IonSABRE APCI Probe Accessory

IonSABRE APCI Probe Accessory

More effectively analyze high-polarity compounds

More effectively analyze high-polarity compounds

Atmospheric Pressure Chemical Ionization (APCI) is an effective method for analyzing lower-polarity compounds. The high-efficiency IonSABRE™APCI probe offers significant improvements in sensitivity compared with earlier versions of probe, particularly at higher liquid flow rates.

IonSABRE APCI Probe Accessory
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Overview

Ionization Process

With APCI, the sample stream is nebulised and analytes are desolvated using a combination of gas flow and high temperatures. The desolvated compounds are ionized by charge transfer as they pass through a plasma created by a corona discharge. Flow rates up to 2 mL/min are acceptable.

The IonSABRE APCI probe with thermally enhanced heater design provides improved heat distribution and sample vaporization. The support gas flow also maximizes transmission of sample droplets into the ion source.

Together, these features provide optimum APCI performance leading to superior limits of quantitation in compound quantification and identification studies.

Instrument Compatibility

The IonSABRE APCI probe is available for the following MS instruments:

  • ACQUITY™ SQD/TQD, 3100, SQ Detector 2, Xevo™ TQD
  • Xevo TQ MS, Xevo TQ-S, Xevo TQ-S micro
  • Xevo G2 QTof, Xevo G2-S QTof, Xevo G2-XS QTof
  • Xevo G2 Tof, Xevo G2-S Tof, Xevo G2-XS Tof
  • Xevo TQ-XS
  • MALDI SYNAPT MS, MALDI SYNAPT HDMS
  • SYNAPT G2 MS, SYNAPT G2 HDMS, MALDI SYNAPT G2 MS, MALDI SYNAPT G2 HDMS
  • (MALDI) SYNAPT G2-S MS, (MALDI) SYNAPT G2-S HDMS
  • (MALDI) SYNAPT G2-Si MS, (MALDI) SYNAPT G2-Si HDMS

*An additional conversion kit is included with the LCT Premier IonSABRE probe option to allow Ion Sabre APCI Exact Mass experiments.

Equipment and Installation

The accessory kit comprises:

  • IonSABRE probe and Corona pin
  • Spare parts kit and User operation guide
  • Free-standing power supply unit ( selected instrument only)

Although the accessory is easy to install, Waters strongly recommend installation and operation confirmation/training by a Field Service Engineer.

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The IonSABRE Atmospheric Pressure Chemical Ionization (APCI) Probe is a high-performance tool designed to improve the analysis of low-polarity compounds in mass spectrometry. It provides enhanced sensitivity and performance compared to earlier models, particularly at higher liquid flow rates, making it ideal for laboratories requiring accurate and efficient chemical analysis.

The probe"s key feature is its advanced heating system, which ensures even heat distribution for effective sample vaporization. This results in better ionization efficiency and improved detection limits, enabling precise quantitation even for trace compounds. Capable of handling liquid flow rates up to 2 mL per minute, the IonSABRE APCI probe is well-suited for high-throughput applications while maintaining excellent sensitivity and performance. Its robust design includes a thermally optimized heater and support gas flow system to ensure consistent and reliable operation.

The APCI process involves converting a liquid sample into a vapor and ionizing it using heat, gas flow, and a plasma generated by corona discharge. The IonSABRE probe optimizes this process, increasing ionization efficiency and delivering more accurate results.

The probe is compatible with various Waters mass spectrometry instruments, including the ACQUITY™, Xevo™, and MALDI SYNAPT™ series. An optional conversion kit expands its capabilities, enabling exact mass measurements for specific applications. Its broad compatibility allows laboratories to integrate the probe seamlessly into their existing systems, enhancing workflows without requiring significant modifications.

To support users, Waters offers detailed manuals, maintenance guides, and instructional videos covering operation and routine upkeep. These resources simplify tasks like replacing the sample capillary, helping users maximize the probe"s performance while minimizing downtime.

To conclude, the IonSABRE APCI probe is a versatile and efficient accessory for mass spectrometry, designed to improve sensitivity and performance when analyzing low-polarity compounds. Its advanced features, broad instrument compatibility, and strong user support make it an essential tool for laboratories seeking reliable and precise analytical solutions.