Food and Nutrition Research

Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs! Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs!

Good nutrition is fundamental for good health and the prevention, treatment and management of disease. The relationship between food, nutrition and health, however, is complex, dynamic, and multi-faceted and highly affected by biological as well as environmental, socioeconomic, cultural and behavioral factors. Research focuses on unraveling the link between dietary patterns, individual foods or food constituents and the physiological effects at cellular, tissue and whole-body level after acute and chronic uptake.

Waters Corporation provides enabling analytical technologies to identify and quantify minute amounts of individual compounds in highly complex matrices, food or biological fluids, and to monitor molecular changes in the body in a highly specific and sensitive manner.

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Foodomics

Foodomics is the study of food and nutrition through the application and integration of advanced omics technologies, including metabolomics, providing a comprehensive overview of the overall metabolites present in food or in biological fluids related to dietary intake. Non-targeted profiling, looking at differences, can provide insights about the molecular mechanism that can explain the bioactivity/safety/quality of food and food compounds and lead to the discovery of new biomarkers.

Analysis of Bioactive Compounds in Foods

Methods using HPLC or UPLC, coupled with optical detectors and/or mass spectrometers, are often used in food and nutrition research, for the detection and putative assignment of up to hundreds of metabolites in a single analysis. The integration of ion mobility spectrometry into the workflow, including the recent Cyclic IMS, is a powerful tool for the differentiation and improved identification of structurally similar metabolites.

Sample Preparation and Chromatography Solutions

Extraction methods for foodomics need to capture a broad range of metabolites from food or biofluids, while excluding components such as proteins, which might impact the analysis. The chemistry of compounds contributing to the understanding of the interaction between food and nutrition vary hugely, so Waters offers a range of chromatographic columns for separation of polar (e.g. BEH Amide or BEH Z-HILIC) and non-polar (e.g. CSH C8 or HSS T3) entities with high efficiency (UPLC).

Intuitive Informatic Workflows

Progenesis QI enables you to accurately quantify and identify compounds in your samples that are significantly changing. All ions relating to the same compound are deconvoluted to provide accurate quantification, after which it is possible to putatively identify compounds using relevant compound databases and evaluate statistically significant abundance changes across groups. The result is a list of compounds of interest for further investigation.