Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs! Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs!

Synthetic Oligonucleotide Analysis

Robust, compliant-ready solutions for characterization and monitoring of oligonucleotides

The landscape for oligonucleotides is diverse. As the pipeline for oligonucleotide therapeutics such as antisense, siRNA, and gRNA continues to expand, it grows along with increasing demand for primers and probes for clinical diagnostics.

Modifications, conjugation, and novel formulations are increasing the complexity of oligonucleotide therapeutics, necessitating analytical tools that deliver high-quality results, improve efficiency, and enable regulatory compliance. Waters brings industry-leading expertise, providing analytical solutions to support the development and commercialization of these exciting new molecules. With Waters, your lab can:

Characterize and monitor product identity (ID) and impurities with dedicated and optimized workflows
Confirm oligonucleotide sequence with mass spectrometry and localize any modified nucleotides
Deploy compliance-ready solutions to meet corporate data integrity & regulatory requirements for data acquisition, processing, and reporting.

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Overview

Literature

Application Notes

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Enhanced Recovery, Repeatability, and Productivity

For quantitative analyses, effective sample preparation is the foundation for achieving maximum recovery, consistency, and lower limits of detection. Waters offers a market-leading range of sample preparation tools from robotic automation to vials and solid-phase extraction (SPE), enabling you to work more efficiently with greater productivity and fewer errors.

Unparalleled Oligonucleotide Separation Performance

Oligonucleotides are prone to metal interactions that can negatively impact chromatographic peak shape, recovery, and detection performance. Labs routinely run conditioning and passivation procedures to mitigate these interactions, but these reduce equipment utilization and significantly impact lab productivity. Waters ACQUITY Premier Columns and Systems significantly reduce the impact of non-specific adsorption on oligonucleotide separations, improving sensitivity and repeatability and giving you supreme confidence in your data and maximum throughput for your analyses.

Product image of the ACQUITY Premier Solution

Product image of the BioAccord LC-MS System

Fit-for-purpose, Efficient LC-MS Workflows

From characterization to production monitoring, drug metabolism and pharmacokinetics (DMPK) studies, quality control (QC) release and more, Waters offers a range of optimized LC-MS workflows – many designed for non-expert users – that deliver clear results, maximum robustness, sensitivity, and repeatability.

Characterization workflows enable users to confidently define product quality attributes and impurities, while monitoring workflows save significant time in data acquisition, processing, and solution deployment with targeted analysis of these attributes while maintaining sensitive detection of unexpected species.

Automation and compliance-ready tools accelerate data analysis and reporting, and facilitate the sharing of information across systems, labs, and geographies – for enhanced productivity and reduced regulatory risk.