Ostro Pass-Through Sample Preparation Products

Ostro Pass-Through Sample Preparation Products

A simpler way to cleaner samples

A simpler way to cleaner samples

Sample preparation does not need to be time-consuming or complicated with Ostro Pass-Through Sample Preparation Products, which provide a simple solution for phospholipid and protein removal. Requiring minimal to no method development, this technology is quick to implement into your laboratory’s workflow.

The Ostro protein precipitation and phospholipid removal plate produces cleaner sample extracts resulting in more sensitive analyses, higher sample throughput, reduced instrument downtime, and increased laboratory productivity.

Ostro protein precipitation and phospholipid removal 96-well plate for pass-through sample preparation Ostro Pass-Through Sample Preparation Products

Specifications

Overview

  • Removes proteins, particulates, and more than 95% of phospholipids
  • Improves reproducibility for more consistent, robust methods
  • Increases throughput with an easy-to-implement protocol
  • Works great for biological samples (such as plasma, serum, and whole blood)
  • 96-well plate format enables high throughput and is compatible with automation

Recommended Use: For the removal of phospholipids and proteins.



Ostro Pass-Through Sample Preparation Benefits

Ostro Pass-Through Sample Preparation Benefits

Ostro

PPT

LLE

SSLE

SPE

Requires method development

Requires method development

Requires method development

Requires method development

Requires method development

Requires method development

Requires method development

Highest analyte selectivity

Highest analyte selectivity

Highest analyte selectivity

Highest analyte selectivity

Highest analyte selectivity

Highest analyte selectivity

Highest analyte selectivity

Direct injection of eluates

Direct injection of eluates

Direct injection of eluates

Direct injection of eluates

Direct injection of eluates

Direct injection of eluates

Direct injection of eluates

Simple

Simple

Simple

Simple

Simple

Simple

Simple

High throughput

High throughput

High throughput

High throughput

High throughput

High throughput

High throughput

Phospholipid removal

Phospholipid removal

Phospholipid removal

Phospholipid removal

Phospholipid removal

Phospholipid removal

Phospholipid removal

Highest sensitivity

Highest sensitivity

Highest sensitivity

Highest sensitivity

Highest sensitivity

Highest sensitivity

Highest sensitivity

Clean extracts

Clean extracts

Clean extracts

Clean extracts

Clean extracts

Clean extracts

Clean extracts

Fast

Fast

Fast

Fast

Fast

Fast

Fast

Environmentally friendly

Environmentally friendly

Environmentally friendly

Environmentally friendly

Environmentally friendly

Environmentally friendly

Environmentally friendly


Simpler way to implement protein and phospholipid cleanup

Implement protein and phospholipid cleanup easily while delivering high recoveries with the universal single-solvent sample preparation method used in the Ostro Pass-through Sample Preparation Plate. Proven to work with a wide range of acidic, basic, and neutral compounds, this technology provides superior results with improved reproducibility for more consistent, robust methods. Unlike the Protein Precipitation (PPT) method, Ostro Pass-through Sample Preparation Plates remove phospholipids that can build up on the analytical column and foul the mass spectrometry source. Ostro also requires less sample preparation time to obtain optimal recoveries for diverse analyte sets than liquid-liquid extraction (LLE) or solid-supported liquid extraction (SSLE). 


Faster sample processing and throughput

Streamline sample processing and optimize sample throughput with Ostro Pass-through Sample Preparation Plates, which require no method development, significantly reduce sample preparation time, are easy to automate, and provide results faster. Ostro’s direct inject capability provides further time savings by eliminating dry-down and reconstitution steps. In contrast to PPT, the Ostro Plate has been shown to effectively remove signal-interfering phospholipids. This provides particular benefits when steep, fast, ballistic gradients are used to analyze large numbers of samples in a short time period. By removing phospholipids, Ostro Sample Preparation Plates prevent them from building up over multiple injections, thus increasing system uptime and overall productivity.


More complete phospholipid cleanup

As a major source of matrix effects, phospholipids contribute to assay variability, decreased sensitivity, and unpredictable mass spectrometry results. Unfortunately, many commonly used sample preparation techniques like PPT and LLE do not remove phospholipids. The Ostro Plate provides the best solution to this dilemma by offering more complete phospholipid cleanup than any other competitive technique and removing variability, even across multiple lots of human plasma – for consistent, comprehensive, superior results.



Resources

Documents

Documents


Support

Support


Related

Meet your sample preparation needs, from simple matrix clean-up to more complex sample preparation challenges, with Oasis SPE products. Research our Oasis Solid-Phase Extraction plates and cartridges.

Reduce sample losses due to non-specific binding (NSB) and ionic interactions with QuanRecovery Vials and Plates with MaxPeak High Performance Surfaces.

Offers and Discounts

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Ostro Pass-Through Sample Preparation Products for Protein Precipitation

Every second you spend in the lab is crucial, so don’t you want a protein precipitation and phospholipid removal workflow that saves you time? You’ll find that and so much more with Ostro Pass-Through Sample Preparation Products. This simple sample preparation solution for phospholipid and protein removal from complex sample matrices, resulting in quick, easy and more sensitive analyses, higher sample throughput and reduced LC-MS instrument downtime. This all adds up to a happier, healthier, more productive and profitable lab environment for all.

Ready to increase laboratory productivity with the help of Ostro Pass-Through Sample Preparation Products? Turn to the Ostro Protein Precipitation & Phospholipid Removal Plate, designed specifically for protein and particulate removal from sample matrices. This plate can remove more than 95% of phospholipids from your samples, proving that your sample preparation protocol can be improved with your current equipment. Plus, if you’re wondering if this product works with biological sample matrices, know that it does work great for plasma, serum and whole blood. What’s more, the 96-well plate format adapts to automation platforms to increase productivity.

Are you simply looking for more ways to streamline sample processing? You can do so with Ostro Pass-Through Sample Preparation Plates, as they require no method development, significantly reduce sample preparation time and are much easier to apply to any lab automation system. Plus, with Ostro’s direct inject capability, you can eliminate time usually spent during dry-down and reconstitution steps. This process helps even more to remove and reduce signal-interfering phospholipids. That means you can analyze multiple samples with steep, fast and ballistic gradients. This kind of streamlined workflow leads to increased system uptime and overall productivity.

Many common sample preparation techniques, including Protein Precipitation (PPT) and liquid-liquid extraction (LLE), do not remove phospholipids. That’s why when you need phospholipid removal from your complex sample matrices, you should trust the Ostro Plate, as it provides the best solution to phospholipid cleanup. For consistent, comprehensive and superior results in sample preparation for protein- and phospholipid-containing samples, equip your lab with the Ostro Protein Precipitation and Phospholipid Removal Plates.

At Waters, we care deeply about simplifying sample preparation across the globe and in labs everywhere. It doesn’t matter if you have an IVD testing laboratory or a more traditional analytical lab environment, as we have sample preparation products that are built specifically for your applications. Plus, our sample prep solutions maximize sensitivity and increase throughput, all leading to the development of more robust methods. You need only look at our sample preparation application kits to see just how much these products can assist your workflow. Shop Waters Sample Preparation Products to learn more.