At-line information retrieval for new process development models

Overcome the limitations of sequential culture run and testing with the ability to access direct measurement of cell media and Product Quality Attributes (PQAs) during bioprocess development to allow near real-time decisions.

With at-line analysis and seamless data integration to the Ambr® 250 High Throughput System, your process engineers get the instant feedback they need for faster decisions and better understanding, enabling the build of more robust processes and de-risking batch failure.

With BioAccord LC-MS System and Ambr® 250 High Throughput System, your lab can:

• Collect more analytical data for robust statistical analysis
• Accelerate turnaround times
• Provide instant feedback on quality

More comprehensive cell culture media analysis

Together, the BioAccord LC-MS System and Ambr® 250 High Throughput System provide a fast and complete method for screening of feed and spent media samples. With these systems, your lab can achieve cell culture media analysis that is:

• Efficient: No additional sample preparation needed
• Specific: Track over 200 compounds with high accuracy
• Information-rich: Automated structural elucidation of unknown components
• Reproducible and sensitive: Down to sub ng/mL

Automated product quality attribute monitoring

The BioAccord LC-MS System and Ambr® 250 High Throughput System provide a fast, end-to-end, and automated solution for product quality attribute analysis. Together, this powerful pairing provides:

• Multi-attribute tracking: Monitor titer, identity, purity, glycan profile, modifications
• Efficiency: 6-minute run time with automated processing and interpretation
• Accessibility: Automate workflows with a system that is easy to deploy and to operate
• Connectivity: Results feed directly into Sartorius Ambr® 250 for easy set up and fast decision-making
• Understanding: Link process inputs to quality outputs with data generated on a single platform

On Demand Webinar: Performing Product Quality Measurements in your Bioprocessing Lab - It's Easier Than You Think

The Waters BioAccord™ LC-MS System enables direct measurement of multiple critical process and product attributes including identity, purity, and glycosylation. In this webinar, we will show you how to add intact glycoprofiling and subunit drug product quality measurements along with spent media profiling to your routine monitoring workflows for process development. In addition to reducing turnaround time from sampling to results, we will highlight how to minimize the burden of sample preparation through automation. 

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