

Waters Direct Analysis technologies combine high performance mass spectrometry with innovative direct sampling tools, minimizing time on sample preparation and delivering clear, precise results.

Waters Direct Analysis technologies combine high performance mass spectrometry with innovative direct sampling tools, minimizing time on sample preparation and delivering clear, precise results.
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Waters technologies for direct-from-sample analysis provide you with the information you need to quickly and objectively interpret molecular profiles and make confident decisions based on definitive mass spectrometry data. Get the answers you need, when you need them, for a wide-range of applications and molecule types.

Atmospheric Solids Analysis Probe Upgrade
The Atmospheric Solids Analysis Probe is a useful tool for the rapid direct analysis of volatile and semi-volatile solid and liquid samples using atmospheric pressure ionization.

DESI XS
Obtain chemical information directly from a wide range of surfaces with Desorption Electrospray Ionization (DESI) mass spectrometry imaging with DESI XS.

High Definition Imaging (HDI) Software
Streamline the mass spectral imaging workflow with High Definition Imaging (HDI) Software, ideal for imaging experiments on SYNAPT systems and DESI imaging with a single user interface.

MALDI
For confident and clear molecular visualization, equip your lab with a Waters Matrix Assisted Laser Desorption Ionization (MALDI) solution.

LiveID Software
LiveID Software enables real-time sample classification using direct analysis mass spectrometry (MS), for informed, real-time decisions.

RADIAN ASAP Direct Mass Detector
Improve your drug discovery cycle, expand your client services, and achieve more with the RADIAN ASAP rapid direct analysis system.

REIMS Research System with iKnife
REIMS Research System with iKnife Sampling Device is a direct sampling ionization technique that combines with high performance time-of-flight MS for rapid molecular profiling.
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Mass Spectrometry (MS) Direct Analysis refers to techniques that allow the rapid examination of samples with minimal or no preparation, bypassing traditional steps like extraction, purification, or chromatography. These methods are designed to streamline workflows, providing fast and accurate results in applications such as clinical diagnostics, pharmaceutical research, environmental monitoring, and forensic science.

Traditional MS typically involves time-consuming preparation steps to isolate and purify analytes before analysis. In contrast, direct analysis minimizes or eliminates these processes, allowing raw samples to be analyzed more efficiently. Techniques like Desorption Electrospray Ionization (DESI), Direct Analysis in Real Time (DART), Laser Ablation Electrospray Ionization (LAESI), and Paper Spray Ionization are commonly used, each suited to different sample types, such as solids, liquids, or biological tissues. These methods enable ionization directly from the sample surface, often under ambient conditions, making them faster and more practical for high-throughput environments.

Direct MS analysis offers several key benefits: it saves time by reducing sample preparation, simplifies workflows, and lowers costs due to reduced consumable use. It also helps preserve sample integrity, as there is less manipulation involved, which is crucial for sensitive samples like forensic evidence or biological tissues. Applications include rapid drug detection in forensics, biomarker analysis in clinical diagnostics, and quality control in pharmaceuticals.

Overall, MS direct analysis enhances the speed, efficiency, and accuracy of mass spectrometry, making it ideal for industries where quick, reliable results are essential.