ProteinWorks Kits

ProteinWorks Kits

Take the complexity out of protein quantification

Take the complexity out of protein quantification

Sample preparation is a major source of variability in traditionally complex LC-MS/MS protein quantification workflows via the surrogate peptide approach. ProteinWorks eXpress Digest Kits simplify and accelerate protein digestion, streamlining and standardizing complex pre-analytic bioanalysis/DMPK workflows for LC-MS protein quantification in whole or immunopurified plasma. 

With ProteinWorks, your lab can routinely achieve highly reproducible, accurate, and sensitive protein quantification methods. This flexible and automatable kit-based approach reduces method development time and is easily deployable from lab-to-lab and site-to-site.

ProteinWorks Sample Preparation Kits allow discovery and early development laboratories to achieve standardized, reproducible, and sensitive protein quantification via the surrogate peptide approach. ProteinWorks Kits
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Specifications

Overview

  • Simplifies sample preparation for protein bioanalysis/DMPK with pre-measured, lot-traceable reagents, enabling seamless method transfer across different labs and different analysts
  • Enables fast, reproducible, and sensitive results for small proteins, mAbs, and ADCs
  • Reduces time to result and cost of analysis with a simple, easy-to-implement, optimized protocol that minimizes or eliminates method development
  • Automatable on the Hamilton STARWorks platform to maximize productivity

Recommended Use: For accurate and precise quantification of various proteins.

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Experience a streamlined, reproducible approach

Protein quantification workflows are prone to high variability due to their complex, multi-segment nature. Your assays must achieve acceptable accuracy, precision, and reproducible results to make critical research decisions. ProteinWorks eXpress Digest Kits can achieve single digit intra-kit and inter-kit reproducibility across several monoclonal antibodies.

Simplify and standardize sample preparation

Bioanalysts face many decisions when developing and deploying LC-MS protein quantification workflows. Along with multiple options, sample preparation is a major source of variability. A lack of standardization and inherent variability makes reproducible method transfer between analysts and labs challenging. ProteinWorks kits facilitate laboratory and data consistency with a standardized, kit-based approach that is easily deployable from analyst to analyst, lab to lab, and sponsor to CRO.

Achieve your desired level of sensitivity

Achieving desired detection limits can be challenging. Decisions regarding the choice of reagents, their concentrations, as well as time, temperature, and the number of steps can all affect method sensitivity. ProteinWorks offers a universal, kit-based sample preparation method with pre-weighed, lot-traceable reagents, and simple, stepwise instructions, allowing rapid quantification of infliximab down to 10 ng/mL.

Deliver optimal results with flexibility and automation

Achieving sensitivity, reproducibility, standardization, and accuracy with enough flexibility to accommodate different LC-MS protein quantification workflows can be challenging. Without the constraints of competitive kit-based approaches, ProteinWorks is optimized for a variety of different workflows, including protein bioanalysis/DMPK, allowing enough flexibility to deliver optimal results for your assays.

ProteinWorks is also automatable on the Hamilton STARWorks platform. An automated and generic kitted approach that includes a protocol and the necessary reagents can streamline method development and minimize the sample preparation complexity. The implementation of an automated liquid handler can maximize productivity, reduce human error, and improve analytical method performance.

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Related

Peptide Reversed-Phase Columns
Reversed-phase chromatography using ion-pairing reagents such as TFA and formic acid can deliver highly resolved separations of complex peptide mixtures whose sequences may differ by a single amino acid.

Intact mAb Mass Check Standard
Before performing mAb characterization or intact mass analysis of antibodies, benchmark your LC-MS system with the Waters Intact mAb Mass Check Standard.

Automation Workflow Kits and Scripts
Realize the full potential of your automation workstations with Waters sample preparation kits, and seamlessly automate your Waters workflow to gain laboratory efficiency.

Offers and Discounts

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ProteinWorks Kits are advanced solutions designed to make protein analysis easier and more effective. These kits include top-quality reagents and all the necessary components to ensure reliable and accurate results. Each reagent is carefully tested to guarantee purity and performance, providing consistency across different experiments. This consistency is crucial for achieving dependable results every time.

The kits also come with everything needed for various protein analysis tasks, such as sample preparation, digestion, and quantification. The components are designed to work together seamlessly, reducing variability and improving efficiency. Additionally, detailed protocols and guidelines are included, which are straightforward and easy to follow, making the kits accessible to both new and experienced researchers.

One of the great advantages of ProteinWorks Kits is their versatility. They can be used for a wide range of applications, including proteomics research, biomarker discovery, and clinical diagnostics. They are adaptable to different sample types and analytical methods, providing the flexibility needed for diverse research projects.

Using ProteinWorks Kits offers several benefits. They streamline the protein analysis process, saving time and effort by providing all necessary components in one package. The optimized protocols help researchers focus more on data analysis and interpretation. The high-quality reagents and standardized components ensure consistent and reliable results, which is essential for validating research findings.

Moreover, the precision of the components and the thorough testing of reagents lead to improved accuracy in protein quantification and analysis. This accuracy is vital for drawing meaningful scientific conclusions. The kits are also cost-effective, as they reduce the need for additional reagents and minimize experimental errors, leading to overall savings for laboratories. The all-in-one design of the kits simplifies purchasing and inventory management.

To conclude, ProteinWorks Kits are a comprehensive, efficient, and reliable solution for protein analysis. With their high-quality reagents, easy-to-follow protocols, and versatile components, these kits help researchers achieve the best possible results in their protein analysis projects. Whether for proteomics research, biomarker discovery, or clinical diagnostics, ProteinWorks Kits provide the essential tools needed to advance scientific research and innovation.